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An integrated POC solution for non-invasive diagnosis and therapy monitoring of Heart Failure patients

Objective

The aim of the KardiaTool project is to translate a laboratory proven concept of a saliva biosensor to the clinical practice for addressing the priority needs in personalized HF diagnostics and therapy monitoring at the point of care. The KardiaTool platform includes: (i) An easy to use portable POC device (KardiaPOC) with a disposable Lab-on-a-Chip (LOC), for the non-invasive, rapid and accurate qualitative and quantitative assessment of HF biomarkers, from saliva samples. KardiaPOC device will integrate a variety of sensors, actuators, Microelectromechanical systems (MEMS), micro-electronics, bio-chemicals and functionalized magnetic nanoparticles (MNPs), onto a disposable, low cost LOC. (ii) A decision support software (KardiaSoft) based on predictive modelling techniques, that analyzes the POC data and other patient’s data, directly added by the healthcare professionals, and delivers information related to HF diagnosis and therapy monitoring. The innovation lays in the incorporation of four novel saliva biomarkers that have been proven in a laboratory setting and bring a new promising concept for addressing the priority needs of the clinical arena. KardiaPOC will provide the capability of simultaneously extracting key information from the saliva biomarkers: (i) NT-proBNP, (ii) TNF-a, (iii) Interleukin- 10, (iv) Cortisol. It is expected that identifying a comparable source to blood, for biomarker information, such as saliva, that is cost effective, less invasive, more convenient and acceptable for both patients and healthcare professionals would be beneficial for the healthcare community. The challenge of KardiaTool is: (i) to translate a laboratory proven concept of a saliva biosensor into an MNBS platform, for HF diagnostics and therapy monitoring, at the point of care, following GLP (ii) to validate the MNBS platform through pre-clinical and clinical testing following GCP and (iii) to industrialize the outcomes following GMP towards progress to marketization

Call for proposal

H2020-NMBP-X-KET-2017
See other projects for this call

Coordinator

UNIVERSITE LYON 1 CLAUDE BERNARD
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 446 132,43

Participants (14)

IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece
EU contribution
€ 588 750
Address
N Plastira Str 100
70013 Irakleio
Activity type
Research Organisations
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 467 612,50
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
UNIVERSITA DI PISA
Italy
EU contribution
€ 191 250
Address
Lungarno Pacinotti 43/44
56126 Pisa
Activity type
Higher or Secondary Education Establishments
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 399 375
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
BIOTRAY
France
EU contribution
€ 218 750
Address
82 Rue Cyprian
69100 Villeurbanne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MICRONIT HOLDING BV
Netherlands
EU contribution
€ 424 633,75
Address
Colosseum 15
7521 PV Enschede
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM
Belgium
EU contribution
€ 470 325
Address
Kapeldreef 75
3001 Leuven
Activity type
Research Organisations
PANEPISTIMIO IOANNINON
Greece
EU contribution
€ 160 000
Address
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina
Activity type
Higher or Secondary Education Establishments
VALOTEC
France
EU contribution
€ 401 562,50
Address
1 Mail Du Professeur Georges Mathe
94800 Villejuif
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 155 995,94
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
ENACHIP INC
United States
EU contribution
€ 392 500
Address
1 Righter Parkway Suite 260
19803 Wilmington
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY OF SURREY
United Kingdom
EU contribution
€ 294 871,25
Address
Stag Hill
GU2 7XH Guildford
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 168 802,50
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments
ECOLE NORMALE SUPERIEURE DE LYON

Participation ended

France
EU contribution
€ 219 319,68
Address
Parvis Rene Descartes 15
69342 Lyon
Activity type
Higher or Secondary Education Establishments