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An integrated POC solution for non-invasive diagnosis and therapy monitoring of Heart Failure patients

Objective

The aim of the KardiaTool project is to translate a laboratory proven concept of a saliva biosensor to the clinical practice for addressing the priority needs in personalized HF diagnostics and therapy monitoring at the point of care. The KardiaTool platform includes: (i) An easy to use portable POC device (KardiaPOC) with a disposable Lab-on-a-Chip (LOC), for the non-invasive, rapid and accurate qualitative and quantitative assessment of HF biomarkers, from saliva samples. KardiaPOC device will integrate a variety of sensors, actuators, Microelectromechanical systems (MEMS), micro-electronics, bio-chemicals and functionalized magnetic nanoparticles (MNPs), onto a disposable, low cost LOC. (ii) A decision support software (KardiaSoft) based on predictive modelling techniques, that analyzes the POC data and other patient’s data, directly added by the healthcare professionals, and delivers information related to HF diagnosis and therapy monitoring. The innovation lays in the incorporation of four novel saliva biomarkers that have been proven in a laboratory setting and bring a new promising concept for addressing the priority needs of the clinical arena. KardiaPOC will provide the capability of simultaneously extracting key information from the saliva biomarkers: (i) NT-proBNP, (ii) TNF-a, (iii) Interleukin- 10, (iv) Cortisol. It is expected that identifying a comparable source to blood, for biomarker information, such as saliva, that is cost effective, less invasive, more convenient and acceptable for both patients and healthcare professionals would be beneficial for the healthcare community. The challenge of KardiaTool is: (i) to translate a laboratory proven concept of a saliva biosensor into an MNBS platform, for HF diagnostics and therapy monitoring, at the point of care, following GLP (ii) to validate the MNBS platform through pre-clinical and clinical testing following GCP and (iii) to industrialize the outcomes following GMP towards progress to marketization
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Coordinator

UNIVERSITE LYON 1 CLAUDE BERNARD

Address

Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 446 132,43

Participants (14)

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IDRYMA TECHNOLOGIAS KAI EREVNAS

Greece

EU Contribution

€ 588 750

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 467 612,50

UNIVERSITA DI PISA

Italy

EU Contribution

€ 191 250

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany

EU Contribution

€ 399 375

BIOTRAY

France

EU Contribution

€ 218 750

MICRONIT MICROTECHNOLOGIES BV

Netherlands

EU Contribution

€ 424 633,75

INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM

Belgium

EU Contribution

€ 470 325

PANEPISTIMIO IOANNINON

Greece

EU Contribution

€ 160 000

VALOTEC

France

EU Contribution

€ 401 562,50

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 155 995,94

ENACHIP INC

United States

EU Contribution

€ 392 500

UNIVERSITY OF SURREY

United Kingdom

EU Contribution

€ 294 871,25

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

EU Contribution

€ 168 802,50

ECOLE NORMALE SUPERIEURE DE LYON

France

EU Contribution

€ 219 319,68

Project information

Grant agreement ID: 768686

Status

Ongoing project

  • Start date

    1 November 2017

  • End date

    30 April 2021

Funded under:

H2020-EU.2.1.1.1.

H2020-EU.2.1.2.

  • Overall budget:

    € 4 999 880,55

  • EU contribution

    € 4 999 880,55

Coordinated by:

UNIVERSITE LYON 1 CLAUDE BERNARD

France