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Interdisciplinary training network on the purinergic P2X7 receptor to control neuroinflammation and hyperexcitability in brain diseases.

Objective

Brain disorders affect ~179 million people and their families in Europe alone, with an annual cost to the taxpayer estimated at €800 billion- a greater economic burden than cardiovascular disease and cancer combined. Despite diverse etiology, overlap in clinical symptoms and comorbidities between brain disorders suggests shared patho-mechanisms. In particular, hyperexcitible states driven by glial activation and neuroinflammation appear near ubiquitous. Targeting these mechanisms offers the potential to ameliorate symptoms and reverse disease progression across a broad span of brain disorders. Functioning as a gatekeeper to neuroinflammation and mechanistic link between neuronal hyperexcitability and glial activation, the ATP-gated, ionotropic purinergic P2X7 receptor (P2X7R) offers the most promising target for pharmacological intervention in the neuroinflammation-hyperexcitability pathway, to date. With breakthroughs in understanding P2X7R function, highly promising effects demonstrated for antagonists in models of brain disease and vast investment in P2X7R-related drug development programmes, now is the perfect time to pool resources. PurinesDX brings together global leaders in translational research in purinergic signalling, Europe’s leading clinical specialists in a broad range of brain diseases, and industrial partners specializing in drug and biomarker development. Sharing unique genetic tools, newly developed diagnostic devices and novel, selective and brain-stable P2X7R antagonists, the synergism facilitated within PurinesDX will extend to the training of an urgently needed new generation of highly skilled, innovative, creative and entrepreneurial scientists. Alongside the provision of this interdisciplinary, international and intersectoral environment, an original and high level training in state-of-the-art neuroscience will be provided, nurturing a cohort of highly competitive researchers with potential to drive a new era of neuroscience research.

Field of science

  • /medical and health sciences/basic medicine/neurology/amyotrophic lateral sclerosis
  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases
  • /medical and health sciences/basic medicine/neurology/epilepsy
  • /natural sciences/biological sciences/neurobiology

Call for proposal

H2020-MSCA-ITN-2017
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

ROYAL COLLEGE OF SURGEONS IN IRELAND
Address
Saint Stephen's Green 123
2 Dublin
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 531 349,20

Participants (8)

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 249 216,48
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
EU contribution
€ 495 745,92
Address
Avenida De Seneca 2
28040 Madrid
Activity type
Higher or Secondary Education Establishments
KIRSERLETI ORVOSTUDOMANYI KUTATOINTEZET
Hungary
EU contribution
€ 447 827,04
Address
Szigony Utca 43
1083 Budapest
Activity type
Research Organisations
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 249 216,48
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
CENTRO DE INVESTIGACION BIOMEDICA EN RED ENFERMEDADES NEURODEGENERATIVAS
Spain
EU contribution
€ 247 872,96
Address
"Hospital Universitario ""Virgen Del Rocio"" - Edif. De Laboratorios, 2A Planta - Avda. Manual Siurot S/n"
41013 Sevilla
Activity type
Research Organisations
SARISSA BIOMEDICAL LIMITED
United Kingdom
EU contribution
€ 546 575,76
Address
Argent House 5 Goldington Road
MK40 3JY Bedford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOTALENTUM TUDASFEJLESZTO KFT
Hungary
EU contribution
€ 223 913,52
Address
Aulich Lajos Utca 26
2100 Goedoello
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACION TEOFILO HERNANDO
Spain
EU contribution
€ 495 745,92
Address
Calle Faraday 7
28049 Madrid
Activity type
Research Organisations

Partners (12)

JANSSEN PHARMACEUTICA NV
Belgium
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Affectis Phamaceuticals AG
Germany
Address

Dortmund
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Dr. Seibt Genomics GmbH
Germany
Address
Joseph-schumpeter-allee 15
53227 Bonn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Longboat Clinical Ltd
Ireland
Address
Unit 9, 4075 Kingswood Avenue, Citywest Business Park
D24 X095 Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACION CENTRO DE INVESTIGACION DE ENFERMEDADES NEUROLOGICAS
Spain
Address
Calle Sinesio Delgado 6
28029 Madrid
Activity type
Research Organisations
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO RAMON Y CAJAL
Spain
Address
Ctra Colmenar Vlejo Km 9.100
28034 Madrid
Activity type
Other
SEMMELWEIS EGYETEM
Hungary
Address
Ulloi Utca 26
1085 Budapest
Activity type
Higher or Secondary Education Establishments
Epilepsiezentrum Frankfurt Rhein-Main
Germany
Address

Frankfurt Rhein-main
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Klinik Max Planck Institut für Psychiatrie
Germany
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE UNIVERSITY OF WARWICK
United Kingdom
Address
Kirby Corner Road - University House
CV4 8UW Coventry
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD AUTONOMA DE MADRID
Spain
Address
Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid
Activity type
Higher or Secondary Education Establishments
SZENT ISTVAN UNIVERSITY
Hungary
Address
Pater Karoly Utca 1
2100 Godollo
Activity type
Higher or Secondary Education Establishments