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in vivo optogeneticS, elecTrophysiology and phArmacology with an ultRasonically-powered DUST for Parkinson's Disease

Objective

The main goal of the STARDUST project is to realize a novel wireless implantable and independent micro-scale device (200x200x200 µm3) enabling in-vivo electrophysiology, optogenetics and ultra-localized drug delivery in freely moving animals. The device will be used to target specific neural circuits of the brain and test a new therapeutic approach for Parkinson’s Disease (PD).
The methods used in this project are based on cutting-edge miniaturized technology combining integrated chips, microelectromechanical systems (MEMS), local drug delivery, integrated electrodes and micro-scale light emitting diodes (µLEDs). STARDUST will benefit from these advances and for the first time provide an implantable ultrasonically-powered miniaturized device for in-vivo optogenetics, local drug delivery and electrophysiological monitoring – all in one single device. The proposed device is expected to provide an output power of 1-20 mW/mm2 for optogenetics with two different wavelengths, one for neuron activation and one for triggering drug-delivery; STARDUST will provide proof of concept.
The main novelty of the STARDUST project is the convergence of multiple, interdisciplinary fields including optogenetics, triggered drug-delivery, miniaturized ultrasonic energy harvesting, material science and nanoelectronics. The main ambition of the project is to develop a new technology platform to be used for future implantable in-vivo optogenetic devices for monitoring and treating diseases, with an optional local drug delivery add-on beyond 2025. Establishing proof of concept of the STARDUST platform will be the foundation for other applications within photodynamic therapy such as cancer treatment and other neurological and non-neurological disorders.

Field of science

  • /medical and health sciences/basic medicine/neurology/parkinson
  • /medical and health sciences/medical biotechnology/implants

Call for proposal

H2020-FETOPEN-1-2016-2017
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

AARHUS UNIVERSITET
Address
Nordre Ringgade 1
8000 Aarhus C
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 967 948,75

Participants (8)

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 375 121,25
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 592 855
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
VIB VZW
Belgium
EU contribution
€ 417 635
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland
EU contribution
€ 360 513,75
Address
Western Road
T12 YN60 Cork
Activity type
Higher or Secondary Education Establishments
BIOMODICS APS
Denmark
EU contribution
€ 485 736,25
Address
Stengards Alle 31 A
2800 Kgs Lyngby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HUMBOLDT-UNIVERSITAET ZU BERLIN
Germany
EU contribution
€ 356 000
Address
Unter Den Linden 6
10117 Berlin
Activity type
Higher or Secondary Education Establishments
SPINVERSE OY
Finland
EU contribution
€ 171 622,50
Address
Tekniikantie 14
02150 Espoo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Universidade Federal do Pará
Brazil
EU contribution
€ 60 500
Address
Rua Augusto Corrêa 01
66075-110 Belém
Activity type
Higher or Secondary Education Establishments