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in vivo optogeneticS, elecTrophysiology and phArmacology with an ultRasonically-powered DUST for Parkinson's Disease

in vivo optogeneticS, elecTrophysiology and phArmacology with an ultRasonically-powered DUST for Parkinson's Disease

Objective

The main goal of the STARDUST project is to realize a novel wireless implantable and independent micro-scale device (200x200x200 µm3) enabling in-vivo electrophysiology, optogenetics and ultra-localized drug delivery in freely moving animals. The device will be used to target specific neural circuits of the brain and test a new therapeutic approach for Parkinson’s Disease (PD).
The methods used in this project are based on cutting-edge miniaturized technology combining integrated chips, microelectromechanical systems (MEMS), local drug delivery, integrated electrodes and micro-scale light emitting diodes (µLEDs). STARDUST will benefit from these advances and for the first time provide an implantable ultrasonically-powered miniaturized device for in-vivo optogenetics, local drug delivery and electrophysiological monitoring – all in one single device. The proposed device is expected to provide an output power of 1-20 mW/mm2 for optogenetics with two different wavelengths, one for neuron activation and one for triggering drug-delivery; STARDUST will provide proof of concept.
The main novelty of the STARDUST project is the convergence of multiple, interdisciplinary fields including optogenetics, triggered drug-delivery, miniaturized ultrasonic energy harvesting, material science and nanoelectronics. The main ambition of the project is to develop a new technology platform to be used for future implantable in-vivo optogenetic devices for monitoring and treating diseases, with an optional local drug delivery add-on beyond 2025. Establishing proof of concept of the STARDUST platform will be the foundation for other applications within photodynamic therapy such as cancer treatment and other neurological and non-neurological disorders.
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Coordinator

AARHUS UNIVERSITET

Address

Nordre Ringgade 1
8000 Aarhus C

Denmark

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 967 948,75

Participants (8)

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FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany

EU Contribution

€ 449 546,25

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 518 430

VIB

Belgium

EU Contribution

€ 417 635

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK

Ireland

EU Contribution

€ 360 513,75

BIOMODICS APS

Denmark

EU Contribution

€ 485 736,25

HUMBOLDT-UNIVERSITAET ZU BERLIN

Germany

EU Contribution

€ 356 000

SPINVERSE OY

Finland

EU Contribution

€ 171 622,50

Universidade Federal do Pará

Brazil

EU Contribution

€ 60 500

Project information

Grant agreement ID: 767092

Status

Ongoing project

  • Start date

    1 October 2017

  • End date

    30 September 2021

Funded under:

H2020-EU.1.2.1.

  • Overall budget:

    € 3 803 057,50

  • EU contribution

    € 3 787 932,50

Coordinated by:

AARHUS UNIVERSITET

Denmark