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DNA as a training platform for photodynamic processes in soft materials

Objective

Light interaction with biomaterials is the driving mechanism of fundamental biological processes, from photosynthesis to DNA photodamage, and is a powerful tool in biomedicine for analytical, diagnostic and therapeutic purposes. The main goal of LightDyNAmics is to achieve a complete understanding of the ultrafast dynamical processes at the molecular scale induced by UV light absorption in DNA, and to unveil the mechanisms leading to photodamage of the genetic code. At the same time, our project will transfer this knowledge on light-matter interaction to a broad class of optoelectronic materials, highly relevant for Europe`s high-tech industries.
LightDyNAmics is an academia-industry research environment training 15 Early Stage Researchers (ESRs) by crossing the traditional border between theoretical and experimental expertise. This will be achieved by performing independent, yet interrelated and complementary research projects focussed on photoactivated dynamics of DNA, and by developing a variety of new spectroscopic and computational methods. For all the ESRs, personalised training in advanced techniques will be combined with a broad common interdisciplinary background on dynamical processes in bio-macromolecules.
The consortium brings together 10 leading academic groups with multidisciplinary expertise (chemistry, physics, biology) and a unique blend of experimental and computational skills. 6 innovative companies, from SMEs specialised in click-chemistry and in biosensors to a pharma industry, will be fully integrated in the research and training programme and help promote technological exploitation of its results.
LightDyNAmics will develop innovative molecular probes for DNA/protein interaction, paving the way to new diagnostic tools and new drugs. The understanding of light interaction with organic molecules will impact on basic sciences, from biochemistry to nanosciences, and on industrial applications ranging from healthcare to photonic technologies.

Programme(s)

H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers

Topic(s)

MSCA-ITN-2017 - Innovative Training Networks

Call for proposal

H2020-MSCA-ITN-2017

See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE

Address

Piazzale Aldo Moro 7
00185 Roma

Italy

Activity type

Research Organisations

EU Contribution

€ 516 122,64

Website

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Participants (12)

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 262 875,60

UNIVERSITY OF DURHAM

United Kingdom

EU Contribution

€ 273 287,88

KEMIJSKI INSTITUT

Slovenia

EU Contribution

€ 234 997,56

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 498 432,96

Masarykova univerzita

Czechia

EU Contribution

€ 232 422,48

POLITECNICO DI MILANO

Italy

EU Contribution

€ 258 061,32

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

EU Contribution

€ 265 674,60

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA

Italy

EU Contribution

€ 258 061,32

UNIVERSITAT WIEN

Austria

EU Contribution

€ 255 934,08

ASTRAZENECA UK LIMITED

United Kingdom

EU Contribution

€ 273 287,88

BASECLICK GMBH

Germany

EU Contribution

€ 249 216,48

DYNAMIC BIOSENSORS GMBH

Germany

EU Contribution

€ 249 216,48

Partners (4)

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ACCELOPMENT AG

E4 COMPUTER ENGINEERING SPA

MOLECULAR DISCOVERY LTD

Prigen Srl

Project information

Grant agreement ID: 765266

Status

Ongoing project

  • Start date

    1 April 2018

  • End date

    31 March 2022

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 827 591,28

  • EU contribution

    € 3 827 591,28

Coordinated by:

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

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Last update: 31 August 2017

Record number: 211887