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DNA as a training platform for photodynamic processes in soft materials

Objective

Light interaction with biomaterials is the driving mechanism of fundamental biological processes, from photosynthesis to DNA photodamage, and is a powerful tool in biomedicine for analytical, diagnostic and therapeutic purposes. The main goal of LightDyNAmics is to achieve a complete understanding of the ultrafast dynamical processes at the molecular scale induced by UV light absorption in DNA, and to unveil the mechanisms leading to photodamage of the genetic code. At the same time, our project will transfer this knowledge on light-matter interaction to a broad class of optoelectronic materials, highly relevant for Europe`s high-tech industries.
LightDyNAmics is an academia-industry research environment training 15 Early Stage Researchers (ESRs) by crossing the traditional border between theoretical and experimental expertise. This will be achieved by performing independent, yet interrelated and complementary research projects focussed on photoactivated dynamics of DNA, and by developing a variety of new spectroscopic and computational methods. For all the ESRs, personalised training in advanced techniques will be combined with a broad common interdisciplinary background on dynamical processes in bio-macromolecules.
The consortium brings together 10 leading academic groups with multidisciplinary expertise (chemistry, physics, biology) and a unique blend of experimental and computational skills. 6 innovative companies, from SMEs specialised in click-chemistry and in biosensors to a pharma industry, will be fully integrated in the research and training programme and help promote technological exploitation of its results.
LightDyNAmics will develop innovative molecular probes for DNA/protein interaction, paving the way to new diagnostic tools and new drugs. The understanding of light interaction with organic molecules will impact on basic sciences, from biochemistry to nanosciences, and on industrial applications ranging from healthcare to photonic technologies.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/dna

Call for proposal

H2020-MSCA-ITN-2017
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Address
Piazzale Aldo Moro 7
00185 Roma
Italy
Activity type
Research Organisations
EU contribution
€ 516 122,64

Participants (12)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 262 875,60
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
UNIVERSITY OF DURHAM
United Kingdom
EU contribution
€ 273 287,88
Address
Stockton Road The Palatine Centre
DH1 3LE Durham
Activity type
Higher or Secondary Education Establishments
KEMIJSKI INSTITUT
Slovenia
EU contribution
€ 234 997,56
Address
Hajdrihova 19
1000 Ljubljana
Activity type
Research Organisations
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 498 432,96
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Masarykova univerzita
Czechia
EU contribution
€ 232 422,48
Address
Zerotinovo Namesti 9
60177 Brno Stred
Activity type
Higher or Secondary Education Establishments
POLITECNICO DI MILANO
Italy
EU contribution
€ 258 061,32
Address
Piazza Leonardo Da Vinci 32
20133 Milano
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 265 674,60
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 258 061,32
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT WIEN
Austria
EU contribution
€ 255 934,08
Address
Universitatsring 1
1010 Wien
Activity type
Higher or Secondary Education Establishments
ASTRAZENECA UK LIMITED
United Kingdom
EU contribution
€ 273 287,88
Address
1 Francis Crick Avenue Cambridge Biomedical Campus
CB2 0AA Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BASECLICK GMBH
Germany
EU contribution
€ 249 216,48
Address
Floriansbogen 2-4
82061 Neuried
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DYNAMIC BIOSENSORS GMBH
Germany
EU contribution
€ 249 216,48
Address
Lochhamer Strasse 15
82152 Martinsried
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (4)

ACCELOPMENT SCHWEIZ AG
Switzerland
Address
Seefeldstrasse 198
8008 Zurich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
E4 COMPUTER ENGINEERING SPA
Italy
Address
Via Martiri Della Liberta 66
42019 Scandiano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MOLECULAR DISCOVERY LTD
United Kingdom
Address
Marsh Road 215 Pinner
HA5 5NE London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Prigen Srl
Italy
Address
Via Anita Garibaldi 1
20052 Monza
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)