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Analytics for Biologics

Objective

Qualitative and quantitative analysis and purification of therapeutic protein species (TP-S) – coded by the same gene, thus chemically often very similar – is one of the most challenging problems in analytical chemistry today. This problem is of huge impact in the area of therapeutic proteins (TPs) – a rapidly growing market – causing a high demand in specialists in the field of TP manufacturing. This demand can currently not be met by single European universities. In an Europe-wide joint research and training network the graduate school A4B will offer a specific training program yielding the required specialists. A4B-PhD students will develop solutions for the most urgent problems in TP production and analysis.
Production of TPs is associated with the generation of poorly effective or even harmful species. For an effective removal of these species, A4B-students will develop improved purification methods based on advanced affinity and displacement chromatography. For controlling effectiveness and design of experiments, fast and reliable qualitative and quantitative detection methods are required. The development of these analytical methods will focus on the chemical composition of TP-S including their glycans and other posttranslational modifications (PTMs). We will use high-end electrophoretic, liquid chromatographic, and mass spectrometry approaches in combination with bioinformatics. The developed methods will be tested and used for improving protein production processes and therapy control.
All A4B students will receive a basic education in manufacturing and marketing of TPS. Through their research projects the students will develop in depth expertise in one of the areas covered by the consortium. This project will thus generate urgently needed new methods for an improved analysis and purification of TP-S, while at the same time ensuring that well qualified young researchers are available for this rapidly growing area of the pharmaceutical industry.

Call for proposal

H2020-MSCA-ITN-2017
See other projects for this call

Coordinator

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Address
Martinistrasse 52
20251 Hamburg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 498 432,96

Participants (10)

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 249 216,48
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 263 659,32
Address
Brinellvagen 8
100 44 Stockholm
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS LEIDEN - LEIDS UNIVERSITAIR MEDISCH CENTRUM
Netherlands
EU contribution
€ 510 748,56
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
SYDDANSK UNIVERSITET
Denmark
EU contribution
€ 290 081,88
Address
Campusvej 55
5230 Odense M
Activity type
Higher or Secondary Education Establishments
LUDGER LIMITED
United Kingdom
EU contribution
€ 273 287,88
Address
Culham Science Centre - Building E1
OX14 3EB Abingdon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 510 748,56
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments
UNIVERSITETET I OSLO
Norway
EU contribution
€ 286 275,24
Address
Problemveien 5-7
0313 Oslo
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET FUER BODENKULTUR WIEN
Austria
EU contribution
€ 511 868,16
Address
Gregor Mendel Strasse 33
1180 Wien
Activity type
Higher or Secondary Education Establishments
ALPHALYSE A/S
Denmark
EU contribution
€ 290 081,88
Address
Unsbjergvej 4
5220 Odense
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HEXAL AKTIENGESELLSCHAFT
Germany
EU contribution
€ 249 216,48
Address
Industriestr. 25
83607 Holzkirchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)