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Super-resolution optical microscopy of nanosized pore dynamics in endothelial cells

Objective

DeLIVER will train a new generation of ESRs in the development and application of newly developed high speed and high resolution imaging tools in biomedical research. ESRs will be cross-pollinated with concepts and skills in physics and biomedicine, in particular in super-resolution optical imaging (a.k.a. optical nanoscopy), analytical image reconstruction, and optical micro-manipulation methods. These skills are applied to reveal for the first time the function and dynamics of nanosized pores in endothelial cells (EC) that present the main barrier between the blood and vital organs for human physiology, such as the liver, brain, kidneys, and the eyes. Very little is known about the extremely important physiological function of these unique structures and their role in the transfer and/or clearance of metabolites and pharmaceuticals to vital organs. The current generation of optical nanoscopes, however, is rather slow and can only be applied to isolated, typically fixed (i.e. dead) cells rather than biomedically relevant tissues. Also, newcomers to the field need to familiarize themselves with a whole new set of potential problems that might arise in the use of optical nanoscopy, such as image reconstruction-related artifacts to name just one example.This is an area of research where European enterprises are very active. Excellent training in new scientific and complementary skills, combined with international and intersectoral work experience, will instil an innovative, creative and entrepreneurial mind-set in DeLIVER's ESRs, maximising economic benefits based on scientific discoveries. These specialised, highly trained, and mobile ESRs will have greatly enhanced career prospects. The training in novel physical methods with highly relevant experience in the biomedical sciences will allow them to confidently navigate at the interface of academic, clinical and private sector research.

Call for proposal

H2020-MSCA-ITN-2017
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Coordinator

UNIVERSITAET BIELEFELD
Address
Universitaetsstrasse 25
33615 Bielefeld
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 747 649,44

Participants (8)

UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET
Norway
EU contribution
€ 1 145 100,96
Address
Hansine Hansens Veg 14
9019 Tromso
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 273 287,88
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 263 659,32
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 273 287,88
Address
Edgbaston
B15 2TT Birmingham
Activity type
Higher or Secondary Education Establishments
VRIJE UNIVERSITEIT BRUSSEL
Belgium
EU contribution
€ 250 560
Address
Pleinlaan 2
1050 Brussel
Activity type
Higher or Secondary Education Establishments
LAVISION BIOTEC GMBH
Germany
EU contribution
€ 249 216,48
Address
Astastrasse 14
33617 Bielefeld
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CHERRY BIOTECH
France
EU contribution
€ 262 875,60
Address
2Eme Etage, Halls A-b Et C14 Rue De La Beaune
93100 Montreuil
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ELVESYS
France
EU contribution
€ 262 875,60
Address
172 Rue De Charonne B2 2 Eme Etage
75011 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (5)

BAYER AKTIENGESELLSCHAFT
Germany
Address
Kaiser-wilhelm-allee 1
51373 Leverkusen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Norinnova Technology Transfer AS
Norway
Address
Sykehusvegen 23
9294 Tromsø
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ANZAC HEALTH AND MEDICAL RESEARCH FOUNDATION
Australia
Address
Gate 3, Hospital Road,
2139 Concord Nsw
Activity type
Other
THE UNIVERSITY OF HONG KONG
Hong Kong
Address
Pokfulam Road
Pokfulam
Activity type
Higher or Secondary Education Establishments
United States Department of Health and Human Services
United States
Address
Independence Avenue S. W. 200
20201 Washington D.c.
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)