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EXPLORING THE NEUROLOGICAL EXPOSOME

EXPLORING THE NEUROLOGICAL EXPOSOME

Objective

The main objective of NEUROSOME is to develop an integrative biology-based framework starting from human biomonitoring data to unravel causal associations among the genetic predisposition, cumulative exposure to multiple environmental chemicals and neurological disorders. The project brings together beyond- the-state-of-the-art advances in human biomonitoring and systems biology, exposure monitoring and toxicological testing technologies and advanced tools for computational analyses of the exposure-to-health effect continuum following an exposome paradigm. The NEUROSOME methodology will be applied in population studies across different exposure settings to neurotoxicants (metals and persistent organics) in Europe. This will improve scientific knowledge on cause and-effect relations between environmental stressors and neurodevelopmental disorders taking into account exposure and health effect modification due to intrinsic (e.g. genetic susceptibility) and extrinsic (e.g. diet and socioeconomic status) factors. New standards for human biomonitoring data interpretation in conjunction with environmental and exposure information will be developed for ready use in chemical mixture risk assessment.
The training goal is to produce a new generation of exposome researchers, trained in academia, applied research and industry, with transdisciplinary skills (environmental end exposure modelling, human biomonitoring, -omics technologies, high dimensional bioinformatics and environmental epidemiology,) and understanding of fundamental science and its direct application to environmental health challenges. To this aim NEUROSOME will focus on the provision of trans-disciplinary research training to young researchers through a combination of network-wide training programs and individual personalised training-through-research projects to deliver to the EU and the world a new cohort of researchers trained in cutting edge transdisciplinary environmental health sciences
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Coordinator

ARISTOTELIO PANEPISTIMIO THESSALONIKIS

Address

Kedea Building, Tritis Septemvriou, Aristotle Univ Campus
54636 Thessaloniki

Greece

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 484 773,84

Participants (9)

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ISTITUTO SUPERIORE DI SANITA

Italy

EU Contribution

€ 516 122,64

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 247 872,96

INSTITUT JOZEF STEFAN

Slovenia

EU Contribution

€ 469 995,12

UNIVERSITE PARIS DESCARTES

France

EU Contribution

€ 262 875,60

UNIVERSITAT ROVIRA I VIRGILI

Spain

EU Contribution

€ 247 872,96

KENTRO TOXIKOLOGIAS ANONIMI ETAIRIA SYMVOULEYMKES DIAGNOSTIKES KAI ERGASTIRIAKES YPIRESIES TOXIKOLOGIAS FARMAKOLOGIAS KAI BIOIATRIKIS

Greece

EU Contribution

€ 242 386,92

ZELENA INFRASTRUKTURA DRUSTVO S OGRANICENOM ODGOVORNOSCU ZA ZASTITU OKOLISA I PROSTORNO UREDENJE

Croatia

EU Contribution

€ 247 761

Istituto Universitario di Studi Superiori di Pavia

Italy

EU Contribution

€ 516 122,64

ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO BURLO GAROFOLO

Italy

EU Contribution

€ 258 061,32

Partners (5)

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UPCOM BVBA

JOHNS HOPKINS UNIVERSITY

EMORY UNIVERSITY NON PROFIT CORP

Harvard Medical School

U.S. ENVIRONMENTAL PROTECTION AGENCY - EPA

Project information

Grant agreement ID: 766251

Status

Ongoing project

  • Start date

    1 October 2017

  • End date

    30 September 2021

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 493 845

  • EU contribution

    € 3 493 845

Coordinated by:

ARISTOTELIO PANEPISTIMIO THESSALONIKIS

Greece