CORDIS
EU research results

CORDIS

English EN
Microbial deployment of new-to-nature chemistries for refactoring the barriers between living and non-living matter

Microbial deployment of new-to-nature chemistries for refactoring the barriers between living and non-living matter

Objective

This Project is about bringing a suite of chemical reactions (and its related non-biological compounds and elements) to the biological fold (i.e. their 'biologization') by going beyond the Central Dogma of Molecular Biology (DNA→ RNA→ proteins→ metabolism) through both tuning and overcoming the uni-directionality of the information flow. To reverse-engineer reactions into a biological code, the utility function of the chemical process of interest will be progressively coupled to the fitness function of a live carrier (e.g. an engineered, synthetic or cyborg-ized bacterial chassis), the intermediate steps being supported by automated chemo-robots. The new-to-nature reactions (NTN) pursued within the MADONNA lifetime as case studies will include CO2 capture and recruitment of elemental silicon to become part of essential organo-Si metabolites. Along with the development of the new reactions, the research agenda of the Project will also include the [i] modelling and prediction on the impact of the new biotransformations on the overall functioning of the Biosphere once/if adopted at a large scale by the industrial sector and [ii] design of environmental simulators for evaluating the performance and evolution of the new biological reactions under given physico-chemical settings. With such approaches, MADONNA aims to fill many of the gaps between the 3 types of global-scale processing of chemical elements operating in our planet: Geochemical, Biological and Industrial. The scale of applications of the foundational technologies developed herein (which spin themselves much beyond CO2 and silicon) is unprecedented and a large number of societal ramifications including ethical, security, safety, economic, governance and public perceptions aspects at stake will be included. If successful, MADONNA will enable an entirely new type of sustainable industry in which many types of waste become assets instead of liabilities.

Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Address

Calle Serrano 117
28006 Madrid

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 526 713,75

Participants (8)

Sort alphabetically

Sort by EU Contribution

Expand all

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

EU Contribution

€ 439 327,50

UNIVERSITAT BASEL

Switzerland

EU Contribution

€ 429 413,75

Isthmus

France

EU Contribution

€ 327 500

UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

France

SORBONNE UNIVERSITE

France

EU Contribution

€ 100 227,50

UNIVERSITY OF GLASGOW

United Kingdom

EU Contribution

€ 421 875

Universitat Pompeu Fabra

Spain

EU Contribution

€ 313 450

BIOFACTION KG

Austria

EU Contribution

€ 410 310

Project information

Grant agreement ID: 766975

Status

Ongoing project

  • Start date

    1 January 2018

  • End date

    31 December 2021

Funded under:

H2020-EU.1.2.1.

  • Overall budget:

    € 2 968 817,50

  • EU contribution

    € 2 968 817,50

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain