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Advanced personalised, multi-scale computer models preventing OsteoArthritis

Objective

Osteoarthritis (OA) is a degenerative disease of the articular cartilage and the most common form of arthritis that causes joint pain, mobility limitation and, thus, reduces independence and overall quality of life. Although the usual population associated with the condition is the elderly (65 years old ranges from 12- 30%), who are mostly inactive, athletes and younger individuals are also susceptible. Whilst the available data have implicated the role of the various modifiable or non-modifiable risk factors in the development and progression of OA, no study has conclusively explored the interaction and integration of other information sets in a patient-specific manner. The current OACTIVE project intents to make a significant leap forward adopting a multi-scale holistic approach where patient-specific information from various levels, including cell, tissue, organ and whole body will be integrated and combined with information from other sources such as biochemical/inflammatory biomarkers, behaviour modeling and social/environmental risk factors to generate robust predictors for new personalised interventions for delaying onset and slowing down progression of OA. OACTIVE targets to patient-specific OA prediction and interventions by using a combination of mechanistic, phenomenological computational models, simulations and big data analytics. Once constructed, these models will be used to simulate and predict optimal treatments, better diagnostics, and improved patient outcomes. Overcoming the limitation of the current treatment interventions, Augmented Reality empowered interventions will be developed in a personalised framework allowing patients experience the treatment as more enjoyable, resulting in greater motivation, engagement, and training adherence. OACTIVE’s mission is to improve healthcare by transforming and accelerating the OA diagnosis and prediction based on a more comprehensive understanding of disease pathophysiology, dynamics, and patient outcomes.

Field of science

  • /medical and health sciences/basic medicine/physiology/pathophysiology
  • /natural sciences/computer and information sciences/data science/big data
  • /natural sciences/computer and information sciences/data science/data analysis

Call for proposal

H2020-SC1-2017-CNECT-2
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

EDEX - EDUCATIONAL EXCELLENCE CORPORATION LIMITED
Address
Makedonitisas Avenue 46
1700 Nicosia
Cyprus
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 521 000

Participants (12)

ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS
Greece
EU contribution
€ 506 875
Address
Charilaou Thermi Road 6 Km
57001 Thermi Thessaloniki
Activity type
Research Organisations
LIVERPOOL JOHN MOORES UNIVERSITY
United Kingdom
EU contribution
€ 444 721,25
Address
Rodney Street 2 Egerton Court
L3 5UX Liverpool
Activity type
Higher or Secondary Education Establishments
PANEPISTIMIO PATRON
Greece
EU contribution
€ 431 250
Address
University Campus Rio Patras
265 04 Rio Patras
Activity type
Higher or Secondary Education Establishments
SMARTEX S.R.L.
Italy
EU contribution
€ 456 062,50
Address
Via Lungo Il Ficarello 3
59100 Prato
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 354 062,50
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
CENTER FOR TECHNOLOGY RESEARCH ANDINNOVATION (CETRI) LTD
Cyprus
EU contribution
€ 477 000
Address
77, John Kennedy Avenue
1077 Nicosia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ACONDICIONAMIENTO TARRASENSE ASSOCIACION
Spain
EU contribution
€ 422 500
Address
Carrer De La Innovacio 2
08225 Terrassa
Activity type
Research Organisations
FONDAZIONE RI.MED
Italy
EU contribution
€ 399 062,50
Address
Via Bandiera 11
90133 Palermo
Activity type
Research Organisations
TIME.LEX
Belgium
EU contribution
€ 186 750
Address
Joseph Stevensstraat 7
1000 Brussel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AXIA INNOVATION UG
Germany
EU contribution
€ 248 750
Address
Zenettistrasse 49
80337 Munchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ANIMUS KENTRO APOTHERAPEIAS KAI APOKATASTASIS ANONYMI ETAIRIA
Greece
EU contribution
€ 218 750
Address
8 Km Larissa - Trikala
41500 Larissa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA
Spain
EU contribution
€ 317 250
Address
Av Fernando Abril Martorell 106
46026 Valencia
Activity type
Research Organisations