CORDIS

The overreaching goal of BOUNCE is to incorporate elements of a dynamic, predictive model of patient outcomes in building a decision-support system used in routine clinical practice to provide physicians and other health professionals with concrete, personalized recommendations regarding optimal psychosocial support strategies of early breast cancer patients.
There is a growing need for novel strategies to improve understanding and capacity to predict resilience of women to the variety of stressful experiences and practical challenges related to breast cancer. This is a necessary step toward efficient recovery through personalized interventions. BOUNCE will take into consideration clinical, cancer-related biological, lifestyle, and psychosocial parameters in order to predict individual resilience trajectories and eventually increase resilience in breast cancer survivors and help them to enjoy a better quality of life.
Objectives:
1.To survey personal, clinical, and biological measures available for existing patient cohorts developed by clinical partners, in order to construct a preliminary model of patient resilience and quality of life.
2.To construct a measurement model of patient resilience to the physical and emotional challenges associated with the disease itself and with the burden incurred by BC treatments using data from the clinical pilot.
3.To develop operational algorithms for predicting long-term patient outcomes by taking into account individual levels of resilience at each time point during the course of illness, as well as current/past biological, sociodemographic, psychosocial, personal, clinical, and life-style patient characteristics
4. To address long-standing issues in the field of psycho-oncology regarding the dynamics of time-varying relationships between determinants of resilience and disease outcomes.
5. To define measurable and potentially modifiable social, psychological, and lifestyle parameters that optimally define successful adaptation to BC-related stressors as determinants of long-term patient outcomes.
6.to ensure wide communication and scientific dissemination of the innovative BOUNCE results to the research, academic, and international community, the efficient exploitation and business planning of the BOUNCE concepts and tools to the market in order to identify end-users and potential customers, as well as the contribution of specific project results to relevant standardization bodies.