CORDIS
EU research results

CORDIS

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Driving the functional characterization of intrinsically disordered proteins

Project information

Grant agreement ID: 778247

Status

Ongoing project

  • Start date

    1 March 2018

  • End date

    28 February 2022

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 1 291 500

  • EU contribution

    € 1 291 500

Coordinated by:

UNIVERSITA DEGLI STUDI DI PADOVA

Italy

Objective

Intrinsically disordered proteins (IDPs), characterized by high conformational variability and interaction promiscuity, defy the classic protein structure-function paradigm. IDPs cover almost half of the residues in Eukaryotic proteomes. Growing evidence suggests that IDPs, interacting with multiple partners, are major players in cellular regulation and involved in numerous human diseases. Computational methods have contributed to the identification of IDPs from sequence and recently published curated IDP databases provide a starting point. However, functional knowledge for IDPs remains very limited.
IDPfun is an international consortium aiming to extend our knowledge on the functions of IDPs. Starting from available state of the art computational tools and databases, which have been mostly developed by IDPfun participants, it aims drive a new level of IDP characterization leverage the complementary expertise of 5 EU MS and 3 TC institutions in Argentina, the latter providing useful complementary expertises. IDPfun will create a collaborative environment for research on novel ways to detect and characterize different IDP phenomena in their evolutionary context. It will develop an ontology and classification facilitating the comprehension of IDP complexity and aims to understand IDP functional mechanisms. The gained knowledge will be translated into major international protein databases for the benefit of the wider scientific community. Periodic meetings and symposia will generate a continuous knowledge exchange to be disseminated by open training schools and conferences. IDPfun will foster particularly young researchers, through dedicated activities and by ensuring adherence to the highest quality, ethics and gender balance standards. It is expected that IDPfun will strengthen overseas collaborations, focusing and coordinating research, leading to the creation of a sustainable international IDP community, driving knowledge and infrastructure in bioinformatics.

Coordinator

UNIVERSITA DEGLI STUDI DI PADOVA

Address

Via 8 Febbraio 2
35122 Padova

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 423 000

Participants (4)

EOTVOS LORAND TUDOMANYEGYETEM

Hungary

EU Contribution

€ 207 000

VRIJE UNIVERSITEIT BRUSSEL

Belgium

EU Contribution

€ 234 000

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

EU Contribution

€ 193 500

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 234 000

Partners (3)

UNIVERSIDAD NACIONAL DE QUILMES

Argentina

FUNDACION INSTITUTO LELOIR

Argentina

UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN

Argentina

Project information

Grant agreement ID: 778247

Status

Ongoing project

  • Start date

    1 March 2018

  • End date

    28 February 2022

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 1 291 500

  • EU contribution

    € 1 291 500

Coordinated by:

UNIVERSITA DEGLI STUDI DI PADOVA

Italy