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A multidisciplinary approach for the stratification of patients with carotid artery disease

A multidisciplinary approach for the stratification of patients with carotid artery disease

Objective

Carotid artery disease, the primary trigger of ischaemic cerebrovascular events including stroke, causes major morbidity, mortality and healthcare costs worldwide. Still, treatment is based on criteria established in the 90s that do not take into account the molecular evolution we have witnessed since, nor the introduction of new medication, leading to remarkably high unnecessary surgical treatment while missing most patients at risk.
TAXINOMISIS will provide novel disease mechanism-based stratification for carotid artery disease patients to address the needs for stratified and personalised therapeutic interventions in the current era. This will be achieved through (1) the dissection of mechanisms mediating carotid artery disease, and identification of susceptibility and protection factors of plaque erosion and/or rupture using longitudinal cohorts and multi-omics, (2) the definition of distinct disease phenotypes and endotypes, and generation of molecular fingerprints of high versus low-risk states through systems medicine, (3) the development of a multilevel risk prediction model of the symptomatic plaque incorporating new biomarkers and advanced imaging, implemented in a software, to assist patient stratification and clinical decision making, (4) the development of novel pharmacogenomics solutions based on lab-on-a-chip technology to support personalized treatment, (5) the evaluation of the new risk prediction model and lab-on-a-chip device in a prospective observational clinical study, and (6) the assessment of regulatory, cost-effectiveness and ethical issues towards the implementation and commercialization of the programme’s outcomes.
TAXINOMISIS has therefore the potential to rationally change the current state-of-the-art in the stratification of patients with carotid artery disease by reducing unnecessary operations, refining medical treatment and opening up new avenues for therapeutic intervention, while strengthening the European biotechnology sector.

Coordinator

PANEPISTIMIO IOANNINON

Address

Panepistemioypole Panepistemio Ioanninon
45110 Ioannina

Greece

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 751 375

Participants (16)

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UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

EU Contribution

€ 816 656,25

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

Germany

EU Contribution

€ 302 500

FACULTY OF MEDICINE, UNIVERSITY OF BELGRADE

Serbia

EU Contribution

€ 350 000

INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM

Belgium

EU Contribution

€ 799 558,75

IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON

Greece

EU Contribution

€ 550 312,50

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 304 000

ZORA BIOSCIENCES OY

Finland

EU Contribution

€ 400 000

PIRKANMAA HOSPITAL DISTRICT

Finland

EU Contribution

€ 396 250

STICHTING NEDERLANDS INSTITUUT VOOR ONDERZOEK VAN DE GEZONDHEIDSZORG

Netherlands

EU Contribution

€ 183 750

IRCCS OSPEDALE POLICLINICO SAN MARTINO

Italy

EU Contribution

€ 218 750

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON

Greece

EU Contribution

€ 225 000

FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA

Spain

EU Contribution

€ 169 375

ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERING BIOIRC DOO

Serbia

EU Contribution

€ 181 250

Fair Dynamics Consulting s.r.l.

Italy

ENGINEERING - INGEGNERIA INFORMATICA SPA

Italy

EU Contribution

€ 291 250

EUROPEAN SOCIETY FOR CARDIOVASCULAR AND ENDOVASCULAR SURGERY

Switzerland

EU Contribution

€ 59 375

Project information

Grant agreement ID: 755320

Status

Ongoing project

  • Start date

    1 January 2018

  • End date

    31 December 2022

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 5 999 402,50

  • EU contribution

    € 5 999 402,50

Coordinated by:

PANEPISTIMIO IOANNINON

Greece