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A multidisciplinary approach for the stratification of patients with carotid artery disease

Objective

Carotid artery disease, the primary trigger of ischaemic cerebrovascular events including stroke, causes major morbidity, mortality and healthcare costs worldwide. Still, treatment is based on criteria established in the 90s that do not take into account the molecular evolution we have witnessed since, nor the introduction of new medication, leading to remarkably high unnecessary surgical treatment while missing most patients at risk.
TAXINOMISIS will provide novel disease mechanism-based stratification for carotid artery disease patients to address the needs for stratified and personalised therapeutic interventions in the current era. This will be achieved through (1) the dissection of mechanisms mediating carotid artery disease, and identification of susceptibility and protection factors of plaque erosion and/or rupture using longitudinal cohorts and multi-omics, (2) the definition of distinct disease phenotypes and endotypes, and generation of molecular fingerprints of high versus low-risk states through systems medicine, (3) the development of a multilevel risk prediction model of the symptomatic plaque incorporating new biomarkers and advanced imaging, implemented in a software, to assist patient stratification and clinical decision making, (4) the development of novel pharmacogenomics solutions based on lab-on-a-chip technology to support personalized treatment, (5) the evaluation of the new risk prediction model and lab-on-a-chip device in a prospective observational clinical study, and (6) the assessment of regulatory, cost-effectiveness and ethical issues towards the implementation and commercialization of the programme’s outcomes.
TAXINOMISIS has therefore the potential to rationally change the current state-of-the-art in the stratification of patients with carotid artery disease by reducing unnecessary operations, refining medical treatment and opening up new avenues for therapeutic intervention, while strengthening the European biotechnology sector.

Call for proposal

H2020-SC1-2017-Two-Stage-RTD
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Coordinator

PANEPISTIMIO IOANNINON
Address
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina
Greece
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 760 314,40

Participants (15)

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 808 685,29
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany
EU contribution
€ 290 029,04
Address
Ismaninger Strasse 22
81675 Muenchen
Activity type
Higher or Secondary Education Establishments
FACULTY OF MEDICINE, UNIVERSITY OF BELGRADE
Serbia
EU contribution
€ 371 841,54
Address
Dr Subotica, 8
11000 Belgrade
Activity type
Higher or Secondary Education Establishments
INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM
Belgium
EU contribution
€ 798 962,79
Address
Kapeldreef 75
3001 Leuven
Activity type
Research Organisations
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece
EU contribution
€ 549 716,54
Address
Soranou Efesiou 4
115 27 Athina
Activity type
Research Organisations
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 303 404,04
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
ZORA BIOSCIENCES OY
Finland
EU contribution
€ 399 404,04
Address
Tietotie 2 C
02150 Espoo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PIRKANMAA HOSPITAL DISTRICT
Finland
EU contribution
€ 395 654,04
Address
Teiskontie 35
33521 Tampere
Activity type
Research Organisations
STICHTING NEDERLANDS INSTITUUT VOOR ONDERZOEK VAN DE GEZONDHEIDSZORG
Netherlands
EU contribution
€ 183 154,04
Address
Otterstraat 118-124
3500 BN Utrecht
Activity type
Research Organisations
IRCCS OSPEDALE POLICLINICO SAN MARTINO
Italy
EU contribution
€ 191 279,04
Address
Largo Rosanna Benzi 10
16132 Genova
Activity type
Research Organisations
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
EU contribution
€ 252 091,55
Address
6 Christou Lada Str
10561 Athina
Activity type
Higher or Secondary Education Establishments
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spain
EU contribution
€ 164 779,04
Address
Carrer Rossello 149
08036 Barcelona
Activity type
Research Organisations
ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERING BIOIRC DOO
Serbia
EU contribution
€ 318 044,71
Address
Prvoslava Stojanovica Street 6
34000 Kragujevac
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ENGINEERING - INGEGNERIA INFORMATICA SPA

Participation ended

Italy
EU contribution
€ 153 263,36
Address
Piazzale Dell'agricoltura 24
00144 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EUROPAISCHER VEREIN FUR KARDIOVASKULARE UND ENDOVASKULARE CHIRURGIE
Switzerland
EU contribution
€ 58 779,04
Address
Dufourstrasse 32
000 Zurich
Activity type
Research Organisations