Skip to main content

Liquid biopsies and Imaging for improved cancer care

Objective

LIMA’s overall objective is to develop and validate technologies and tools to include liquid biopsies in the clinical workflow, aiming at introducing a more precise and dynamic genetic characterization of tumor at the diagnosis and during treatment phases. This will be done by combining molecular information from liquid biopsies and direct in-vivo tumor characterization from advanced MR imaging, taking into account the current clinical workflow.
The LIMA project will be based on following 5 conceptual pillars:
1. A robust method to measure and genomically analyze ct-DNA for tumor-driving mutations, which can be measured in a quantitative manner allowing therapy response prediction and monitoring.
2. A workflow for Circulating Tumor Cell isolation and computational model-based quantitative signal pathway analysis on single CTC mRNA expression levels. This allows for assessment of tumor heterogeneity in pathway activity (to relate back to tumor heterogeneity), targeted therapy response prediction and monitoring
3. Correlation of computational, model-based cancer pathway activity assessment from cancer tissue samples before and after neoadjuvant treatment and from liquid biopsies with MR imaging features.
4. Advance in MR imaging to better probe and image the cancer lesion and its microenvironment
5. Clinical analysis, correlating liquid biopsy/imaging –based results to clinical outcome, that is the response to (targeted drug) neoadjuvant therapy in selected breast cancer and rectal cancer patients.
These 5 pillars will be investigated in longitudinal observational studies that will follow patients undergoing neoadjuvant treatment (either chemotherapy or targeted therapy or the combination) for primary rectal and breast cancer. LIMA will demonstrate that prediction of drug therapy response, monitoring of response and detection of resistance can be improved over the current state of the art.

Call for proposal

H2020-SC1-2016-2017

See other projects for this call

Sub call

H2020-SC1-2017-Two-Stage-RTD

Coordinator

PHILIPS ELECTRONICS NEDERLAND BV
Net EU contribution
€ 813 093,75
Address
High Tech Campus 52
5656 AG Eindhoven
Netherlands

See on map

Region
Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00

Participants (10)

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
Net EU contribution
€ 1 606 347,50
Address
Heidelberglaan 100
3584 CX Utrecht

See on map

Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AGENA BIOSCIENCE GMBH
Germany
Net EU contribution
€ 517 742,50
Address
Gasstrasse 18, Haus 5
22761 Hamburg

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Hamburg Hamburg Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ALS AUTOMATED LAB SOLUTIONS GMBH
Germany
Net EU contribution
€ 547 145,00
Address
Otto-eppenstein-str. 30
07745 Jena

See on map

Region
Thüringen Thüringen Jena, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ANGLE EUROPE LIMITED
United Kingdom
Net EU contribution
€ 469 550,00
Address
Ground Floor 10 Nugent Road Surrey Research Park
GU2 7AF Guildford

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
South East (England) Surrey, East and West Sussex West Surrey
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 892 951,25
Address
Rue De Tolbiac 101
75654 Paris

See on map

Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

DIADX

Participation ended

France
Net EU contribution
€ 184 612,50
Address
62 Chemin Des Combelles
34270 Les Matelles

See on map

Region
Occitanie Languedoc-Roussillon Hérault
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
STILLA TECHNOLOGIES
France
Net EU contribution
€ 483 532,50
Address
1 Mail Du Professeur Georges Mathe
94800 Villejuif

See on map

Region
Ile-de-France Ile-de-France Val-de-Marne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
PHILIPS GMBH
Germany
Net EU contribution
€ 265 795,00
Address
Rontgenstrasse 22
22335 Hamburg

See on map

Region
Hamburg Hamburg Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
INSTITUT REGIONAL DU CANCER DE MONTPELLIER
France
Net EU contribution
€ 398 070,00
Address
Rue De La Croix Verte 31 Parc Euromedecine
34090 Montpellier

See on map

Region
Occitanie Languedoc-Roussillon Hérault
Activity type
Research Organisations
Non-EU contribution
€ 0,00
DIADX
France
Net EU contribution
€ 114 033,75
Address
62 Chemin Des Combelles
34270 Les Matelles

See on map

Region
Occitanie Languedoc-Roussillon Hérault
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00