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International Randomized Study Comparing personalized, Risk-Stratified to Standard Breast Cancer Screening In Women Aged 40-70

Objective

MyPeBS addresses the crucial and timely question of the future of breast cancer screening in Europe. Indeed current standard mammographic screening, with entry stratified by age alone, has recently been largely questioned. Despite a demonstrated mean 20% reduction in breast cancer-specific mortality, together with reduction of late-stage disease in women older than 50, it is associated with potential harms including false positive recalls and over-diagnosis.
Individual breast cancer risk estimation, through models including clinical variables, mammographic breast density and more than 100 genetic polymorphisms, now has substantial clinical and scientific bases. Personalized screening strategies, based on individual risk levels, could potentially improve the individual benefit/harms ratio of screening (earlier cancer detection and less intensive treatments in high risk women, less false positives and over-diagnoses in low risk ones), and increase the cost-efficacy for health insurances.
MyPEBS will conduct an international randomized phase III trial to validate this hypothesis. It will primarily assess the ability of an individual risk-based screening strategy to be non-inferior, and possibly superior, to the standard of care screening, in reducing the cumulative incidence of stage II+ breast cancers. The trial, conducted in 5 countries (France, Italy, UK, Belgium and Israel) will include 85000 European women aged 40-70, all followed for 4 years. MyPEBS will also evaluate if an individual risk-based screening strategy, compared with the standard, reduces screening-related harms (unnecessary biopsies, overdiagnoses) in low-risk women, is overall at least as cost-effective as well as more accepted by women resulting in a larger screening coverage. After analyses of all components, the final objective of MyPEBS is to deliver recommendations for the best future breast cancer screening strategy in Europe.

Call for proposal

H2020-SC1-2016-2017

See other projects for this call

Sub call

H2020-SC1-2017-Two-Stage-RTD

Coordinator

UNICANCER
Net EU contribution
€ 2 961 558,45
Address
101 Rue De Tolbiac
75013 Paris
France
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Ile-de-France Ile-de-France Paris
 

Participants (30)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

CENTRE GEORGES-FRANCOIS LECLERC ASSOCIATION

Participation ended

France
Net EU contribution
€ 12 878,55
Address
Rue Du Professeur Marion 1
21079 Dijon
Activity type
Other
Non-EU contribution
€ 0,00
Region
Bourgogne-Franche-Comté Bourgogne Côte-d’Or
 
INSTITUT GUSTAVE ROUSSY
France
Net EU contribution
€ 540 750,00
Address
Rue Camille Desmoulins 39
94805 Villejuif
Activity type
Research Organisations
Non-EU contribution
€ 0,00
THE UNIVERSITY OF MANCHESTER
United Kingdom
Net EU contribution
€ 304 057,90
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
North West (England) Greater Manchester Manchester
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Net EU contribution
€ 522 495,85
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
East of England East Anglia Cambridgeshire CC
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 394 312,50
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
Net EU contribution
€ 103 940,00
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
PREDILIFE
France
Net EU contribution
€ 309 181,74
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
39 Rue C. Desmoulins 1 Bat M. Tubiana Institut G. Roussy Igr Campus Cancer
94800 Villejuif
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Ile-de-France Ile-de-France Val-de-Marne
 
UNIVERSITE PARIS 13
France
Net EU contribution
€ 163 735,00
Address
Avenue Jean-baptiste Clement 99
93430 Villetaneuse
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Ile-de-France Ile-de-France Seine-Saint-Denis
AZIENDA UNITA SANITARIA LOCALE DI REGGIO EMILIA
Italy
Net EU contribution
€ 955 970,00
Address
Via Amendola 2
42100 Reggio Emilia
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
INSTITUT JULES BORDET ASBL
Belgium
Net EU contribution
€ 630 500,00
Address
Rue Meylemeersch, 90
1070 Anderlecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest
LOUGHBOROUGH UNIVERSITY

Participation ended

United Kingdom
Net EU contribution
€ 4 066,53
Address
Ashby Road
LE11 3TU Loughborough
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
East Midlands (England) Leicestershire, Rutland and Northamptonshire Leicestershire CC and Rutland
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
Net EU contribution
€ 25 000,00
Address
Franklin Street 1111 12 Floor
94607 Oakland Ca
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AZIENDA OSPEDALIERA CITTA DELLA SALUTE E DELLA SCIENZA DI TORINO
Italy
Net EU contribution
€ 584 130,00
Address
Corso Bramante 88 90
10126 Torino
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
AGENCE NATIONALE DE SANTE PUBLIQUE
France
Net EU contribution
€ 12 500,00
Address
12 Rue Du Val D'osne
94415 Saint Maurice
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
INDEPENDENT CANCER PATIENTS' VOICE
United Kingdom
Net EU contribution
€ 25 000,00
Address
17 Woodbridge Street
EC1R 0LL London
Activity type
Other
Non-EU contribution
€ 0,00
Region
London Inner London — East Haringey and Islington
 
IM3D SPA

Participation ended

Italy
Net EU contribution
€ 0,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Piazza Solferino 20
10121 Torino
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Nord-Ovest Piemonte Torino
 
ASSOCIATION EUROPEENNE DES LIGUES CONTRE LE CANCER ASBL
Belgium
Net EU contribution
€ 86 450,00
Address
Chaussee De Louvain 479
1030 Bruxelles
Activity type
Other
Non-EU contribution
€ 0,00
Region
Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest
 
COLLEGE NATIONAL DES GENERALISTES ENSEIGNANTS
France
Net EU contribution
€ 72 650,00
Address
3 Rue Parmentier
93100 Montreuil
Activity type
Other
Non-EU contribution
€ 0,00
Region
Ile-de-France Ile-de-France Seine-Saint-Denis
 
ASSUTA MEDICAL CENTERS LTD
Israel
Net EU contribution
€ 941 000,00
Address
Habarzel St 20 Ramat Hachayil
69710 Tel Aviv
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ISTITUTO ROMAGNOLO PER LO STUDIO DEI TUMORI DINO AMADORI - IRST SRL
Italy
Net EU contribution
€ 194 000,00
Address
Via Maroncelli 40
47014 Meldola
Activity type
Research Organisations
Non-EU contribution
€ 62 125,00
Region
Nord-Est Emilia-Romagna Forlì-Cesena
 
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

AZIENDA USL DELLA ROMAGNA
Italy
Net EU contribution
€ 41 250,00
Address
Via Alcide De Gasperi 8
48121 Ravenna
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
Region
Nord-Est Emilia-Romagna Ravenna
 
ISTITUTO PER LO STUDIO E LA PREVENZIONE E LA RETE ONCOLOGICA
Italy
Net EU contribution
€ 234 682,50
Address
Via Cosimo Il Vecchio 2
50139 Firenze
Activity type
Other
Non-EU contribution
€ 0,00
UNIVERSITE LYON 1 CLAUDE BERNARD
France
Net EU contribution
€ 158 735,00
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FONDATION ARC POUR LA RECHERCHE SUR LE CANCER
France
Net EU contribution
€ 6 250,00
Address
Rue Guy Moquet 9
94800 Villejuif
Activity type
Research Organisations
Non-EU contribution
€ 0,00
EONIX
Belgium
Net EU contribution
€ 565 000,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Boulevard Initialis 10
7000 Mons
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Région wallonne Prov. Hainaut Arr. Mons
 
FONDATION JEAN DAUSSET CENTRE D'ETUDE DU POLYMORPHISME HUMAIN FONDATION
France
Net EU contribution
€ 946 875,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Rue Juliette Dodu 27
75010 Paris 10
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Ile-de-France Ile-de-France Paris
 
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
Net EU contribution
€ 1 328 125,00
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Non-EU contribution
€ 0,00
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
Net EU contribution
€ 159 538,48
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
East Midlands (England) Derbyshire and Nottinghamshire Nottingham
INTUITIM
Belgium
Net EU contribution
€ 77 706,25
Address
Rue Pierre Dupont 200 B1
1140 Evere
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest
 
CONSORCIO MAR PARC DE SALUT DE BARCELONA
Spain
Net EU contribution
€ 74 520,00
Address
Paseo Maritim 25-29
08003 Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00