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International Randomized Study Comparing personalized, Risk-Stratified to Standard Breast Cancer Screening In Women Aged 40-70

Objective

MyPeBS addresses the crucial and timely question of the future of breast cancer screening in Europe. Indeed current standard mammographic screening, with entry stratified by age alone, has recently been largely questioned. Despite a demonstrated mean 20% reduction in breast cancer-specific mortality, together with reduction of late-stage disease in women older than 50, it is associated with potential harms including false positive recalls and over-diagnosis.
Individual breast cancer risk estimation, through models including clinical variables, mammographic breast density and more than 100 genetic polymorphisms, now has substantial clinical and scientific bases. Personalized screening strategies, based on individual risk levels, could potentially improve the individual benefit/harms ratio of screening (earlier cancer detection and less intensive treatments in high risk women, less false positives and over-diagnoses in low risk ones), and increase the cost-efficacy for health insurances.
MyPEBS will conduct an international randomized phase III trial to validate this hypothesis. It will primarily assess the ability of an individual risk-based screening strategy to be non-inferior, and possibly superior, to the standard of care screening, in reducing the cumulative incidence of stage II+ breast cancers. The trial, conducted in 5 countries (France, Italy, UK, Belgium and Israel) will include 85000 European women aged 40-70, all followed for 4 years. MyPEBS will also evaluate if an individual risk-based screening strategy, compared with the standard, reduces screening-related harms (unnecessary biopsies, overdiagnoses) in low-risk women, is overall at least as cost-effective as well as more accepted by women resulting in a larger screening coverage. After analyses of all components, the final objective of MyPEBS is to deliver recommendations for the best future breast cancer screening strategy in Europe.

Field of science

  • /medical and health sciences/clinical medicine/cancer/breast cancer

Call for proposal

H2020-SC1-2017-Two-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNICANCER
Address
101 Rue De Tolbiac
75013 Paris
France
Activity type
Research Organisations
EU contribution
€ 2 974 437

Participants (28)

INSTITUT GUSTAVE ROUSSY
France
EU contribution
€ 540 750
Address
Rue Camille Desmoulins 39
94805 Villejuif
Activity type
Research Organisations
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 304 057,90
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 522 495,85
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 394 312,50
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 103 940
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
PREDILIFE
France
EU contribution
€ 309 181,74
Address
39 Rue C. Desmoulins 1 Bat M. Tubiana Institut G. Roussy Igr Campus Cancer
94800 Villejuif
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITE PARIS 13
France
EU contribution
€ 163 735
Address
Avenue Jean-baptiste Clement 99
93430 Villetaneuse
Activity type
Higher or Secondary Education Establishments
AZIENDA UNITA SANITARIA LOCALE DI REGGIO EMILIA
Italy
EU contribution
€ 955 970
Address
Via Amendola 2
42100 Reggio Emilia
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
INSTITUT JULES BORDET
Belgium
EU contribution
€ 630 500
Address
Rue Heger Bordet 1
1000 Bruxelles
Activity type
Higher or Secondary Education Establishments
LOUGHBOROUGH UNIVERSITY

Participation ended

United Kingdom
EU contribution
€ 4 066,53
Address
Ashby Road
LE11 3TU Loughborough
Activity type
Higher or Secondary Education Establishments
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
EU contribution
€ 25 000
Address
Franklin Street 1111, 12 Floor
94607 Oakland Ca
Activity type
Higher or Secondary Education Establishments
AZIENDA OSPEDALIERA CITTA DELLA SALUTE E DELLA SCIENZA DI TORINO
Italy
EU contribution
€ 584 130
Address
Corso Bramante 88 90
10126 Torino
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
AGENCE NATIONALE DE SANTE PUBLIQUE
France
EU contribution
€ 12 500
Address
12 Rue Du Val D'osne
94415 Saint Maurice
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
INDEPENDENT CANCER PATIENTS' VOICE
United Kingdom
EU contribution
€ 25 000
Address
17 Woodbridge Street
EC1R 0LL London
Activity type
Other
IM3D SPA

Participation ended

Italy
EU contribution
€ 0
Address
Piazza Solferino 20
10121 Torino
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASSOCIATION EUROPEENNE DES LIGUES CONTRE LE CANCER ASBL
Belgium
EU contribution
€ 86 450
Address
Chaussee De Louvain 479
1030 Bruxelles
Activity type
Other
COLLEGE NATIONAL DES GENERALISTES ENSEIGNANTS
France
EU contribution
€ 72 650
Address
3 Rue Parmentier
93100 Montreuil
Activity type
Other
ASSUTA MEDICAL CENTERS LTD
Israel
EU contribution
€ 941 000
Address
Habarzel St 20 Ramat Hachayil
69710 Tel Aviv
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ISTITUTO SCIENTIFICO ROMAGNOLO PERLO STUDIO E LA CURA DEI TUMORI SRL
Italy
EU contribution
€ 235 250
Address
Via Maroncelli 40
47014 Meldola
Activity type
Research Organisations
ISTITUTO PER LO STUDIO E LA PREVENZIONE E LA RETE ONCOLOGICA
Italy
EU contribution
€ 234 682,50
Address
Via Cosimo Il Vecchio 2
50139 Firenze
Activity type
Other
UNIVERSITE LYON 1 CLAUDE BERNARD
France
EU contribution
€ 158 735
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
Activity type
Higher or Secondary Education Establishments
FONDATION ARC POUR LA RECHERCHE SUR LE CANCER
France
EU contribution
€ 6 250
Address
Rue Guy Moquet 9
94800 Villejuif
Activity type
Research Organisations
EONIX
Belgium
EU contribution
€ 565 000
Address
Boulevard Initialis 10
7000 Mons
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FONDATION JEAN DAUSSET CENTRE D'ETUDE DU POLYMORPHISME HUMAIN FONDATION
France
EU contribution
€ 946 875
Address
Rue Juliette Dodu 27
75010 Paris 10
Activity type
Research Organisations
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 1 328 125
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 159 538,48
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
INTUITIM
Belgium
EU contribution
€ 77 706,25
Address
Rue Pierre Dupont 200 B1
1140 Evere
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CONSORCIO MAR PARC DE SALUT DE BARCELONA
Spain
EU contribution
€ 74 520
Address
Paseo Maritim 25-29
08003 Barcelona
Activity type
Research Organisations