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Developing Multipurpose Nicotiana Crops for Molecular Farming using New Plant Breeding Techniques

Developing Multipurpose Nicotiana Crops for Molecular Farming using New Plant Breeding Techniques

Objective

A group of New Plant Breeding Techniques (NPBT) has opened unprecedented opportunities in agriculture. Those NPBTs are at least as efficient and often more precise than previous traditional and GM techniques, while circumventing the introduction of heritable transgenes from distant species in the plant genome. Properly communicated, NPBTs are expected to gain wide acceptance, especially when applied to breeding objectives which are seen as beneficial for the society. A well-perceived objective is Molecular Farming, which refers to the use of plants for the production of valuable biomolecules (e. g. biopharmaceuticals). Cultivated tobacco (Nicotiana tabacum) and its close Australian relative Nicotiana benthamiana, are preferred species in Molecular Farming due to their favourable features: non-food crops, easy tissue regeneration, high productivity, rich secondary metabolism and availability of genetic tools. In sharp contrast, traditional tobacco cultivation is in serious decline in the EU, causing serious social problems in many rural areas. NEWCOTIANA aims to revitalize those areas by breeding efficient Nicotiana biofactories of high-value non-smoking products as alternatives for traditional tobacco crops. NEWCOTIANA will develop the most advanced tobacco NPBTs toolbox, easily transferable to other plants. This will position EU in the avant-garde of breeding innovation. This toolbox will be used to create elite multipurpose Nicotiana varieties improved in product-specific traits (bioproduct quality, stability and yield), next to more general traits as biomass, resilience and biosafety. The “Newcotiana” varieties will be carefully tested in relevant pre-industrial environments for the production of end-value chemicals, namely proteins and metabolites for health and nutriceutical use. Ethical, social and legal aspects will be closely monitored and public and stakeholder engagement will be assured using innovative science communication methodologies.
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Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Address

Calle Serrano 117
28006 Madrid

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 702 581,25

Participants (18)

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ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE

United Kingdom

EU Contribution

€ 459 862,50

AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE

Italy

EU Contribution

€ 465 000

VIB

Belgium

EU Contribution

€ 359 475

ASOCIACION EMPRESARIAL DE INVESTIGACION CENTRO TECNOLOGICO NACIONAL AGROALIMENTARIO EXTREMADURA

Spain

EU Contribution

€ 292 107,50

UNIVERSITAET FUER BODENKULTUR WIEN

Austria

EU Contribution

€ 426 131,25

JOHN INNES CENTRE

United Kingdom

EU Contribution

€ 349 792,50

KARLSRUHER INSTITUT FUER TECHNOLOGIE

Germany

EU Contribution

€ 388 271,25

LEIBNIZ-INSTITUT FUR PFLANZENBIOCHEMIE

Germany

EU Contribution

€ 251 250

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 576 125

BIOFACTION KG

Austria

EU Contribution

€ 338 131,25

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 371 321,25

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany

EU Contribution

€ 495 513,75

Philip Morris Products S.A.

Switzerland

EU Contribution

€ 306 250

ST GEORGE'S HOSPITAL MEDICAL SCHOOL

United Kingdom

EU Contribution

€ 562 822,50

IDOASIS 2002 SL

Spain

EU Contribution

€ 343 875

QUEENSLAND UNIVERSITY OF TECHNOLOGY - QLD QUT

Australia

SESDERMA SL

Spain

EU Contribution

€ 191 987,50

NEUTRAL SUPPLY CHAIN LIMITED

United Kingdom

EU Contribution

€ 319 062,50

Project information

Grant agreement ID: 760331

Status

Ongoing project

  • Start date

    1 January 2018

  • End date

    30 June 2022

Funded under:

H2020-EU.2.1.4.

  • Overall budget:

    € 7 363 310

  • EU contribution

    € 7 199 560

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain