Skip to main content

Multimodal nanoparticles for structural and functional tracking of stem cell therapy on muscle regeneration

Objective

Cell therapy offers promising opportunities to approach several diseases for which no effective therapies are currently available. However, the prognosis of the treatment efficacy commonly only relies on the progression of the disease symptoms. There is a need of tools to evaluate and predict the safety and success of cell-based treatments in earlier stages. The current lack of methods providing real-time tracking of transplanted cells and knowledge on their early biodistribution and viability, is one of the major weakness of the available cell-based treatments.
The main goal of nTRACK is to develop a safe and highly sensitive multimodal nanoimaging agent enabling noninvasive, quantitative and longitudinal stem cell tracking and whole body biodistribution. nTRACK will also provide information on cell (long-term) viability using the combination of CT, MRI and PET, which are imaging modalities that are clinically available. The synthesis of nTRACK NPs and cellular labeling processes will be scaled up and will follow good manufacturing practice (GMP) requirements. A second goal is to establish a predictive model for early assessment of treatment effectiveness, based on short-term evaluation of the typical migration and biodistribution patterns of the stem cells. This predictive model could substantially improve overall management of the disease and will transform cell therapy treatment from “one size fits all’ concept towards personalised treatment.
The nTRACK technology will be demonstrated on a muscular injury sheep model, using imaging infrastructure commonly used in hospital settings. In addition, non-clinical safety studies on the nTRACK nanoparticles will be conducted following the conclusions of a series of formal interactions with regulatory authorities, to allow the prompt introduction into clinical trials after the end of the project.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /social sciences/sociology/social problems/migration

Call for proposal

H2020-NMBP-2017-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

ACONDICIONAMIENTO TARRASENSE ASSOCIACION
Address
Carrer De La Innovacio 2
08225 Terrassa
Spain
Activity type
Research Organisations
EU contribution
€ 1 415 437,50

Participants (12)

BAR ILAN UNIVERSITY
Israel
EU contribution
€ 787 356,25
Address
Bar Ilan University Campus
52900 Ramat Gan
Activity type
Higher or Secondary Education Establishments
PLURISTEM LTD
Israel
EU contribution
€ 487 500
Address
Matam Industrial Park Bldg 20
31905 Haifa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany
EU contribution
€ 631 588,75
Address
Langenbeckstrasse 1
55131 Mainz
Activity type
Higher or Secondary Education Establishments
MYBIOTECH GMBH
Germany
EU contribution
€ 436 871,25
Address
Industriestrasse 1B
66802 Uberherrn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MJR PHARMJET GMBH

Participation ended

Germany
EU contribution
€ 0
Address
Industriestrasse 1B
66802 Uberherrm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOEMISSION TECHNOLOGY SOLUTIONS IKE
Greece
EU contribution
€ 832 761,70
Address
Alexandras Avenue 116
114 72 Athina
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""

Participation ended

Greece
EU contribution
€ 55 875,30
Address
End Of Patriarchou Grigoriou E And 27 Neapoleos Street
15341 Agia Paraskevi
Activity type
Research Organisations
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
EU contribution
€ 1 019 687,50
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona
Activity type
Research Organisations
VIVOTECNIA RESEARCH SL
Spain
EU contribution
€ 454 681,25
Address
Calle Santiago Grisolia 2
28760 Tres Cantos - Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Netherlands
EU contribution
€ 269 747,50
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Activity type
Research Organisations
ASPHALION SL
Spain
EU contribution
€ 305 732,50
Address
Calle Tarragona, Numeros 151-157, Planta 10, Bloqu
08014 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CAMBRIDGE NANOMATERIALS TECHNOLOGY LTD
United Kingdom
EU contribution
€ 166 625
Address
Orchard Way, Lower Cambourne 14
CB23 5BN Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)