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Multimodal nanoparticles for structural and functional tracking of stem cell therapy on muscle regeneration

Objective

Cell therapy offers promising opportunities to approach several diseases for which no effective therapies are currently available. However, the prognosis of the treatment efficacy commonly only relies on the progression of the disease symptoms. There is a need of tools to evaluate and predict the safety and success of cell-based treatments in earlier stages. The current lack of methods providing real-time tracking of transplanted cells and knowledge on their early biodistribution and viability, is one of the major weakness of the available cell-based treatments.
The main goal of nTRACK is to develop a safe and highly sensitive multimodal nanoimaging agent enabling noninvasive, quantitative and longitudinal stem cell tracking and whole body biodistribution. nTRACK will also provide information on cell (long-term) viability using the combination of CT, MRI and PET, which are imaging modalities that are clinically available. The synthesis of nTRACK NPs and cellular labeling processes will be scaled up and will follow good manufacturing practice (GMP) requirements. A second goal is to establish a predictive model for early assessment of treatment effectiveness, based on short-term evaluation of the typical migration and biodistribution patterns of the stem cells. This predictive model could substantially improve overall management of the disease and will transform cell therapy treatment from “one size fits all’ concept towards personalised treatment.
The nTRACK technology will be demonstrated on a muscular injury sheep model, using imaging infrastructure commonly used in hospital settings. In addition, non-clinical safety studies on the nTRACK nanoparticles will be conducted following the conclusions of a series of formal interactions with regulatory authorities, to allow the prompt introduction into clinical trials after the end of the project.

Call for proposal

H2020-NMBP-2016-2017

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Sub call

H2020-NMBP-2017-two-stage

Coordinator

ACONDICIONAMIENTO TARRASENSE ASSOCIACION
Net EU contribution
€ 1 415 437,50
Address
Carrer De La Innovacio 2
08225 Terrassa
Spain

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 0,00

Participants (11)

BAR ILAN UNIVERSITY
Israel
Net EU contribution
€ 787 356,25
Address
Bar Ilan University Campus
52900 Ramat Gan

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
PLURI BIOTECH LTD
Israel
Net EU contribution
€ 487 500,00
Address
Matam Industrial Park Bldg 20
31905 Haifa

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany
Net EU contribution
€ 631 588,75
Address
Langenbeckstrasse 1
55131 Mainz

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Region
Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
MYBIOTECH GMBH
Germany
Net EU contribution
€ 436 871,25
Address
Industriestrasse 1b
66802 Uberherrn

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Saarland Saarland Saarlouis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
BIOEMISSION TECHNOLOGY SOLUTIONS IKE
Greece
Net EU contribution
€ 832 761,70
Address
L. Mesogeion 387
153 43 Agia Paraskevi (Athina)

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Βόρειος Τομέας Αθηνών Aττική Αττική
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,50
"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""

Participation ended

Greece
Net EU contribution
€ 55 875,30
Address
End Of Patriarchou Grigoriou E And 27 Neapoleos Street
15341 Agia Paraskevi
Region
Βόρειος Τομέας Αθηνών Aττική Αττική
Activity type
Research Organisations
Other funding
€ 0,00
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
Net EU contribution
€ 1 019 687,50
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 43 750,00
VIVOTECNIA RESEARCH SL
Spain
Net EU contribution
€ 454 681,25
Address
Calle Santiago Grisolia 2
28760 Tres Cantos - Madrid

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Netherlands
Net EU contribution
€ 269 747,50
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven

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Region
West-Nederland Utrecht Utrecht
Activity type
Research Organisations
Other funding
€ 0,00
ASPHALION SL
Spain
Net EU contribution
€ 305 732,50
Address
Calle Tarragona, Numeros 151-157, Planta 10, Bloqu
08014 Barcelona

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
CAMBRIDGE NANOMATERIALS TECHNOLOGY LTD
United Kingdom
Net EU contribution
€ 166 625,00
Address
Orchard Way, Lower Cambourne 14
CB23 5BN Cambridge

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
East of England East Anglia Cambridgeshire CC
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00