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InSilc: In-silico trials for drug-eluting BVS design, development and evaluation

Objective

The aim of InSilc is to develop an in-silico clinical trial (ISCT) platform for designing, developing and assessing drug-eluting bioresorbable vascular scaffolds (BVS), by building on the comprehensive biological and biomedical knowledge and advanced modelling approaches to simulate their implantation performance in the individual cardiovascular physiology. The InSilc platform is based on the extension of existing multidisciplinary and multiscale models for simulating the drug-eluting BVS mechanical behaviour, the deployment and degradation, the fluid dynamics in the micro- and macroscale, and the myocardial perfusion, for predicting its interaction with the vascular wall in the short- and medium/long term. InSilc goes beyond the design and development of ISCT and lays on the generation of in-silico models for obtaining quick and informed answers to several “What if” scenarios. “Virtual” patients would be given a “virtual” drug-eluting BVS, for observing the performance of the scaffold, assess and quantify the intended effect, with a deeper understanding than normal trials can provide. By integrating the information obtained from different in-silico predictive models, InSilc will: (i) assist in the development, assessment and optimization of the drug-eluting BVS and deliver accurate and reliable information to the Stent Biomedical Industry, (ii) assist the interventional Cardiologists in improving the surgical process of drug-eluting BVS implantation, support them in the clinical assessment and reduce the complications of suboptimal scaffold performance. By introducing computer simulations for establishing the safety and efficacy of drug-eluting BVS, InSilc aims to lower development costs and shorten time-to-market, reduce, refine, and partially replace human clinical trials through a more effective human clinical trials design, reduce the need for animal testing and result in a significant reduction of the associated direct and indirect costs.

Call for proposal

H2020-SC1-2017-CNECT-2
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Coordinator

IDRYMA TECHNOLOGIAS KAI EREVNAS
Address
N Plastira Str 100
70013 Irakleio
Greece
Activity type
Research Organisations
EU contribution
€ 822 365,60

Participants (12)

THE UNIVERSITY OF SHEFFIELD

Participation ended

United Kingdom
EU contribution
€ 98 000
Address
Firth Court Western Bank
S10 2TN Sheffield
Activity type
Higher or Secondary Education Establishments
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 805 580,40
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
POLITECNICO DI MILANO
Italy
EU contribution
€ 603 130,40
Address
Piazza Leonardo Da Vinci 32
20133 Milano
Activity type
Higher or Secondary Education Establishments
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 343 705,40
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
MEDIOLANUM CARDIO RESEARCH SRL
Italy
EU contribution
€ 259 330,40
Address
Piazza Giovine Italia 5
20123 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FEOPS NV
Belgium
EU contribution
€ 409 330,40
Address
Technologiepark Zwijnaarde 122
9052 Gent
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NATIONAL UNIVERSITY OF IRELAND GALWAY
Ireland
EU contribution
€ 566 155,40
Address
University Road
H91 Galway
Activity type
Higher or Secondary Education Establishments
ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERING BIOIRC DOO
Serbia
EU contribution
€ 363 080,40
Address
Prvoslava Stojanovica Street 6
34000 Kragujevac
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PANEPISTIMIO IOANNINON
Greece
EU contribution
€ 200 605,40
Address
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina
Activity type
Higher or Secondary Education Establishments
CBSET, INC
United States
EU contribution
€ 503 211,65
Address
500 Shire Way
02421 Lexington
Activity type
Research Organisations
BOSTON SCIENTIFIC LIMITED
Ireland
EU contribution
€ 305 580,40
Address
Ballybrit Business Park
H91 Galway
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 559 580,40
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments