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Hybrid Nanostructured Oligonucleotide Platforms for Biomedical Applications

Objective

Nanotechnology has received widespread attention in the last several decades due to the technological breakthroughs it has enabled across sectors from electronics to medicine. Towards the great challenges that nanotechnology arise, Nano-OligoMed has the ambition to establish and support a network of international collaboration, enabling a collaborative scientific team to effectively use a diversity of approaches and strategies to generate and test hybrid nanomaterials for the efficient and safe systemic delivery of oligonucleotide-based therapeutic agents. To this end, we have set-up a joint multidisciplinary scientific collaborative programme that through exchange, international mobility, and strongly collaborative transfer of knowledge and training activities between 4 European and 3 extra-European countries, will bring together leading experts under the field of “nanomaterials in biomedicine”. The scientific aim of Nano-OligoMed is the creation of degradable hybrid structures that combine the rigid, inert silica with the delicate programmable oligonucleotides or artificial oligonucleotide-mimics. The possibility to develop novel oligonucleotide-based materials will enable a) the degradation of the drug carrier at the presence of a specific input as a function of the intrinsic bio-responsive feature of oligonucleotides, b) the activation of a therapeutic function as a result of the bio-molecular interaction between the oligonucleotide-based material and the molecular target (i.e. miRNAs) and c) the delivery of the chemical payload (DNA and/or artificial mimics, even in combination with cancer drugs) upon cell internalization. The international academic networking, the broadening of the research skills, the educational activities, will provide to young (PhD students) and senior scientists, specific competences in the field of materials sciences, nanotechnology, molecular biology and molecular medicine.

Coordinator

UNIVERSITE DE STRASBOURG

Address

Rue Blaise Pascal 4
67081 Strasbourg

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 180 000

Participants (3)

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UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA

Italy

EU Contribution

€ 162 000

UNIVERSITA DEGLI STUDI DI PARMA

Italy

EU Contribution

€ 130 500

NANOMOL TECHNOLOGIES SL

Spain

EU Contribution

€ 126 000

Partners (3)

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ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY

UNIVERSIDAD DE LA HABANA

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Project information

Grant agreement ID: 778133

Status

Ongoing project

  • Start date

    1 December 2017

  • End date

    30 November 2021

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 598 500

  • EU contribution

    € 598 500

Coordinated by:

UNIVERSITE DE STRASBOURG

France