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Engineered bacterial Outer Membrane Vesicles (OMVs) for colorectal cancer immunotherapy

Objective

This proposal originates from recent results obtained in the course of the Advanced ERC Project “OMVac”, the scope of which is to exploit the unique adjuvanticity properties of bacterial Outer Membrane Vesicles (OMVs) for developing innovative vaccines against infectious diseases and cancer. In particular, Synthetic Biology was applied to engineer OMVs with FAT1, a tumour associated antigen expressed in most primary and metastatic colorectal cancers (CRC). Using cancer models in immunocompetent mice, immunization with FAT1-decorated OMVs inhibited subcutaneous growth of FAT1-positive CT26 cancer cells and protection correlated with an increase in tumour infiltration of CD4+/CD8+ T cells and concomitant decrease of Treg and MDSCs. These promising results prompted the submission of the present proposal which has as main objectives: 1) the demonstration that FAT1-OMV immunization can synergise with the protective activity of checkpoint inhibitors, and 2) the development of a scalable FAT1-OMV production and purification process which could allow testing FAT1-OMV/checkpoint inhibitor combination in the clinical setting.
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Host institution

UNIVERSITA DEGLI STUDI DI TRENTO

Address

Via Calepina 14
38122 Trento

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 93 750

Beneficiaries (2)

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UNIVERSITA DEGLI STUDI DI TRENTO

Italy

EU Contribution

€ 93 750

FONDAZIONE TOSCANA LIFE SCIENCES

Italy

EU Contribution

€ 56 250

Project information

Grant agreement ID: 780417

Status

Closed project

  • Start date

    1 January 2018

  • End date

    30 June 2019

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 150 000

  • EU contribution

    € 150 000

Hosted by:

UNIVERSITA DEGLI STUDI DI TRENTO

Italy