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Mid-infrared arthroscopy innovative imaging system for real-time clinical in depth examination and diagnosis of degenerative joint diseases

Objective

MIRACLE will take towards commercialization the first mid-infrared (MIR) arthroscopy probe for in-depth evaluation of articular cartilage enabling early diagnosis of degenerative joint diseases such as osteoarthritis (OA). The proposed device is intended for use during a minimally invasive surgery (arthroscopy). Currently, the surgeon’s decision-making is based on visual inspection and manual probing of the cartilage tissue which is highly subjective and of poor repeatability. Untreated or not-correctly treated joint injury will most likely progress towards OA, which will lead to joint pain, movement limitation, joint failure, and ultimately disability and joint replacement. OA constitutes a major challenge for the health systems and affects 242 million people globally. Moreover, OA is highly prevalent in Europe with an estimated 19.7-42.3% in the elderly population. MIRACLE concept is to access the biochemical on articular cartilage, which precedes OA. The feasibility of this approach as a diagnostic method has been demonstrated by MIRACLE consortium (TRL4). MIRACLE has also prototyped a MIR-probe with potential use for diagnostics (TRL4). By technology development reaching TRL 6-7, MIRACLE will bring to the arthroscopy market the first MIR-based probe providing an unique, accurate and quantitative diagnostic tool for the orthopedic surgeon. This will be achieved combining three novel photonics components: (i) a quantum cascade laser array tailored to biodiagnostics, (ii) an on-chip beam combiner for efficient radiation coupling, and (iii) MIR sensing probe for imaging. These components will be integrated in a medical device to be placed in the arthroscopy market (valued at $4 billion in 2015). In addition to add value to the European medical equipment industry, MIRACLE strives towards cost reduction of OA patients (currently costs/patient/year €10,452) contributing to more affordable public health care and promoting wellbeing in the European ageing population.

Call for proposal

H2020-ICT-2016-2017

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Sub call

H2020-ICT-2017-1

Coordinator

OULUN YLIOPISTO
Net EU contribution
€ 1 182 764,73
Address
Pentti Kaiteran Katu 1
90014 Oulu
Finland

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Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Pohjanmaa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (13)

UNIVERSITAET ULM
Germany
Net EU contribution
€ 875 252,00
Address
Helmholtzstrasse 16
89081 Ulm

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Region
Baden-Württemberg Tübingen Ulm, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ITA-SUOMEN YLIOPISTO
Finland
Net EU contribution
€ 585 856,25
Address
Yliopistonranta 1 E
70211 Kuopio

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Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Savo
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET
Norway
Net EU contribution
€ 558 431,25
Address
Universitetstunet 3
1433 As

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Region
Norge Oslo og Viken Viken
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
POHJOIS-SAVON SAIRAANHOITOPIIRIN KUNTAYHTYMA
Finland
Net EU contribution
€ 123 472,11
Address
Pl 100
70029 Kys

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Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Savo
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITEIT UTRECHT
Netherlands
Net EU contribution
€ 201 052,04
Address
Heidelberglaan 8
3584 CS Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
NANOPLUS NANOSYSTEMS AND TECHNOLOGIES GMBH
Germany
Net EU contribution
€ 853 030,75
Address
Oberer Kirschberg 4
97218 Gerbrunn

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Unterfranken Würzburg, Landkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 365 584,61
OPTOPRECISION GMBH
Germany
Net EU contribution
€ 495 615,60
Address
Auf Der Hoehe 15
28357 Bremen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bremen Bremen Bremen, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 212 406,68
IRIS TECHNOLOGY SOLUTIONS, SOCIEDAD LIMITADA
Spain
Net EU contribution
€ 352 450,00
Address
Carretera D Esplugues 39 41
08940 Cornella De Llobregat

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 151 050,00
ART PHOTONICS
Germany
Net EU contribution
€ 320 687,50
Address
Rudower Chaussee 46
12489 Berlin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 137 437,50
INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA
Portugal
Net EU contribution
€ 320 845,90
Address
Rua Alfredo Allen 208
4200 135 Porto

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Region
Continente Norte Área Metropolitana do Porto
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ASOCIACION ESPANOLA DE NORMALIZACION
Spain
Net EU contribution
€ 79 965,25
Address
Calle Genova 6
28004 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Other
Non-EU contribution
€ 0,00
PHOTONICS FINLAND
Finland
Net EU contribution
€ 106 367,50
Address
Länsikatu 15
80110 Joensuu

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Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Karjala
Activity type
Other
Non-EU contribution
€ 0,00
UNIVERSIDADE CATOLICA PORTUGUESA
Portugal
Net EU contribution
€ 77 845,00
Address
Palma De Cima
1649 023 Lisboa

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00