CORDIS
EU research results

CORDIS

English EN
Stimulating mir-106b expression to regenerate the myocardium

Stimulating mir-106b expression to regenerate the myocardium

Objective

Most people who develop ischemic HF have (or had) an ischemic heart condition first (e.g. myocardial infarction, MI). Restoring damaged heart muscle tissue therefore represents a fundamental mechanistic strategy to treat HF. Cardiac regeneration after ischemic damage can be achieved by stimulating the proliferation of already existing (endogenous) cardiomyocytes rather than having to rely on the implantation of exogenous cells (i.e. stem cell therapy). Compelling evidence supports that expanding the endogenous cardiomyocyte proliferation capacity by gene therapy appears to represent a promising approach to achieve endogenous cardiac regeneration. Species of non-coding RNA molecules, microRNAs, have been demonstrated to stimulate cardiomyocyte proliferation and the recognition of microRNAs as potential regenerative targets marks a major step towards fundamentally new therapeutic concepts that SUMMA addresses in ischemic heart disease. In the context of the ERC-Starting Grant project CALMIRS, we identified the miR-106b~25 cluster with high potential as new target for therapy to stimulate regeneration of the heart by promoting cardiomyocyte proliferation. Within SUMMA, we aim to advance these valuable research results on microRNA cardiac gene therapy in mice towards commercial proof-of-concept. During this project, proof-of-concept efficacy studies in a large animal (e.g. porcine) model of cardiac ischemia will be performed, while simultaneously market research, IP strategy development and business development activities take place to maximize the value of the project’s results. Different business models will be studied in terms of market research, IP strategy and business development to eventually consolidate a commercial strategy and business case for presenting our business proposition to strategic partners or venture capitalists.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Host institution

UNIVERSITEIT MAASTRICHT

Address

Minderbroedersberg 4-6
6200 Md Maastricht

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 149 875

Beneficiaries (1)

Sort alphabetically

Sort by EU Contribution

Expand all

UNIVERSITEIT MAASTRICHT

Netherlands

EU Contribution

€ 149 875

Project information

Grant agreement ID: 768657

Status

Ongoing project

  • Start date

    1 February 2018

  • End date

    31 July 2019

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 149 875

  • EU contribution

    € 149 875

Hosted by:

UNIVERSITEIT MAASTRICHT

Netherlands