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IMaging-based CUSTOMised EYE diagnostics

IMaging-based CUSTOMised EYE diagnostics

Objective

Prevalent eye diseases, such as glaucoma, keratoconus, refractive errors, cataract, myopia and presbyopia, affect millions
worldwide, and only in Europe represent over €20 billion annual cost to society. Current screening tools rely on
morphological biomarkers based on corneal shape and optics, yet differences in biomechanical properties underlie and
precede disease development (i.e. keratoconus, ectasia risk) or affect standard markers (i.e. intraocular pressure in
glaucoma). IMCUSTOMEYE will develop new diagnostic paradigms for these vision-threatening conditions, with a direct
impact on their treatment. We will deploy new compact, easy-to-use, label-free non-invasive imaging-based instrumentation
for direct measurement of corneal biomechanical properties in patients. The technology is based on imaging concepts
brought from other disciplines into ophthalmology and, for the first time, applied in patients in vivo. Dynamic corneal imaging
based on air-puff stimulated Optical Coherence Tomography corneal deformation and acoustic stimulated phase sensitive
and nanosensitive Optical Coherence Tomography corneal vibrography will be coupled to corneal mechanical models to
estimate corneal elasticity and viscoelasticity parameters (isolated from other factors). Corneal biomechanical properties will
be used as biomarkers for in-depth diagnosis of keratoconus and ectasia risk, and to provide accurate estimates of
intraocular pressure in glaucoma diagnosis. Clinical validations in ophthalmology hospitals will demonstrate the diagnostic and treatment predictive potential of the customised optical and biomechanical eye models from patient-specific enabled by
the new technology. IMCUSTOMEYE will contribute to more effective, customised treatment of eye diseases and to
reinforce industrial leadership in the area of diagnostic imaging in ophthalmology.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Address

Calle Serrano 117
28006 Madrid

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 457 423,75

Participants (10)

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THE UNIVERSITY OF LIVERPOOL

United Kingdom

EU Contribution

€ 824 881,25

NATIONAL UNIVERSITY OF IRELAND GALWAY

Ireland

EU Contribution

€ 820 413,75

INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK

Poland

EU Contribution

€ 979 000

INSTITUTO OFTALMOLOGICO FERNANDEZ-VEGA SL

Spain

EU Contribution

€ 261 121

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 160 918,56

IROC SCIENCE TO INNOVATION AG

Switzerland

EU Contribution

€ 463 804,25

OCULUS OPTIKGERATE GESELLSCHAFT MITBESCHRANKTER HAFTUNG

Germany

EU Contribution

€ 286 328,88

2 EYES VISION SL

Spain

EU Contribution

€ 157 535

OPTIMO MEDICAL AG

Switzerland

EU Contribution

€ 280 612,50

MOORFIELDS EYE HOSPITAL NHS FOUNDATION TRUST

United Kingdom

EU Contribution

€ 239 630,19

Project information

Grant agreement ID: 779960

Status

Ongoing project

  • Start date

    1 January 2018

  • End date

    31 December 2021

Funded under:

H2020-EU.2.1.1.

  • Overall budget:

    € 6 552 841,25

  • EU contribution

    € 5 931 669,13

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain