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Next Generation instrument for in-depth mitochondrial status analyses

Next Generation instrument for in-depth mitochondrial status analyses

Objective

Mitochondrial dysfunctions are known to be responsible for a number of heterogenous human diseases, such as neurodegenerative disorders, cardiovascular disorders, neurometabolic diseases, cancer, obesity, etc. mitochondria-related research is a growing field, as establishing the mechanisms underlying these disorders is of utmost important for their understanding and treatment. Founded in 1992 in Innsbruck (Austria), Oroboros® produces the gold standard of Oxygraphs, i.e. advanced systems for the study of mitochondrial function, which are sold in 49 countries worldwide and are used by a large scientific network (> 570 labs). With NextGen-O2k project Oroboros® is taking one step further, providing the market with the first all-in-one (i.e. integrated) instrument that allows the simultaneous measurement of several essential parameters involved in mitochondrial functions. As of today, these parameters (such as O2 flux and concentration, membrane potential, Ca2+ uptake or reactive oxygen species formation) are measured by different instruments under different conditions. In addition, NextGen-O2k includes a novel Q-redox sensor that has never been exploited before, to accurately study the redox events in the mitochondria. Up to date, Oroboros® counts with 4 prototypes of this new NextGen-O2k product (each of which has different modules in them) which have been tested at laboratory scale. The main goal of NextGen-O2k is thus to finalise the upgrade, integration and validation of all the different modules in a single instrument, so as to be ready for commercialization. In this way, NextGen-O2k will enable a faster screening of mitochondrial dysfunctions and disease by researchers and clinicians. What’s more, this project will also boost the growth of Oroboros® itself, facilitating a 40% increase in personnel and overall revenues of €42 million in 3 years after market launch.

Coordinator

OROBOROS INSTRUMENTS GmbH

Address

Schopfstrasse 18
6020 Innsbruck

Austria

Activity type

Other

EU Contribution

€ 50 000

Project information

Grant agreement ID: 807889

  • Start date

    1 February 2018

  • End date

    31 May 2018

Funded under:

H2020-EU.2.1.5.

H2020-EU.2.1.3.

H2020-EU.2.3.1.

H2020-EU.2.1.2.

  • Overall budget:

    € 71 429

  • EU contribution

    € 50 000

Coordinated by:

OROBOROS INSTRUMENTS GmbH

Austria