Deciphering molecular pathways of circadian clock communication

Project Information

CIRCOMMUNICATION

Grant agreement ID: 770869

DOI 10.3030/770869

Project closed

EC signature date 22 February 2018

Start date 1 March 2018

End date 29 February 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 945,00

EU contribution € 1 999 945,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

Publications

Other (3)

Beyond circadian rhythms: emerging roles of ultradian rhythms in control of liver functions

Author(s): Gad Asher* and Bokai Zhu.
Published in: Hepatology, Issue 77(3), 2023, Page(s) 1022-1035
Publisher: AASLD
DOI: 10.1002/hep.32580

Circadian clocks' interactions with oxygen sensing and signalling

Author(s): Yaarit Adamovich, Vaishnavi Dandavate, Gad Asher
Published in: ACTA Physioloigca, Issue 234 (2), 2022
Publisher: Wiley
DOI: 10.1111/apha.13770

Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology

Author(s): Nityanand Bolshette, Hussam Ibrahim, Hans Reinke, Gad Asher
Published in: Nat Rev Gastroenterol Hepatol, 2023
Publisher: Nature
DOI: 10.1038/s41575-023-00792-1

Peer reviewed articles (10)

Input integration by the circadian clock exhibits nonadditivity and fold-change detection

Author(s): Gal Manella; Nityanand Bolshette; Marina Golik; Gad Asher
Published in: Proceedings of the National Academy of Sciences - PNAS, Issue 1, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2209933119

The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding

Author(s): Gal Manella, Elizabeth Sabath, Rona Aviram, Vaishnavi Dandavate, Saar Ezagouri, Marina Golik, Yaarit Adamovich and Gad Asher
Published in: Nature metabolism, 2021, ISSN 2522-5812
Publisher: Berlin : Springer Nature
DOI: 10.1038/s42255-021-00395-7

Ultradian rhythms of AKT phosphorylation and gene expression emerge in the absence of the circadian clock components Per1 and Per2

Author(s): Rona Aviram; Vaishnavi Dandavate; Gal Manella; Marina Golik; Gad Asher
Published in: PLoS Biology, Issue 3, 2021, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3001492

The human blood transcriptome exhibits time-of-day dependent response to hypoxia – lessons from the highest city in the world

Author(s): Gal Manella, Saar Ezagouri, Benoit Champigneulle, Jonathan Gaucher, Monique Mendelson, Emeline Lemarie, Emeric Stauffer, Aurélien Pichon, Connor A. Howe, Stéphane Doutreleau, Marina Golik, Samuel Verges and Gad Asher
Published in: Cell reports, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111213

Hypoxia induces a time- and tissue-specific response that elicits intertissue circadian clock misalignment

Author(s): Gal Manella, Rona Aviram, Nityanand Bolshette, Sapir Muvkadi, Marina Golik, David F. Smith, Gad Asher
Published in: Proceedings of the National Academy of Sciences, Issue 117/1, 2020, Page(s) 779-786, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1914112117

Clock proteins and training modify exercise capacity in a daytime-dependent manner

Author(s): Yaarit Adamovich, Vaishnavi Dandavate, Saar Ezagouri, Gal Manella, Ziv Zwighaft, Jonathan Sobel, Yael Kuperman, Marina Golik, Asher Auerbach, Maxim Itkin, Sergey Malitsky and Gad Asher
Published in: Proceedings of the National Academy of Sciences - PNAS, 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2101115118

Snapshot: The liver by day and by night

Author(s): Rona Aviram, Gal Manella and Gad Asher
Published in: Journal of Hepatology, 2021, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2021.01.011

Physiological and Molecular Dissection of Daily Variance in Exercise Capacity

Author(s): Saar Ezagouri, Ziv Zwighaft, Jonathan Sobel, Sébastien Baillieul, Stéphane Doutreleau, Benjamin Ladeuix, Marina Golik, Samuel Verges, Gad Asher
Published in: Cell Metabolism, Issue 30/1, 2019, Page(s) 78-91.e4, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2019.03.012

Oxygen and Carbon Dioxide Rhythms Are Circadian Clock Controlled and Differentially Directed by Behavioral Signals

Author(s): Yaarit Adamovich, Benjamin Ladeuix, Jonathan Sobel, Gal Manella, Adi Neufeld-Cohen, Mohammad H. Assadi, Marina Golik, Yael Kuperman, Ariel Tarasiuk, Maarten P. Koeners, Gad Asher
Published in: Cell Metabolism, Issue 29/5, 2019, Page(s) 1092-1103.e3, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2019.01.007

Circa-SCOPE: high-throughput, live single-cell imaging method for analysis of circadian clock resetting

Author(s): Gal Manella, Dan Aizik, Rona Aviram, Marina Golik and Gad Asher
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26210-1