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Design and photo-optimization of Photosensitizer for Human Health and Food security applications or “how light can save lives”

Objective

The development of active compounds that can efficiently fight microbial infections and cancer are of utmost importance for food security and human health, two main challenges for Europe. Tetrapyrrolic photosensitizers (PS) are good candidates to meet these expectations. These photo-excitable molecules induce cell death via the formation of oxygen reactive species (ROS) and present very low toxicity in the absence of light. They are already used in photodynamic therapy (PDT) for cancer or skin disease treatments or in photo-antimicrobial chemo-therapy (PACT). Unfortunately, the research and training are still largely fragmented in this field in Europe. Some scientific barriers have to be overcome to increase their efficacy, e.g. improvement of the excitation pathways, ROS production, specific cell targeting, Gram (-) bactericidal effect and prevention and/or eradication of biofilms. That is why the EJD Polythea project aims developing an integrated and multidisciplinary approach of PDT through the implementation of 10 PhD research projects. The Polythea consortium proposes to develop (i) new tetrapyrrolic PS for various types of PDT including anti-cancer, anti-bacterial, anti-inflammatory and immune-activating application, improving their photophysical and biological properties; and (ii) innovative bio-inspired drug carriers or supports.
In parallel, a joint doctorate structure gathering 5 countries will be created and a multidisciplinary and inter-sectorial training programme will be implemented through network events and secondments to non-academic partners. It will provide a common background on PDT to the ESRs and make them more valuable employees, effective at problem solving. Practical applications should come out of this project such as first aid bandages, new skin/anti-tumour treatments, self-sterilizing surfaces for food industry or prosthetic devices.
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Coordinator

UNIVERSITE DE LIMOGES

Address

FranÇOis Mitterrand 33
87032 Limoges

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 525 751,20

Participants (6)

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THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

Ireland

EU Contribution

€ 797 023,80

POLITECHNIKA WROCLAWSKA

Poland

EU Contribution

€ 224 137,44

UNIVERSITEIT VAN AMSTERDAM

Netherlands

EU Contribution

€ 255 374,28

UNIVERSIDADE DE COIMBRA

Portugal

EU Contribution

€ 238 356,36

UNIVERSITE DE NEUCHATEL

Switzerland

EU Contribution

€ 265 226,76

BIOEMISSION TECHNOLOGY SOLUTIONS IKE

Greece

EU Contribution

€ 242 386,92

Project information

Grant agreement ID: 764837

Status

Ongoing project

  • Start date

    1 January 2018

  • End date

    31 December 2021

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 2 548 256,76

  • EU contribution

    € 2 548 256,76

Coordinated by:

UNIVERSITE DE LIMOGES

France