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Crystal structures of PIN proteins - CrysPINs

Objective

The main goal of the “CrysPINS” project is to derive a model for the structure of PIN1 protein, starting with a loopless version (PIN1loopless), and optionally other PIN proteins, using techniques of molecular biology, biochemistry and crystallography. Members of PIN family are plant-specific auxin transporters, which play crucial role in plant morphogenesis, development and responses to the environment. Although it is well known that PIN proteins drive polar auxin transport, till nowadays the auxin research community is missing detailed functional and mechanistic models of these enigmatic transporters. My considerable experience from studying auxin metabolism and transport on the cellular and plant level, combined with the expertise at the University of Warwick in auxin recognition and the structural biology of mammalian membrane transporter proteins, makes it timely to move the science forward by a project focussed on the structure of PINs. My vision is that we will be able to develop a detailed molecular map of PINs together with associated pharmacophoric map for their substrates and inhibitors, a goal that will offer me an ideal system for further research focused on PINs auxin substrate specificity and transport capacity. On the way I will expect to reveal how the PINs are energized, and create links with the auxin herbicide industries to explore opportunities for collaborations on agro-pharmaceutical compound design.
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Coordinator

THE UNIVERSITY OF WARWICK

Address

Kirby Corner Road - University House
Cv4 8uw Coventry

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 183 454,80

Project information

Grant agreement ID: 792329

Status

Ongoing project

  • Start date

    1 August 2018

  • End date

    31 July 2020

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 183 454,80

  • EU contribution

    € 183 454,80

Coordinated by:

THE UNIVERSITY OF WARWICK

United Kingdom