Dynamic Activatable Fluorophores

Projektinformationen

DYNAFLUORS

ID Finanzhilfevereinbarung: 771443

DOI 10.3030/771443

EK-Unterschriftsdatum 17 April 2018

Startdatum 1 Juni 2018

Enddatum 31 Dezember 2024

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten € 1 986 650,00

EU-Beitrag € 1 986 650,00

Koordiniert durch

THE UNIVERSITY OF EDINBURGH
United Kingdom

Ziel

In DYNAFLUORS I will develop the first chemical toolbox for imaging in real time the activity of immune cells in tumours.
Although the management of cancer has improved over the years, the cure rates for patients with metastasis and advanced tumours remain low due to lack of appropriate therapies. Recent studies suggest that drugs empowering host immune cells (i.e. immunotherapies) are promising approaches for intractable tumours. However, there are no tools to visualise and understand how host immune cells stop cancer progression in vivo. This important unmet challenge drives the ambitious targets of this proposal.

Over the past 10 years, I have pioneered the development of chemical fluorophores that allow unparalleled analysis of biological systems. In this project, I will implement an innovative approach to unify cutting-edge methodologies in chemistry and biology and develop Dynamic Activatable Fluorophores (DYNAFLUORS) as a chemical toolbox with enhanced imaging capabilities over current technologies.

The cross-disciplinary and ambitious nature of this project will open multiple avenues for broad impact in many areas of chemistry as well as in basic biology, imaging and medicine. DYNAFLUORS will allow us to image, from the molecular level to human tissue, the activity of immune cells in tumours and the response to therapy in real time. This ground-breaking chemical platform will represent a step forward in the forefront of chemical imaging and will create new opportunities in the personalised management of cancer.

In the long term, DYNAFLUORS will become a transformative toolbox for monitoring disease in humans. The integration of functional fluorophores into imaging technologies to perform ‘optical biopsies’ in vivo and to create patient-specific drug-response assays has the potential to revolutionise the diagnosis, stratification and personalised treatment of disease.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › genetics › DNA
• medical and health sciences › basic medicine › immunology
• medical and health sciences › clinical medicine › oncology
• natural sciences › biological sciences › genetics › RNA
• natural sciences › chemical sciences

Schlüsselbegriffe

• Fluorescent probes
• optical imaging
• peptide chemistry
• cancer immunology

Programm/Programme

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Thema/Themen

• ERC-2017-COG - ERC Consolidator Grant

Aufforderung zur Vorschlagseinreichung

ERC-2017-COG

Finanzierungsplan

ERC-COG - Consolidator Grant

Gastgebende Einrichtung

THE UNIVERSITY OF EDINBURGH

• Netto-EU-Beitrag: € 1 986 650,00
• Adresse: OLD COLLEGE, SOUTH BRIDGE ; EH8 9YL Edinburgh ; Vereinigtes Königreich
• Region: Scotland › Eastern Scotland › Edinburgh
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 1 986 650,00

Begünstigte (1)

THE UNIVERSITY OF EDINBURGH

Vereinigtes Königreich

• Netto-EU-Beitrag: € 1 986 650,00
• Adresse: OLD COLLEGE, SOUTH BRIDGE ; EH8 9YL Edinburgh
• Region: Scotland › Eastern Scotland › Edinburgh
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 1 986 650,00