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Immunome project consortium for AutoInflammatory Disorders

Objective

Systemic autoinflammatory diseases (SAID) encompass several rare disorders characterised by extensive clinical and biological inflammation. SAID are caused by the dysregulation of the innate immune system. Due to numerous and unspecific symptoms, tentative diagnosis often leads to failure/delay and inadequate treatments. ImmunAID will deliver a method for rapid and accurate diagnosis across all the spectrum of SAID, in order to improve clinical management of SAID patients. Thanks to parallel analyses run on samples from more than 600 patients with monogenic or undiagnosed SAID collected throughout Europe, Immunaid will generate a unique and comprehensive set of data, based on unbiased multiomics approaches (gene, transcript, protein, microbiome), and hypothesis-driven assays exploring inflammasome, inflammation resolution and immune networks. A centralised data management strategy will enable to conduct integrated analyses for diagnostic biomarker identification. In a discovery phase, semi-supervised clustering of omics data will be combined to supervised analysis of pathway-related data to provide robust classification and strong link to clinical features/impact. The related biomarkers will further be validated externally on independent samples and cohorts. Overall, ImmunAID will disentangle the spectrum of SAID, and propose a new omics- and pathogenesis-based SAID classification associated to a clinical decision making algorithm implementable in daily practice. An efficient dissemination plan will target e.g. guideline-forming bodies, the medical community and patients with the help of the ERN RITA and with the objective of turning our results into clinical practice. To further support this, proactive innovation management will be implemented. To reach its ambitious goals, ImmunAID interdisciplinary consortium gathers high-level partners, including the founder of SAID concept, experts in omics science, immunology, bioinformatics, and involves clinicians and patient advocacy groups.

Call for proposal

H2020-SC1-2016-2017

See other projects for this call

Sub call

H2020-SC1-2017-Single-Stage-RTD

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Net EU contribution
€ 3 189 482,10
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (26)

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
Net EU contribution
€ 897 997,50
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
VIB VZW
Belgium
Net EU contribution
€ 1 256 880,00
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Net EU contribution
€ 704 966,25
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE
Belgium
Net EU contribution
€ 151 000,00
Address
Avenue De L Hopital 1
4000 Liege
Activity type
Research Organisations
Non-EU contribution
€ 0,00
KOBENHAVNS UNIVERSITET
Denmark
Net EU contribution
€ 342 500,00
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTITUT CURIE
France
Net EU contribution
€ 392 500,00
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
OWKIN FRANCE
France
Net EU contribution
€ 383 750,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
12 Rue Martel
75010 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Ile-de-France Ile-de-France Paris
 
AMBIOTIS
France
Net EU contribution
€ 621 250,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Canal Biotech 2 3 Rue Des Satellites
31400 Toulouse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Germany
Net EU contribution
€ 632 850,00
Address
Schlossplatz 2
48149 Muenster
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece
Net EU contribution
€ 796 250,00
Address
Soranou Efesiou 4
115 27 Athina
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Κεντρικός Τομέας Αθηνών Aττική Αττική
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 2 568 028,55
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITE DE GENEVE
Switzerland
Net EU contribution
€ 321 465,00
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Schweiz/Suisse/Svizzera Région lémanique Genève
UNIVERSITY OF LEEDS
United Kingdom
Net EU contribution
€ 981 028,46
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Yorkshire and the Humber West Yorkshire Leeds
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

THE LEEDS TEACHING HOSPITALS NATIONAL HEALTH SERVICE TRUST
United Kingdom
Net EU contribution
€ 11 200,00
Address
St James's University Hospital, Beckett Street
LS9 7TF Leeds
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
Region
Yorkshire and the Humber West Yorkshire Leeds
UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 35 750,00
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
London Inner London — West Camden and City of London
PANEPISTIMIO IOANNINON
Greece
Net EU contribution
€ 369 690,00
Address
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Ιωάννινα Ήπειρος Βόρεια Ελλάδα
UNIVERSITE DE LIEGE
Belgium
Net EU contribution
€ 1 087 053,75
Address
Place Du 20 Aout 7
4000 Liege
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FMF & AID GLOBAL ASSOCIATION
Switzerland
Net EU contribution
€ 93 750,00
Address
Schuracherstrasse 25A
8306 Bruttisellen
Activity type
Other
Non-EU contribution
€ 0,00
Region
Schweiz/Suisse/Svizzera Zürich Zürich
 
HACETTEPE UNIVERSITESI
Turkey
Net EU contribution
€ 32 740,00
Address
Hacettepe Universitesi Beytepe Kampusu Rektorluk Binasi
06800 Cankaya Ankara
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERZITETNI KLINICNI CENTER LJUBLJANA
Slovenia
Net EU contribution
€ 11 250,00
Address
Zaloska Cesta 002
1000 Ljubljana
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
HOSPITAL SANT JOAN DE DÉU
Spain
Net EU contribution
€ 44 000,00
Address
Paseo Sant Joan De Deu 2
08950 Esplugues De Llobregat
Activity type
Research Organisations
Non-EU contribution
€ 0,00
OSPEDALE PEDIATRICO BAMBINO GESU
Italy
Net EU contribution
€ 102 840,00
Address
Piazza Sant Onofrio 4
00165 Roma
Activity type
Research Organisations
Non-EU contribution
€ 0,00
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
Net EU contribution
€ 273 168,00
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK
France
Net EU contribution
€ 353 043,00
Address
5 Rue Watt
75013 Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

LUXEMBOURG INSTITUTE OF HEALTH
Luxembourg
Net EU contribution
€ 38 600,00
Address
Val Fleuri 84
1526 Luxembourg
Activity type
Research Organisations
Non-EU contribution
€ 0,00
MANDANOVA
France
Net EU contribution
€ 142 818,64
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
11 Rue Des Poetes
31320 Castanet-tolosan
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00