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Immunome project consortium for AutoInflammatory Disorders

Objective

Systemic autoinflammatory diseases (SAID) encompass several rare disorders characterised by extensive clinical and biological inflammation. SAID are caused by the dysregulation of the innate immune system. Due to numerous and unspecific symptoms, tentative diagnosis often leads to failure/delay and inadequate treatments. ImmunAID will deliver a method for rapid and accurate diagnosis across all the spectrum of SAID, in order to improve clinical management of SAID patients. Thanks to parallel analyses run on samples from more than 600 patients with monogenic or undiagnosed SAID collected throughout Europe, Immunaid will generate a unique and comprehensive set of data, based on unbiased multiomics approaches (gene, transcript, protein, microbiome), and hypothesis-driven assays exploring inflammasome, inflammation resolution and immune networks. A centralised data management strategy will enable to conduct integrated analyses for diagnostic biomarker identification. In a discovery phase, semi-supervised clustering of omics data will be combined to supervised analysis of pathway-related data to provide robust classification and strong link to clinical features/impact. The related biomarkers will further be validated externally on independent samples and cohorts. Overall, ImmunAID will disentangle the spectrum of SAID, and propose a new omics- and pathogenesis-based SAID classification associated to a clinical decision making algorithm implementable in daily practice. An efficient dissemination plan will target e.g. guideline-forming bodies, the medical community and patients with the help of the ERN RITA and with the objective of turning our results into clinical practice. To further support this, proactive innovation management will be implemented. To reach its ambitious goals, ImmunAID interdisciplinary consortium gathers high-level partners, including the founder of SAID concept, experts in omics science, immunology, bioinformatics, and involves clinicians and patient advocacy groups.

Field of science

  • /social sciences/economics and business/business and management/innovation management
  • /medical and health sciences/basic medicine/immunology

Call for proposal

H2020-SC1-2017-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 3 189 482,10

Participants (24)

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 897 997,50
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
VIB VZW
Belgium
EU contribution
€ 1 256 880
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 704 966,25
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE
Belgium
EU contribution
€ 151 000
Address
Sart Tilman B35
4000 Liege
Activity type
Research Organisations
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 342 500
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
INSTITUT CURIE
France
EU contribution
€ 392 500
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
OWKIN FRANCE
France
EU contribution
€ 383 750
Address
12 Rue Martel
75010 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AMBIOTIS
France
EU contribution
€ 621 250
Address
Canal Biotech 2 3 Rue Des Satellites
31400 Toulouse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Germany
EU contribution
€ 632 850
Address
Schlossplatz 2
48149 Muenster
Activity type
Higher or Secondary Education Establishments
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece
EU contribution
€ 796 250
Address
Soranou Efesiou 4
115 27 Athina
Activity type
Research Organisations
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 2 568 028,55
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 321 465
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 992 228,46
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 35 750
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
PANEPISTIMIO IOANNINON
Greece
EU contribution
€ 369 690
Address
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE LIEGE
Belgium
EU contribution
€ 1 087 053,75
Address
Place Du 20 Aout 7
4000 Liege
Activity type
Higher or Secondary Education Establishments
FMF & AID GLOBAL ASSOCIATION
Switzerland
EU contribution
€ 93 750
Address
Schuracherstrasse 25A
8306 Bruttisellen
Activity type
Other
HACETTEPE UNIVERSITESI
Turkey
EU contribution
€ 32 740
Address
Hacettepe Universitesi Beytepe Kampusu Rektorluk Binasi
06800 Cankaya Ankara
Activity type
Higher or Secondary Education Establishments
UNIVERZITETNI KLINICNI CENTER LJUBLJANA
Slovenia
EU contribution
€ 11 250
Address
Zaloska Cesta 002
1000 Ljubljana
Activity type
Higher or Secondary Education Establishments
HOSPITAL SANT JOAN DE DÉU
Spain
EU contribution
€ 44 000
Address
Paseo Sant Joan De Deu 2
08950 Esplugues De Llobregat
Activity type
Research Organisations
OSPEDALE PEDIATRICO BAMBINO GESU
Italy
EU contribution
€ 102 840
Address
Piazza Sant Onofrio 4
00165 Roma
Activity type
Other
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 273 168
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK
France
EU contribution
€ 391 643
Address
5 Rue Watt
75013 Paris
Activity type
Research Organisations
MANDANOVA
France
EU contribution
€ 142 818,64
Address
11 Rue Des Poetes
31320 Castanet-tolosan
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)