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Immunome project consortium for AutoInflammatory Disorders

Immunome project consortium for AutoInflammatory Disorders

Objective

Systemic autoinflammatory diseases (SAID) encompass several rare disorders characterised by extensive clinical and biological inflammation. SAID are caused by the dysregulation of the innate immune system. Due to numerous and unspecific symptoms, tentative diagnosis often leads to failure/delay and inadequate treatments. ImmunAID will deliver a method for rapid and accurate diagnosis across all the spectrum of SAID, in order to improve clinical management of SAID patients. Thanks to parallel analyses run on samples from more than 600 patients with monogenic or undiagnosed SAID collected throughout Europe, Immunaid will generate a unique and comprehensive set of data, based on unbiased multiomics approaches (gene, transcript, protein, microbiome), and hypothesis-driven assays exploring inflammasome, inflammation resolution and immune networks. A centralised data management strategy will enable to conduct integrated analyses for diagnostic biomarker identification. In a discovery phase, semi-supervised clustering of omics data will be combined to supervised analysis of pathway-related data to provide robust classification and strong link to clinical features/impact. The related biomarkers will further be validated externally on independent samples and cohorts. Overall, ImmunAID will disentangle the spectrum of SAID, and propose a new omics- and pathogenesis-based SAID classification associated to a clinical decision making algorithm implementable in daily practice. An efficient dissemination plan will target e.g. guideline-forming bodies, the medical community and patients with the help of the ERN RITA and with the objective of turning our results into clinical practice. To further support this, proactive innovation management will be implemented. To reach its ambitious goals, ImmunAID interdisciplinary consortium gathers high-level partners, including the founder of SAID concept, experts in omics science, immunology, bioinformatics, and involves clinicians and patient advocacy groups.
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Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Address

Rue De Tolbiac 101
75654 Paris

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 3 248 017,29

Participants (23)

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ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

France

EU Contribution

€ 1 027 500

VIB

Belgium

EU Contribution

€ 1 256 880

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 704 966,25

CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE

Belgium

EU Contribution

€ 119 750

KOBENHAVNS UNIVERSITET

Denmark

EU Contribution

€ 342 500

INSTITUT CURIE

France

EU Contribution

€ 392 500

OWKIN FRANCE

France

EU Contribution

€ 383 750

AMBIOTIS

France

EU Contribution

€ 621 250

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany

EU Contribution

€ 570 375

IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON

Greece

EU Contribution

€ 796 250

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 2 600 620

UNIVERSITE DE GENEVE

Switzerland

EU Contribution

€ 275 250

UNIVERSITY OF LEEDS

United Kingdom

EU Contribution

€ 1 012 278,46

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 46 950

PANEPISTIMIO IOANNINON

Greece

EU Contribution

€ 369 690

UNIVERSITE DE LIEGE

Belgium

EU Contribution

€ 1 061 666,25

FMF & AID GLOBAL ASSOCIATION

Switzerland

EU Contribution

€ 93 750

HACETTEPE UNIVERSITESI

Turkey

EU Contribution

€ 32 740

UNIVERZITETNI KLINICNI CENTER LJUBLJANA

Slovenia

EU Contribution

€ 11 250

HOSPITAL SANT JOAN DE DÉU

Spain

EU Contribution

€ 44 000

OSPEDALE PEDIATRICO BAMBINO GESU

Italy

EU Contribution

€ 107 625

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU Contribution

€ 273 168

ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK

France

EU Contribution

€ 443 125

Project information

Grant agreement ID: 779295

Status

Ongoing project

  • Start date

    1 May 2018

  • End date

    30 April 2023

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 15 835 851,25

  • EU contribution

    € 15 835 851,25

Coordinated by:

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France