Objective
Systemic autoinflammatory diseases (SAID) encompass several rare disorders characterised by extensive clinical and biological inflammation. SAID are caused by the dysregulation of the innate immune system. Due to numerous and unspecific symptoms, tentative diagnosis often leads to failure/delay and inadequate treatments. ImmunAID will deliver a method for rapid and accurate diagnosis across all the spectrum of SAID, in order to improve clinical management of SAID patients. Thanks to parallel analyses run on samples from more than 600 patients with monogenic or undiagnosed SAID collected throughout Europe, Immunaid will generate a unique and comprehensive set of data, based on unbiased multiomics approaches (gene, transcript, protein, microbiome), and hypothesis-driven assays exploring inflammasome, inflammation resolution and immune networks. A centralised data management strategy will enable to conduct integrated analyses for diagnostic biomarker identification. In a discovery phase, semi-supervised clustering of omics data will be combined to supervised analysis of pathway-related data to provide robust classification and strong link to clinical features/impact. The related biomarkers will further be validated externally on independent samples and cohorts. Overall, ImmunAID will disentangle the spectrum of SAID, and propose a new omics- and pathogenesis-based SAID classification associated to a clinical decision making algorithm implementable in daily practice. An efficient dissemination plan will target e.g. guideline-forming bodies, the medical community and patients with the help of the ERN RITA and with the objective of turning our results into clinical practice. To further support this, proactive innovation management will be implemented. To reach its ambitious goals, ImmunAID interdisciplinary consortium gathers high-level partners, including the founder of SAID concept, experts in omics science, immunology, bioinformatics, and involves clinicians and patient advocacy groups.
Field of science
- /social sciences/economics and business/business and management/innovation management
- /medical and health sciences/basic medicine/immunology
Call for proposal
H2020-SC1-2017-Single-Stage-RTD
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Funding Scheme
RIA - Research and Innovation actionCoordinator
75654 Paris
France
Participants (24)
75000 Paris
9052 Zwijnaarde - Gent
3000 Leuven
4000 Liege
1165 Kobenhavn
75231 Paris
75010 Paris
31400 Toulouse
48149 Muenster
115 27 Athina
3015 GD Rotterdam
1211 Geneve
LS2 9JT Leeds
WC1E 6BT London
45110 Ioannina
4000 Liege
8306 Bruttisellen
06800 Cankaya Ankara
1000 Ljubljana
08950 Esplugues De Llobregat
00165 Roma
75015 Paris 15
75013 Paris
31320 Castanet-tolosan
