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Immunome project consortium for AutoInflammatory Disorders

Objective

Systemic autoinflammatory diseases (SAID) encompass several rare disorders characterised by extensive clinical and biological inflammation. SAID are caused by the dysregulation of the innate immune system. Due to numerous and unspecific symptoms, tentative diagnosis often leads to failure/delay and inadequate treatments. ImmunAID will deliver a method for rapid and accurate diagnosis across all the spectrum of SAID, in order to improve clinical management of SAID patients. Thanks to parallel analyses run on samples from more than 600 patients with monogenic or undiagnosed SAID collected throughout Europe, Immunaid will generate a unique and comprehensive set of data, based on unbiased multiomics approaches (gene, transcript, protein, microbiome), and hypothesis-driven assays exploring inflammasome, inflammation resolution and immune networks. A centralised data management strategy will enable to conduct integrated analyses for diagnostic biomarker identification. In a discovery phase, semi-supervised clustering of omics data will be combined to supervised analysis of pathway-related data to provide robust classification and strong link to clinical features/impact. The related biomarkers will further be validated externally on independent samples and cohorts. Overall, ImmunAID will disentangle the spectrum of SAID, and propose a new omics- and pathogenesis-based SAID classification associated to a clinical decision making algorithm implementable in daily practice. An efficient dissemination plan will target e.g. guideline-forming bodies, the medical community and patients with the help of the ERN RITA and with the objective of turning our results into clinical practice. To further support this, proactive innovation management will be implemented. To reach its ambitious goals, ImmunAID interdisciplinary consortium gathers high-level partners, including the founder of SAID concept, experts in omics science, immunology, bioinformatics, and involves clinicians and patient advocacy groups.

Call for proposal

H2020-SC1-2016-2017

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Sub call

H2020-SC1-2017-Single-Stage-RTD

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Net EU contribution
€ 3 189 482,10
Address
Rue De Tolbiac 101
75654 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 3 189 482,10

Participants (26)

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
Net EU contribution
€ 897 997,50
Address
3 Avenue Victoria
75000 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 897 997,50
VIB VZW
Belgium
Net EU contribution
€ 1 256 880,00
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Research Organisations
Other funding
€ 1 256 880,00
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Net EU contribution
€ 704 966,25
Address
Oude Markt 13
3000 Leuven

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Higher or Secondary Education Establishments
Other funding
€ 704 966,25
CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE
Belgium
Net EU contribution
€ 151 000,00
Address
Avenue De L Hopital 1
4000 Liege

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Region
Région wallonne Prov. Liège Arr. Liège
Activity type
Research Organisations
Other funding
€ 151 000,00
KOBENHAVNS UNIVERSITET
Denmark
Net EU contribution
€ 342 500,00
Address
Norregade 10
1165 Kobenhavn

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Region
Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Other funding
€ 342 500,00
INSTITUT CURIE
France
Net EU contribution
€ 392 500,00
Address
Rue D'ulm 26
75231 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 392 500,00
OWKIN FRANCE
France
Net EU contribution
€ 383 750,00
Address
12 Rue Martel
75010 Paris

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 383 750,00
AMBIOTIS
France
Net EU contribution
€ 621 250,00
Address
Canal Biotech 2 3 Rue Des Satellites
31400 Toulouse

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Occitanie Midi-Pyrénées Haute-Garonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 621 250,00
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Germany
Net EU contribution
€ 632 850,00
Address
Schlossplatz 2
48149 Muenster

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Region
Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 632 850,00
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece
Net EU contribution
€ 796 250,00
Address
Soranou Efesiou 4
115 27 Athina

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Region
Κεντρικός Τομέας Αθηνών Aττική Αττική
Activity type
Research Organisations
Other funding
€ 796 250,00
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 2 568 028,55
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 568 028,55
UNIVERSITE DE GENEVE
Switzerland
Net EU contribution
€ 321 465,00
Address
Rue Du General Dufour 24
1211 Geneve

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Region
Schweiz/Suisse/Svizzera Région lémanique Genève
Activity type
Higher or Secondary Education Establishments
Other funding
€ 321 465,00
UNIVERSITY OF LEEDS
United Kingdom
Net EU contribution
€ 981 028,46
Address
Woodhouse Lane
LS2 9JT Leeds

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Region
Yorkshire and the Humber West Yorkshire Leeds
Activity type
Higher or Secondary Education Establishments
Other funding
€ 981 028,46
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

THE LEEDS TEACHING HOSPITALS NATIONAL HEALTH SERVICE TRUST
United Kingdom
Net EU contribution
€ 11 200,00
Address
St James's University Hospital, Beckett Street
LS9 7TF Leeds

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Region
Yorkshire and the Humber West Yorkshire Leeds
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 11 200,00
UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 35 750,00
Address
Gower Street
WC1E 6BT London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Other funding
€ 35 750,00
PANEPISTIMIO IOANNINON
Greece
Net EU contribution
€ 369 690,00
Address
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina

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Region
Ιωάννινα Ήπειρος Βόρεια Ελλάδα
Activity type
Higher or Secondary Education Establishments
Other funding
€ 369 690,00
UNIVERSITE DE LIEGE
Belgium
Net EU contribution
€ 1 087 053,75
Address
Place Du 20 Aout 7
4000 Liege

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Region
Région wallonne Prov. Liège Arr. Liège
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 087 053,75
FMF & AID GLOBAL ASSOCIATION
Switzerland
Net EU contribution
€ 93 750,00
Address
Schuracherstrasse 25a
8306 Bruttisellen

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Other
Other funding
€ 93 750,00
HACETTEPE UNIVERSITESI
Türkiye
Net EU contribution
€ 32 740,00
Address
Hacettepe Universitesi Beytepe Kampusu Rektorluk Binasi
06800 Cankaya Ankara

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Region
Batı Anadolu Ankara Ankara
Activity type
Higher or Secondary Education Establishments
Other funding
€ 32 740,00
UNIVERZITETNI KLINICNI CENTER LJUBLJANA
Slovenia
Net EU contribution
€ 11 250,00
Address
Zaloska Cesta 002
1000 Ljubljana

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Region
Slovenija Zahodna Slovenija Osrednjeslovenska
Activity type
Higher or Secondary Education Establishments
Other funding
€ 11 250,00
HOSPITAL SANT JOAN DE DEU
Spain
Net EU contribution
€ 44 000,00
Address
Paseo Sant Joan De Deu 2
08950 Esplugues De Llobregat

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 44 000,00
OSPEDALE PEDIATRICO BAMBINO GESU
Italy
Net EU contribution
€ 102 840,00
Address
Piazza Sant Onofrio 4
00165 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Other funding
€ 102 840,00
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
Net EU contribution
€ 273 168,00
Address
Rue Leblanc 25
75015 Paris 15

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 273 168,00
ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK
France
Net EU contribution
€ 353 043,00
Address
5 Rue Watt
75013 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 353 043,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

LUXEMBOURG INSTITUTE OF HEALTH
Luxembourg
Net EU contribution
€ 38 600,00
Address
1a Rue Rue Thomas Edison
1445 Strassen

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Region
Luxembourg Luxembourg Luxembourg
Activity type
Research Organisations
Other funding
€ 38 600,00
MANDANOVA
France
Net EU contribution
€ 142 818,64
Address
11 Rue Des Poetes
31320 Castanet-tolosan

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Occitanie Midi-Pyrénées Haute-Garonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 142 818,64