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Immunome project consortium for AutoInflammatory Disorders

Objectif

Systemic autoinflammatory diseases (SAID) encompass several rare disorders characterised by extensive clinical and biological inflammation. SAID are caused by the dysregulation of the innate immune system. Due to numerous and unspecific symptoms, tentative diagnosis often leads to failure/delay and inadequate treatments. ImmunAID will deliver a method for rapid and accurate diagnosis across all the spectrum of SAID, in order to improve clinical management of SAID patients. Thanks to parallel analyses run on samples from more than 600 patients with monogenic or undiagnosed SAID collected throughout Europe, Immunaid will generate a unique and comprehensive set of data, based on unbiased multiomics approaches (gene, transcript, protein, microbiome), and hypothesis-driven assays exploring inflammasome, inflammation resolution and immune networks. A centralised data management strategy will enable to conduct integrated analyses for diagnostic biomarker identification. In a discovery phase, semi-supervised clustering of omics data will be combined to supervised analysis of pathway-related data to provide robust classification and strong link to clinical features/impact. The related biomarkers will further be validated externally on independent samples and cohorts. Overall, ImmunAID will disentangle the spectrum of SAID, and propose a new omics- and pathogenesis-based SAID classification associated to a clinical decision making algorithm implementable in daily practice. An efficient dissemination plan will target e.g. guideline-forming bodies, the medical community and patients with the help of the ERN RITA and with the objective of turning our results into clinical practice. To further support this, proactive innovation management will be implemented. To reach its ambitious goals, ImmunAID interdisciplinary consortium gathers high-level partners, including the founder of SAID concept, experts in omics science, immunology, bioinformatics, and involves clinicians and patient advocacy groups.

Appel à propositions

H2020-SC1-2017-Single-Stage-RTD
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Coordinateur

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Adresse
Rue De Tolbiac 101
75654 Paris
France
Type d’activité
Research Organisations
Contribution de l’UE
€ 3 189 482,10

Participants (24)

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
Contribution de l’UE
€ 897 997,50
Adresse
3 Avenue Victoria
75000 Paris
Type d’activité
Research Organisations
VIB VZW
Belgique
Contribution de l’UE
€ 1 256 880
Adresse
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Type d’activité
Research Organisations
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgique
Contribution de l’UE
€ 704 966,25
Adresse
Oude Markt 13
3000 Leuven
Type d’activité
Higher or Secondary Education Establishments
CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE
Belgique
Contribution de l’UE
€ 151 000
Adresse
Avenue De L Hopital 1
4000 Liege
Type d’activité
Research Organisations
KOBENHAVNS UNIVERSITET
Danemark
Contribution de l’UE
€ 342 500
Adresse
Norregade 10
1165 Kobenhavn
Type d’activité
Higher or Secondary Education Establishments
INSTITUT CURIE
France
Contribution de l’UE
€ 392 500
Adresse
Rue D'ulm 26
75231 Paris
Type d’activité
Research Organisations
OWKIN FRANCE
France
Contribution de l’UE
€ 383 750
Adresse
12 Rue Martel
75010 Paris
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AMBIOTIS
France
Contribution de l’UE
€ 621 250
Adresse
Canal Biotech 2 3 Rue Des Satellites
31400 Toulouse
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Allemagne
Contribution de l’UE
€ 632 850
Adresse
Schlossplatz 2
48149 Muenster
Type d’activité
Higher or Secondary Education Establishments
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece
Contribution de l’UE
€ 796 250
Adresse
Soranou Efesiou 4
115 27 Athina
Type d’activité
Research Organisations
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Pays-Bas
Contribution de l’UE
€ 2 568 028,55
Adresse
Dr Molewaterplein 40
3015 GD Rotterdam
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITE DE GENEVE
Suisse
Contribution de l’UE
€ 321 465
Adresse
Rue Du General Dufour 24
1211 Geneve
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITY OF LEEDS
United Kingdom
Contribution de l’UE
€ 992 228,46
Adresse
Woodhouse Lane
LS2 9JT Leeds
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE LONDON
United Kingdom
Contribution de l’UE
€ 35 750
Adresse
Gower Street
WC1E 6BT London
Type d’activité
Higher or Secondary Education Establishments
PANEPISTIMIO IOANNINON
Greece
Contribution de l’UE
€ 369 690
Adresse
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina
Type d’activité
Higher or Secondary Education Establishments
UNIVERSITE DE LIEGE
Belgique
Contribution de l’UE
€ 1 087 053,75
Adresse
Place Du 20 Aout 7
4000 Liege
Type d’activité
Higher or Secondary Education Establishments
FMF & AID GLOBAL ASSOCIATION
Suisse
Contribution de l’UE
€ 93 750
Adresse
Schuracherstrasse 25A
8306 Bruttisellen
Type d’activité
Other
HACETTEPE UNIVERSITESI
Turquie
Contribution de l’UE
€ 32 740
Adresse
Hacettepe Universitesi Beytepe Kampusu Rektorluk Binasi
06800 Cankaya Ankara
Type d’activité
Higher or Secondary Education Establishments
UNIVERZITETNI KLINICNI CENTER LJUBLJANA
Slovénie
Contribution de l’UE
€ 11 250
Adresse
Zaloska Cesta 002
1000 Ljubljana
Type d’activité
Higher or Secondary Education Establishments
HOSPITAL SANT JOAN DE DÉU
Espagne
Contribution de l’UE
€ 44 000
Adresse
Paseo Sant Joan De Deu 2
08950 Esplugues De Llobregat
Type d’activité
Research Organisations
OSPEDALE PEDIATRICO BAMBINO GESU
Italie
Contribution de l’UE
€ 102 840
Adresse
Piazza Sant Onofrio 4
00165 Roma
Type d’activité
Research Organisations
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
Contribution de l’UE
€ 273 168
Adresse
Rue Leblanc 25
75015 Paris 15
Type d’activité
Research Organisations
ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK
France
Contribution de l’UE
€ 391 643
Adresse
5 Rue Watt
75013 Paris
Type d’activité
Research Organisations
MANDANOVA
France
Contribution de l’UE
€ 142 818,64
Adresse
11 Rue Des Poetes
31320 Castanet-tolosan
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)