CORDIS
Résultats de la recherche de l’UE

CORDIS

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Immunome project consortium for AutoInflammatory Disorders

Immunome project consortium for AutoInflammatory Disorders

Objectif

Systemic autoinflammatory diseases (SAID) encompass several rare disorders characterised by extensive clinical and biological inflammation. SAID are caused by the dysregulation of the innate immune system. Due to numerous and unspecific symptoms, tentative diagnosis often leads to failure/delay and inadequate treatments. ImmunAID will deliver a method for rapid and accurate diagnosis across all the spectrum of SAID, in order to improve clinical management of SAID patients. Thanks to parallel analyses run on samples from more than 600 patients with monogenic or undiagnosed SAID collected throughout Europe, Immunaid will generate a unique and comprehensive set of data, based on unbiased multiomics approaches (gene, transcript, protein, microbiome), and hypothesis-driven assays exploring inflammasome, inflammation resolution and immune networks. A centralised data management strategy will enable to conduct integrated analyses for diagnostic biomarker identification. In a discovery phase, semi-supervised clustering of omics data will be combined to supervised analysis of pathway-related data to provide robust classification and strong link to clinical features/impact. The related biomarkers will further be validated externally on independent samples and cohorts. Overall, ImmunAID will disentangle the spectrum of SAID, and propose a new omics- and pathogenesis-based SAID classification associated to a clinical decision making algorithm implementable in daily practice. An efficient dissemination plan will target e.g. guideline-forming bodies, the medical community and patients with the help of the ERN RITA and with the objective of turning our results into clinical practice. To further support this, proactive innovation management will be implemented. To reach its ambitious goals, ImmunAID interdisciplinary consortium gathers high-level partners, including the founder of SAID concept, experts in omics science, immunology, bioinformatics, and involves clinicians and patient advocacy groups.
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Coordinateur

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Adresse

Rue De Tolbiac 101
75654 Paris

France

Type d’activité

Higher or Secondary Education Establishments

Contribution de l’UE

€ 3 248 017,29

Participants (23)

Trier par ordre alphabétique

Trier par contribution de l’UE

Tout développer

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

France

Contribution de l’UE

€ 1 027 500

VIB

Belgique

Contribution de l’UE

€ 1 256 880

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgique

Contribution de l’UE

€ 704 966,25

CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE

Belgique

Contribution de l’UE

€ 119 750

KOBENHAVNS UNIVERSITET

Danemark

Contribution de l’UE

€ 342 500

INSTITUT CURIE

France

Contribution de l’UE

€ 392 500

OWKIN FRANCE

France

Contribution de l’UE

€ 383 750

AMBIOTIS

France

Contribution de l’UE

€ 621 250

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Allemagne

Contribution de l’UE

€ 570 375

IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON

Grèce

Contribution de l’UE

€ 796 250

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Pays-Bas

Contribution de l’UE

€ 2 600 620

UNIVERSITE DE GENEVE

Suisse

Contribution de l’UE

€ 275 250

UNIVERSITY OF LEEDS

Royaume-Uni

Contribution de l’UE

€ 1 012 278,46

UNIVERSITY COLLEGE LONDON

Royaume-Uni

Contribution de l’UE

€ 46 950

PANEPISTIMIO IOANNINON

Grèce

Contribution de l’UE

€ 369 690

UNIVERSITE DE LIEGE

Belgique

Contribution de l’UE

€ 1 061 666,25

FMF & AID GLOBAL ASSOCIATION

Suisse

Contribution de l’UE

€ 93 750

HACETTEPE UNIVERSITESI

Turquie

Contribution de l’UE

€ 32 740

UNIVERZITETNI KLINICNI CENTER LJUBLJANA

Slovénie

Contribution de l’UE

€ 11 250

HOSPITAL SANT JOAN DE DÉU

Espagne

Contribution de l’UE

€ 44 000

OSPEDALE PEDIATRICO BAMBINO GESU

Italie

Contribution de l’UE

€ 107 625

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

Contribution de l’UE

€ 273 168

ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK

France

Contribution de l’UE

€ 443 125

Informations projet

N° de convention de subvention: 779295

État

Projet en cours

  • Date de début

    1 Mai 2018

  • Date de fin

    30 Avril 2023

Financé au titre de:

H2020-EU.3.1.1.

  • Budget total:

    € 15 835 851,25

  • Contribution de l’UE

    € 15 835 851,25

Coordonné par:

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France