CORDIS
EU research results

CORDIS

English EN
Photochemical cascade reactions by merging organo- and iridium catalysis: A stereocontrolled entry to molecular complexity.

Photochemical cascade reactions by merging organo- and iridium catalysis: A stereocontrolled entry to molecular complexity.

Objective

The requirement for drug discovery to facilitate the identification of successful lead candidates has challenged synthetic chemists to develop innovative strategies to rapidly generate screening collections of chiral molecules. Recently, the application of asymmetric aminocatalysis to cascade reactions has addressed this target enabling extraordinary levels of sophistication and stereocontrol, while fulfilling the requirements for both atom and step economy. Because of the rapid progress achieved, the general perception is that it would be difficult to further expand the synthetic potential of the aminocatalytic cascade approach. However, recent works from the host´s laboratories demonstrate that, by exploiting the photochemical activity of organocatalytic intermediates, light irradiation unlocks reaction pathways unavailable in the ground-state domain. In particular, by bringing a catalytically generated iminium ion to an electronically excited state, it is possible to perform β-functionalisations of enals not achievable under thermal control.
This proposal seeks to capitalise upon this novel reactivity to further expand the synthetic potential of the organocatalytic cascade technique, by providing new opportunities for reaction invention. We plan to accomplish this by exploiting the photochemistry of iminium ions in processes that synergistically combine enamine chemistry with transition metal catalysis, thus merging, for the first time, tandem organo-metal catalysis with asymmetric photoreactions. The planned research combines perfectly the host´s expertise in photochemical organocatalysis with the fellow´s experience in transition metal catalysis. These enantioselective cascade reactions will be used for the synthesis of chiral molecules of biological interest. The libraries generated will serve as a platform for the design and development of potential drug candidates. The biological evaluation will be undertaken in collaboration with an international recognized
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA

Address

Avenida Paissos Catalans 16
43007 Tarragona

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 158 121,60

Project information

Grant agreement ID: 795793

Status

Ongoing project

  • Start date

    1 April 2018

  • End date

    31 March 2020

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 158 121,60

  • EU contribution

    € 158 121,60

Coordinated by:

FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA

Spain