Periodic Reporting for period 1 - PHOTO-FLUOR (Enantioselective Carbon-Fluorine Bond Formation: A Molecular Editing Approach toward Drug Discovery)
Reporting period: 2018-05-09 to 2020-05-08
The candidate worked also on the β–fluorination of saturated aldehyde through the enamine-mediated pathway. After screening different reaction conditions (solvents, temperature, Lewis acids, different light sources, and external photocatalysts), only decomposition of the starting aldehyde was observed in most of the cases.
As it was not possible to proceed with the initial idea (WP1), a new strategy has been set in motion. It merges the experience of the host (Prof. Melchiorre) in enantioselective photochemical C-C bond formation reactions and the one of Dr. Raha Roy in transition metal catalysis: the photoinduced nickel-catalyzed enantioselective C-C bond formation reaction to obtain enantioenriched carbonyl compounds. As demonstrated in the Periodic Technical Report the initial results are very promising.