CORDIS
EU research results

CORDIS

English EN
Simulating the dynamics of viral evolution: A computer-aided study toward engineering effective vaccines

Simulating the dynamics of viral evolution: A computer-aided study toward engineering effective vaccines

Objective

The adaptive immune system mounts pathogen-specific responses against diverse microbes and establishes memory of past infections thus constituting the basis of vaccination. Although major advances have been made in understanding pertinent molecular and cellular phenomena, an understanding of the mechanistic principles that govern the emergence of an immune response has proven so far to be elusive. An example of a consequence of this missing knowledge is the inability to design a vaccine against HIV. The difficulty in elucidating the mechanistic principles underlying adaptive immune responses are due to the fact that the pertinent processes involve cooperative dynamic events with many participating components that must act collectively for a given phenomenon to emerge. Many groups around the world work on designing vaccines by trying to stimulate good antibodies that will neutralize the virus. In this project we propose an alternative strategy: by means of harnessing the cellular immune response, or the T cell immune response, which controls virus infected cells and controls infections in the body; this strategy might not prevent infection but it can certainly prevent disease. For this, computer-aided approaches will offer the possibility of defining fitness of highly mutable pathogens (and cancers) so that to facilitate rational design of vaccines and therapies. The proposed computer modeling of viral dynamics, can offer an unprecedented means to identify vulnerable regions of the virus through the application of statistical mechanics-based computer simulation of the evolution dynamics of escape mutants in HIV, guiding this way the engineering of efficacious vaccine immunogens for diverse viruses.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

NATIONAL TECHNICAL UNIVERSITY OF ATHENS - NTUA

Address

Heroon Polytechniou 9 Zographou Campus
15780 Athina

Greece

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 236 457

Partners (1)

Sort alphabetically

Expand all

MASSACHUSSETTS INSTITUTE OF TECHNOLOGY MIT CORPORATION

Project information

Grant agreement ID: 796794

Status

Ongoing project

  • Start date

    1 November 2018

  • End date

    31 October 2021

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 236 457

  • EU contribution

    € 236 457

Coordinated by:

NATIONAL TECHNICAL UNIVERSITY OF ATHENS - NTUA

Greece