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Functional Analysis of Schizophrenia Risk Gene RBM12

Objective

Schizophrenia is a devastating disease with high societal costs. However, little is known about the biological mechanisms behind the disorder, a knowledge gap that has stalled the development of new treatments. We recently discovered that truncating mutations in RBM12, an RNA binding protein, are associated with schizophrenia. This finding provides a novel entry point to understanding the disease, but fully exploiting the discovery requires further examination of the function of RBM12. Here I propose to begin that effort by using the zebrafish model system to first, determine the role of RBM12 in brain development; second, discover the role of RBM12 in brain function as assessed by functional connectivity and behavioural assays; and third, identify RBM12’s direct and indirect targets using RNA-seq and iCLIP (individual-nucleotide resolution cross-linking and immunoprecipitation). These studies will aid in illuminating the biological basis of schizophrenia and, ultimately, lead to novel treatments.
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Coordinator

UNIVERSITY COLLEGE LONDON

Address

Gower Street
Wc1e 6bt London

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 269 857,80

Partners (1)

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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Project information

Grant agreement ID: 798076

Status

Ongoing project

  • Start date

    1 September 2018

  • End date

    31 August 2021

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 269 857,80

  • EU contribution

    € 269 857,80

Coordinated by:

UNIVERSITY COLLEGE LONDON

United Kingdom