CORDIS
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Structural Openings to Understand and Prevent Tick Borne Encephalitis

Structural Openings to Understand and Prevent Tick Borne Encephalitis

Objective

Tick-borne encephalitis virus (TBEV) is emerging in Europe. It causes tick-borne encephalitis (TBE), a disease with a high mortality rate and even higher rates of life-long neurological effects in individuals that contract infections. As environmental and societal changes promote viral spread and current vaccine use is limited, it is not surprising that TBE incidence is on the rise. With uncertain diagnostics and no medications on the market, the threat to European health care becomes significant, making development of control measures a high priority.

Efforts to develop treatments and improve detection are largely hampered by a lack of structural knowledge about TBEV. Here we seek to fill the critical information gap, using electron cryo-microscopy, which has become a powerful technology for revealing atomic-level details about viruses. We will harness unique expertise in the fields of virology and structural biology to answer fundamental questions about virus structure, assembly, morphogenesis, and function. Explicit new knowledge regarding TBEV will push forward European excellence in virus research producing impactful results for their exploitation in drug discovery and diagnostic developments.
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Coordinator

HELSINGIN YLIOPISTO

Address

Yliopistonkatu 3
00014 Helsingin Yliopisto

Finland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 179 325,60

Project information

Grant agreement ID: 799929

Status

Ongoing project

  • Start date

    18 May 2018

  • End date

    17 May 2020

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 179 325,60

  • EU contribution

    € 179 325,60

Coordinated by:

HELSINGIN YLIOPISTO

Finland