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Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment

Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment

Objective

Nanotechnology promises significant scientific, economic and societal benefits, but commercialization and growth are threatened by safety uncertainties. Classical hazard testing strategies to define the human and environmental health impact of engineered nanomaterials (ENM) commonly apply unrealistic acute, high-doses to models that do not reflect the in vivo environment. Furthermore, existing in vitro and in silico hazard detection methods are not accurately predictive. PATROLS addresses these limitations by establishing and standardizing the next generation of advanced safety assessment tools for improved prediction of the adverse effects caused by chronic ENM exposure in human and environmental systems. PATROLS will deliver: 1) physiologically representative multi-cellular in vitro 3D lung, gastrointestinal tract and liver models; 2) cross-species models integrating human and environmental safety testing; 3) innovative ecotoxicity bioassays in several organisms across a food chain; 4) robust in silico models for dosimetry, interspecies toxicity extrapolation and hazard prediction. ENM characterization under physiologically relevant experimental conditions will be integral to this realistic, exposure driven strategy. A systems biology approach will also be adopted to identify key events linked to adverse outcome pathways, informing mechanism-based endpoints associated with real-life ENM exposures. These objectives will be achieved by an international network of world-leading academic, governmental, industrial, SME, risk assessment agency and NGO partners. The innovative in vitro and in silico nanosafety testing tools developed by PATROLS will balance speed, cost and biological complexity, while reducing uncertainty via improved predictive power. The smart targeted testing approach will drive a paradigm shift in (eco)toxicology towards mechanism-based ENM hazard assessment to support policy development in human and environmental nanosafety regulatory frameworks.
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Coordinator

SWANSEA UNIVERSITY

Address

Singleton Park
Sa2 8pp Swansea

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 436 623,75

Participants (24)

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THE UNIVERSITY OF EXETER

United Kingdom

EU Contribution

€ 590 886,25

UNIVERSITE DE FRIBOURG

Switzerland

EU Contribution

€ 863 390

HERIOT-WATT UNIVERSITY

United Kingdom

EU Contribution

€ 1 166 363,75

UNIVERSITEIT LEIDEN

Netherlands

EU Contribution

€ 850 467,50

UNIVERSITA DI PISA

Italy

EU Contribution

€ 384 930

UNIVERSITE CATHOLIQUE DE LOUVAIN

Belgium

EU Contribution

€ 428 826,25

UNIVERSITE DE NAMUR ASBL

Belgium

EU Contribution

€ 538 712,50

DANMARKS TEKNISKE UNIVERSITET

Denmark

EU Contribution

€ 584 987,50

QSAR LAB SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA

Poland

EU Contribution

€ 353 193,75

HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC.

United States

UNIVERSITY OF SOUTH CAROLINA

United States

DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO

Denmark

EU Contribution

€ 944 616,25

RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU

Netherlands

EU Contribution

€ 931 765

EUROPEAN RESEARCH SERVICES GMBH

Germany

EU Contribution

€ 311 250

UNITED KINGDOM RESEARCH AND INNOVATION

United Kingdom

EU Contribution

€ 88 656,25

MEDICAL RESEARCH COUNCIL

United Kingdom

KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

South Korea

INSTITUTE OF OCCUPATIONAL MEDICINE

United Kingdom

EU Contribution

€ 370 816,25

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 441 845

INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG AN DER HEINRICH-HEINE-UNIVERSITAT DUSSELDORF GMBH

Germany

EU Contribution

€ 597 252,50

BASF SE

Germany

EU Contribution

€ 759 842,50

INSPHERO AG

Switzerland

EU Contribution

€ 481 961,25

MISVIK BIOLOGY OY

Finland

EU Contribution

€ 336 325

NANOTECHNOLOGY INDUSTRIES ASSOCIATION

Belgium

EU Contribution

€ 251 468,75

Project information

Grant agreement ID: 760813

Status

Ongoing project

  • Start date

    1 January 2018

  • End date

    30 June 2021

Funded under:

H2020-EU.2.1.2.2.

  • Overall budget:

    € 13 108 347,50

  • EU contribution

    € 12 714 180

Coordinated by:

SWANSEA UNIVERSITY

United Kingdom