The integration of mechanical and chemical signals in neuronal guidance

Project Information

MECHEMGUI

Grant agreement ID: 772426

DOI 10.3030/772426

Project closed

EC signature date 15 May 2018

Start date 1 June 2018

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 468 520,00

EU contribution € 2 468 520,00

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (22)

Mechanics in the nervous system: From development to disease

Author(s): Eva K. Pillai, Kristian Franze
Published in: Neuron, 2024, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2023.10.005

Regenerative capacity of neural tissue scales with changes in tissue mechanics post injury

Author(s): Alejandro Carnicer-Lombarte, Damiano G. Barone, Filip Wronowski, George G. Malliaras, James W. Fawcett, Kristian Franze
Published in: Biomaterials, 2023, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2023.122393

Theory for Durotactic Axon Guidance

Author(s): Hadrien Oliveri, Kristian Franze, Alain Goriely
Published in: Physical Review Letters, Issue 126/11, 2021, Page(s) 118101-1 - 118101-6, ISSN 0031-9007
Publisher: American Physical Society
DOI: 10.1103/physrevlett.126.118101

Cortical cell stiffness is independent of substrate mechanics

Author(s): Johannes Rheinlaender, Andrea Dimitracopoulos, Bernhard Wallmeyer, Nils M. Kronenberg, Kevin J. Chalut, Malte C. Gather, Timo Betz, Guillaume Charras, Kristian Franze
Published in: Nature Materials, Issue 19/9, 2020, Page(s) 1019-1025, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-020-0684-x

Prevention of the foreign body response to implantable medical devices by inflammasome inhibition

Author(s): Damiano G Barone, Alejandro Carnicer-Lombarte, Panagiotis Tourlomousis, Russell S Hamilton, Malwina Prater, Alexandra L Rutz, Ivan B Dimov, George G Malliaras, Stephanie P Lacour, Avril A B Robertson, Kristian Franze, James W Fawcett, Clare E Bryant
Published in: PNAS, Issue 119(12), 2022, ISSN 1091-6490
Publisher: The National Academy of Sciences
DOI: 10.1073/pnas.2115857119

Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation.

Author(s): Jakobs, Maximilian AH; Zemel, Assaf; Franze, Kristian
Published in: eLife, Issue 2, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications

Axons in the Chick Embryo Follow Soft Pathways Through Developing Somite Segments

Author(s): Julia Schaeffer, Isabell P Weber, Amelia J Thompson, Roger J Keynes, Kristian Franze
Published in: Frontiers in Cell and Developmental Biology, 2022, ISSN 2296-634X
Publisher: Frontiers Media S.A..
DOI: 10.3389/fcell.2022.917589

StemBond hydrogels optimise the mechanical microenvironment for embryonic stem cells

Author(s): Céline Labouesse; Chibeza C. Agley; Bao Xiu Tan; Moritz Hofer; Alex Winkel; Giuliano Giuseppe Stirparo; Hannah T. Stuart; Christophe M. Verstreken; William Mansfield; Paul Bertone; Kristian Franze; José C. R. Silva; Kevin J. Chalut
Published in: Nature Communications, Issue 12(1), 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26236-5

Mutation of the ALS-/FTD-Associated RNA-Binding Protein FUS Affects Axonal Development

Author(s): Francesca W. van Tartwijk, Lucia C. S. Wunderlich, Ioanna Mela, Stanislaw Makarchuk, Maximilian A. H. Jakobs, Seema Qamar, Kristian Franze, Gabriele S. Kaminski Schierle, Peter H. St George-Hyslop, Julie Qiaojin Lin, Christine E. Holt and Clemens F. Kaminski
Published in: Journal of Neuroscience, 2024, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.2148-23.2024

Spatial heterogeneity of cell-matrix adhesive forces predicts human glioblastoma migration

Author(s): Rasha Rezk, Bill Zong Jia, Astrid Wendler, Ivan Dimov, Colin Watts, Athina E Markaki, Kristian Franze, Alexandre J Kabla
Published in: Neuro-Oncology Advances, Issue 2/1, 2020, ISSN 2632-2498
Publisher: Oxford University Press
DOI: 10.1093/noajnl/vdaa081

Effective cell membrane tension is independent of polyacrylamide substrate stiffness

Author(s): Eva Kreysing; Jeffrey Mc Hugh; Sarah K Foster; Kurt Andresen; Ryan D Greenhalgh; Eva K Pillai; Andrea Dimitracopoulos; Ulrich F Keyser; Kristian Franze
Published in: PNAS Nexus, Issue 1, 2023, ISSN 2752-6542
Publisher: Oxford Academic
DOI: 10.1093/pnasnexus/pgac299

Soft Polydimethylsiloxane-Supported Lipid Bilayers for Studying T Cell Interactions

Author(s): Anna H. Lippert, Ivan B. Dimov, Alexander K. Winkel, Jane Humphrey, James McColl, Kevin Y. Chen, Ana M. Santos, Edward Jenkins, Kristian Franze, Simon J. Davis, David Klenerman
Published in: Biophysical Journal, Issue 120/1, 2021, Page(s) 35-45, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2020.11.021

Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis

Author(s): Jacob Kjell, Judith Fischer-Sternjak, Amelia J. Thompson, Christian Friess, Matthew J. Sticco, Favio Salinas, Jürgen Cox, David C. Martinelli, Jovica Ninkovic, Kristian Franze, Herbert B. Schiller, Magdalena Götz
Published in: Cell Stem Cell, Issue 26/2, 2020, Page(s) 277-293.e8, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2020.01.002

Brain tissue mechanics is governed by microscale relations of the tissue constituents

Author(s): P Sáez, C Borau, N Antonovaite, K Franze
Published in: Biomaterials, 2023, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2023.122273

Tensed axons are on fire

Author(s): Kristian Franze
Published in: PNAS, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2321811121

Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain

Author(s): Amelia J Thompson, Eva K Pillai, Ivan B Dimov, Sarah K Foster, Christine E Holt, Kristian Franze
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.39356

KymoButler, a deep learning software for automated kymograph analysis

Author(s): Maximilian AH Jakobs, Andrea Dimitracopoulos, Kristian Franze
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.42288

Niche stiffness underlies the ageing of central nervous system progenitor cells

Author(s): Michael Segel, Björn Neumann, Myfanwy F. E. Hill, Isabell P. Weber, Carlo Viscomi, Chao Zhao, Adam Young, Chibeza C. Agley, Amelia J. Thompson, Ginez A. Gonzalez, Amar Sharma, Staffan Holmqvist, David H. Rowitch, Kristian Franze, Robin J. M. Franklin, Kevin J. Chalut
Published in: Nature, Issue 573/7772, 2019, Page(s) 130-134, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1484-9

Tissue stiffness at the human maternal–fetal interface

Author(s): Yassen Abbas, Alejandro Carnicer-Lombarte, Lucy Gardner, Jake Thomas, Jan J Brosens, Ashley Moffett, Andrew M Sharkey, Kristian Franze, Graham J Burton, Michelle L Oyen
Published in: Human Reproduction, Issue 34/10, 2019, Page(s) 1999-2008, ISSN 0268-1161
Publisher: Oxford University Press
DOI: 10.1093/humrep/dez139

Mechanical Regulation of Neurite Polarization and Growth: A Computational Study

Author(s): Maximilian A.H. Jakobs, Kristian Franze, Assaf Zemel
Published in: Biophysical Journal, Issue 118/8, 2020, Page(s) 1914-1920, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2020.02.031

Cell surface fluctuations regulate early embryonic lineage sorting

Author(s): Ayaka Yanagida 1 , Elena Corujo-Simon 2 , Christopher K Revell 3 , Preeti Sahu 4 , Giuliano G Stirparo 2 , Irene M Aspalter 5 , Alex K Winkel, Ruby Peters 6 , Henry De Belly 7 , Davide A D Cassani 5 , Sarra Achouri 8 , Raphael Blumenfeld 9 , Kristian Franze 6 , Edouard Hannezo 4 , Ewa K Paluch 10 , Jennifer Nichols 11 , Kevin J Chalut 12
Published in: Cell, Issue 185(5), 2022, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.01.022

Integrating Chemistry and Mechanics: The Forces Driving Axon Growth

Author(s): Kristian Franze
Published in: Annual Review of Cell and Developmental Biology, Issue 36/1, 2020, Page(s) 61-83, ISSN 1081-0706
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-cellbio-100818-125157