Skip to main content

In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy

Objective

According to the 2014 European Society of Cardiology Guidelines, cardiomyopathies are defined as structural and functional abnormalities of the ventricular myocardium that are unexplained by flow limiting coronary artery disease or abnormal loading conditions. There are four major classifications of cardiomyopathy: hypertrophic (HCM), dilated (DCM), restrictive (RCM), and arrhythmogenic right ventricular (ARVC).
Familial cardiomyopathies (FCM) are most commonly diagnosed, or progress of the disease is monitored, through in vivo imaging, with either echocardiography or, increasingly, cardiac magnetic resonance imaging (MRI). The treatment of symptoms of FCM by established therapies could only in part improve the outcome, but novel therapies need to be developed to affect the disease process and time course more fundamentally.
SILICOFCM project will develop in silico computational cloud platform which will integrate from stopped-flow molecular kinetic assays to magnetic resonance imaging of the whole heart, bioinformatics and image processing tools with state of the art computer models with the aim to reduce animal and clinical studies for a new drug development and optimized clinical therapy of FCM.
The developed system will be distributed on the cloud platforms in order to achieve efficient data storage and high-performance computing, that can offer end users results in reasonably short time. Academic technical partners IIT, UOI, UL and BSC will be responsible for developing and integration of in silico cloud computational platform with multi-scale cardiac muscle modelling which include experiments on protein mutation in vitro from UNIKENT, UNIFI and UW. Bioinformatics tools will be integrated by US company SBG. Clinical partners UNEW, ICVDV, UPMC and UHREG will do retrospective and prospective studies. SME partner R-Tech will be in charge of regulatory issues and reports and BIOIRC will do the exploitation of the project.

Field of science

  • /medical and health sciences/clinical medicine/radiology/medical imaging/magnetic resonance imaging
  • /natural sciences/biological sciences/genetics and heredity/mutation
  • /medical and health sciences/clinical medicine/cardiology

Call for proposal

H2020-SC1-2017-CNECT-2
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERING BIOIRC DOO
Address
Prvoslava Stojanovica Street 6
34000 Kragujevac
Serbia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 721 750

Participants (14)

ILLINOIS INSTITUTE OF TECHNOLOGY
United States
EU contribution
€ 417 750
Address
10 W. 35Th Street, Suite 7D7-1
60616 Chicago Il
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF KENT
United Kingdom
EU contribution
€ 413 550
Address
The Registry Canterbury
CT2 7NZ Canterbury, Kent
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 604 090
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
EU contribution
€ 475 100
Address
Piazza San Marco 4
50121 Florence
Activity type
Higher or Secondary Education Establishments
INSTITUT ZA KARDIOVASKULARNE BOLESTI VOJVODINE
Serbia
EU contribution
€ 445 750
Address
Put Doktora Goldmana 4
21204 Sremska Kamenica
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SORBONNE UNIVERSITE

Participation ended

France
EU contribution
€ 0
Address
21 Rue De L'ecole De Medecine
75006 Paris
Activity type
Higher or Secondary Education Establishments
KLINIKUM DER UNIVERSITAET REGENSBURG
Germany
EU contribution
€ 374 625
Address
Frans Josef Strauss Allee 11
93053 Regensburg
Activity type
Higher or Secondary Education Establishments
PANEPISTIMIO IOANNINON
Greece
EU contribution
€ 276 375
Address
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina
Activity type
Higher or Secondary Education Establishments
BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION
Spain
EU contribution
€ 342 375
Address
Calle Jordi Girona 31
08034 Barcelona
Activity type
Research Organisations
UNIVERZA V LJUBLJANI
Slovenia
EU contribution
€ 187 500
Address
Kongresni Trg 12
1000 Ljubljana
Activity type
Higher or Secondary Education Establishments
STEINBEIS ADVANCED RISK TECHNOLOGIES GMBH
Germany
EU contribution
€ 278 750
Address
Fangelsbachstrasse 14
70178 Stuttgart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY OF WASHINGTON
United States
EU contribution
€ 450 201,25
Address
Brooklyn Avenue Ne 4333
98195 9472 Seattle Wa
Activity type
Higher or Secondary Education Establishments
SEVEN BRIDGES GENOMICS INC
United States
EU contribution
€ 339 375
Address
1 Main Street 500
02142 Cambridge Ma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FACULTY OF MEDICINE, UNIVERSITY OF BELGRADE
Serbia
EU contribution
€ 180 250
Address
Dr Subotica, 8
11000 Belgrade
Activity type
Higher or Secondary Education Establishments