Functionalized Magnetic Resonance Beacons for Enhanced Spectroscopy and Imaging

Projektinformationen

FunMagResBeacons

ID Finanzhilfevereinbarung: 786707

DOI 10.3030/786707

EK-Unterschriftsdatum 15 Mai 2018

Startdatum 1 Oktober 2018

Enddatum 30 September 2024

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten € 2 762 223,00

EU-Beitrag € 2 762 223,00

Koordiniert durch

UNIVERSITY OF SOUTHAMPTON
United Kingdom

Ziel

"This project will develop and demonstrate molecular agents called functional magnetic resonance beacons (fMRBs). These will provide a new set of versatile spectroscopic tools for the spatially resolved study of chemistry, biochemistry, diffusion, flow and percolation inside opaque objects. The fMRB agents support hyperpolarized nuclear spin order, which generates enormously enhanced nuclear magnetic resonance (NMR) signals. The agents are designed to maintain such order for long times (between 5 minutes and several hours) in ambient temperature solution, enabling their transport deep inside opaque objects. The molecules are functionalized, so that they “light up"" in an NMR or magnetic resonance imaging (MRI) experiment, upon triggering by specific chemical signals or physical conditions (sensory functionality), and may also to bind to selected molecular targets (binding functionality). One set of proposed realisations possesses “lock-and-key” functionality, meaning that the hyperpolarized nuclear spin order is “locked” into a form which is invisible in the NMR spectrometer, but which may be “unlocked” at any chosen time by applying a suitable radiofrequency pulse sequence. The following molecular moieties are proposed as storage modules: (1) molecular cages, such as functionalized C60 fullerenes, encapsulating noble gas atoms such as 3He; (2) spin clusters supporting long-lived states, such as pairs of 13C or 15N nuclei, in shielded molecular environments. The sensory moieties include tailored peptide sequences, which may be activated by the presence of particular proteases, while binding modules include moieties such as biotin. The agents are designed to be conveniently transportable in a hyperpolarized state. Potential long-term applications include in vivo molecular imaging by MRI.
"

Wissenschaftliches Gebiet

• engineering and technology › electrical engineering, electronic engineering, information engineering › information engineering › telecommunications › radio technology › radio frequency
• natural sciences › chemical sciences › inorganic chemistry › noble gases
• natural sciences › biological sciences › biochemistry › biomolecules
• engineering and technology › medical engineering › diagnostic imaging › magnetic resonance imaging
• natural sciences › physical sciences › optics › spectroscopy

Programm/Programme

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Thema/Themen

• ERC-2017-ADG - ERC Advanced Grant

Aufforderung zur Vorschlagseinreichung

ERC-2017-ADG

Finanzierungsplan

ERC-ADG - Advanced Grant

Gastgebende Einrichtung

UNIVERSITY OF SOUTHAMPTON

• Netto-EU-Beitrag: € 2 762 223,00
• Adresse: Highfield ; SO17 1BJ Southampton ; Vereinigtes Königreich
• Region: South East (England) › Hampshire and Isle of Wight › Southampton
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 2 762 223,00

Begünstigte (1)

UNIVERSITY OF SOUTHAMPTON

Vereinigtes Königreich

• Netto-EU-Beitrag: € 2 762 223,00
• Adresse: Highfield ; SO17 1BJ Southampton
• Region: South East (England) › Hampshire and Isle of Wight › Southampton
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 2 762 223,00