Objectif This ERC proposal targets novel synthetic strategies to arrive at functional multi-component systems and materials. They possess architectures of such high complexity that it is hard to imagine access to these systems by self-assembly or self-organization only. We will explore tools required to introduce multi-step non-covalent synthesis. We have taken inspiration from Nature, but more importantly we propose to mimic the impressive progress in the field of covalent organic and polymer synthesis. Three connected approaches are defined: The first section focusses on supramolecular polymers and how their polymerization can be compared to that of traditional covalent polymerization; unprecedented similarities are foreseen. Unexplored areas like controlled co-polymerization and achieving “tacticity” in asymmetrically modified building blocks are proposed, with special attention to kinetics and structure characterization. The second section is aiming at synthesizing a multi-component hydrogel leading to a system that is able to recruit receptors in a dynamic and reversible fashion. This work is proposed to culminate in new insights for preparing an artificial extracellular matrix for stem cell to organoid growth. The latter is proposed using a double supramolecular network. The final section takes inspiration from the recent finding that chirality can control spin-selective chemistry. Novel chiral structures with control over pitch and diameter are proposed by two-step synthetic processes. In a three-step non-covalent synthetic procedure, a space-controlled arrangement of chiral quartets on surfaces is proposed using discrete block co-oligomers. Since molecules only have structures and properties, their functions can only be expressed when they are part of complex molecular systems. Hence, if chemists want to synthesize functions in lifelike materials, they have to introduce new approaches and technologies, a game changer is proposed in this ERC proposal. Champ scientifique natural scienceschemical sciencespolymer sciencesmedical and health sciencesmedical biotechnologycells technologiesstem cells Mots‑clés Stereochemistry supramolecular polymers Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Thème(s) ERC-2017-ADG - ERC Advanced Grant Appel à propositions ERC-2017-ADG Voir d’autres projets de cet appel Régime de financement ERC-ADG - Advanced Grant Institution d’accueil TECHNISCHE UNIVERSITEIT EINDHOVEN Contribution nette de l'UE € 2 499 929,00 Adresse GROENE LOPER 3 5612 AE Eindhoven Pays-Bas Voir sur la carte Région Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 2 499 929,00 Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire TECHNISCHE UNIVERSITEIT EINDHOVEN Pays-Bas Contribution nette de l'UE € 2 499 929,00 Adresse GROENE LOPER 3 5612 AE Eindhoven Voir sur la carte Région Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 2 499 929,00
