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Tracers for targeting nerves in the autonomic nervous system

Tracers for targeting nerves in the autonomic nervous system

Objective

"""As a common disease in western men, prostate cancer is a major driver for the billion-euro robotic surgery and laparoscopic devices markets. In the surgical management of prostate cancer patients, next to the tumor resection accuracy, the surgeon’s ability to preserve the nerve-network and prevent erectile dysfunction and urinary incontinence, is key. As these nerves are not visible by eye, image guided surgery approaches aimed at nerve-sparing demand the clinical availability of nerve-specific fluorescence tracers. Hereby it is expected that the ability to visualize peripheral nerves promotes nerve-sparing opportunities and opens up new commercial-avenues for companies involved in the surgical market. Previously my ILLUMINATING NERVES ERC-StG yielded a sensory-nerve targeted lead-compound that was made suitable for imaging somatic-nerves (MY NERVE ERC-PoC). This tracer, however, does not allow for imaging of the autonomic nerves. For autonomic nerves I have now shown, within the same ERC-StG, that an alternative tracer can be used as an imaging target. The aim of the AUTO NERVE ERC-PoC project is to convert the autonomic-nerve targeted lead-compound into a fluorescence tracer. Systematic fine-tuning of this lead will optimize the structure-activity relation and will improve the chance of future commercialization. Ultimately, the outcome of the three complementary ERC-grants should yield an advancement in clinical care.”"
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Host institution

ACADEMISCH ZIEKENHUIS LEIDEN

Address

Albinusdreef 2
2333 Za Leiden

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 140 000

Beneficiaries (1)

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ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 140 000

Project information

Grant agreement ID: 790079

Status

Ongoing project

  • Start date

    1 September 2018

  • End date

    29 February 2020

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 140 000

  • EU contribution

    € 140 000

Hosted by:

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands