Objectif Developing therapies for pancreatic diseases, such as diabetes and pancreatic cancer, is hampered by a limited access to pancreatic tissue in vivo. Engineering three-dimensional (3D) tissue models, which accurately mimic the native organ, have great potential in biomedical applications, by both providing powerful platforms for studying tissue development and homeostasis and for modeling diseases in pharmaceutical testing. Our research proposal establishes a multi-disciplinary European consortium with the ambitious goal of developing an innovative bioprinting approach for generating pancreatic tissue. Tissues and organs comprise multiple cell types with specific biological functions that must be recapitulated in the printed tissue. We will biomimic developmental processes to fabricate 3D bioprinted pancreatic tissue units that allow sustained cell viability, expansion and functional differentiation ex vivo. Specifically, the aim of this proposal is three-fold: 1. To expand and unify the knowledge of 3D in vivo architecture of the developing pancreas; 2. To develop bioprinting technology for engineering vascularized pancreatic tissue units; and 3. To establish conditions for in vitro differentiation and maturation of the bioprinted pancreatic tissue.This exploratory research in the emerging technological field of bioprinting will pave the way towards new technological possibilities of growing functional tissues and organs in a laboratory. We expect that the knowledge and paradigms generated by our research project will not only drive major technological advances in tissue-engineering and bioprinting, but will also open radically new possibilities in medicine, allowing to study pancreatic diseases ex vivo in fabricated tissue, to develop new drugs, and, possibly to facilitate the replacement of injured or diseased tissue. Champ scientifique medical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicineoncologypancreatic cancermedical and health sciencesbasic medicinephysiologyhomeostasis Mots‑clés Pancreas Bioprinting 3D cell printing ex vivo disease model ex vivo organogenesis developmental biology Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Thème(s) FETOPEN-01-2016-2017 - FET-Open research and innovation actions Appel à propositions H2020-FETOPEN-2016-2017 Voir d’autres projets de cet appel Sous appel H2020-FETOPEN-1-2016-2017 Régime de financement RIA - Research and Innovation action Coordinateur KING'S COLLEGE LONDON Contribution nette de l'UE € 788 865,00 Adresse Strand WC2R 2LS London Royaume-Uni Voir sur la carte Région London Inner London — West Westminster Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 788 865,00 Participants (5) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire TEL AVIV UNIVERSITY Israël Contribution nette de l'UE € 483 750,00 Adresse Ramat aviv 69978 Tel aviv Voir sur la carte Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 483 750,00 DE DUVE INSTITUTE AISBL Belgique Contribution nette de l'UE € 421 250,00 Adresse Avenue hippocrate 75/50 1200 Bruxelles / brussel Voir sur la carte Région Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 421 250,00 EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Suisse Contribution nette de l'UE € 381 250,00 Adresse Raemistrasse 101 8092 Zuerich Voir sur la carte Région Schweiz/Suisse/Svizzera Zürich Zürich Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 381 250,00 TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Israël Contribution nette de l'UE € 572 500,00 Adresse Senate building technion city 32000 Haifa Voir sur la carte Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 572 500,00 POIETIS France Contribution nette de l'UE € 352 385,00 Adresse 27 alle charles darwin 33600 Pessac Voir sur la carte PME L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention. Oui Région Nouvelle-Aquitaine Aquitaine Gironde Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 352 385,00