Obiettivo Developing therapies for pancreatic diseases, such as diabetes and pancreatic cancer, is hampered by a limited access to pancreatic tissue in vivo. Engineering three-dimensional (3D) tissue models, which accurately mimic the native organ, have great potential in biomedical applications, by both providing powerful platforms for studying tissue development and homeostasis and for modeling diseases in pharmaceutical testing. Our research proposal establishes a multi-disciplinary European consortium with the ambitious goal of developing an innovative bioprinting approach for generating pancreatic tissue. Tissues and organs comprise multiple cell types with specific biological functions that must be recapitulated in the printed tissue. We will biomimic developmental processes to fabricate 3D bioprinted pancreatic tissue units that allow sustained cell viability, expansion and functional differentiation ex vivo. Specifically, the aim of this proposal is three-fold: 1. To expand and unify the knowledge of 3D in vivo architecture of the developing pancreas; 2. To develop bioprinting technology for engineering vascularized pancreatic tissue units; and 3. To establish conditions for in vitro differentiation and maturation of the bioprinted pancreatic tissue.This exploratory research in the emerging technological field of bioprinting will pave the way towards new technological possibilities of growing functional tissues and organs in a laboratory. We expect that the knowledge and paradigms generated by our research project will not only drive major technological advances in tissue-engineering and bioprinting, but will also open radically new possibilities in medicine, allowing to study pancreatic diseases ex vivo in fabricated tissue, to develop new drugs, and, possibly to facilitate the replacement of injured or diseased tissue. Campo scientifico medical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicineoncologypancreatic cancermedical and health sciencesbasic medicinephysiologyhomeostasis Parole chiave Pancreas Bioprinting 3D cell printing ex vivo disease model ex vivo organogenesis developmental biology Programma(i) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Argomento(i) FETOPEN-01-2016-2017 - FET-Open research and innovation actions Invito a presentare proposte H2020-FETOPEN-2016-2017 Vedi altri progetti per questo bando Bando secondario H2020-FETOPEN-1-2016-2017 Meccanismo di finanziamento RIA - Research and Innovation action Coordinatore KING'S COLLEGE LONDON Contribution nette de l'UE € 788 865,00 Indirizzo Strand WC2R 2LS London Regno Unito Mostra sulla mappa Regione London Inner London — West Westminster Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 788 865,00 Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto TEL AVIV UNIVERSITY Israele Contribution nette de l'UE € 483 750,00 Indirizzo Ramat aviv 69978 Tel aviv Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 483 750,00 DE DUVE INSTITUTE AISBL Belgio Contribution nette de l'UE € 421 250,00 Indirizzo Avenue hippocrate 75/50 1200 Bruxelles / brussel Mostra sulla mappa Regione Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 421 250,00 EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Svizzera Contribution nette de l'UE € 381 250,00 Indirizzo Raemistrasse 101 8092 Zuerich Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Zürich Zürich Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 381 250,00 TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Israele Contribution nette de l'UE € 572 500,00 Indirizzo Senate building technion city 32000 Haifa Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 572 500,00 POIETIS Francia Contribution nette de l'UE € 352 385,00 Indirizzo 27 alle charles darwin 33600 Pessac Mostra sulla mappa PMI L’organizzazione si è definita una PMI (piccola e media impresa) al momento della firma dell’accordo di sovvenzione. Sì Regione Nouvelle-Aquitaine Aquitaine Gironde Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Collegamenti Contatta l’organizzazione Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 352 385,00