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Non-Invasive Chemistry Imaging in the whole human body

Objective

The NICI project’s ambition is to lay the foundations of a new area of research: the study of human biology using non-invasive chemistry imaging. For this, NICI aims to unite two areas of research: metabolomics and magnetic resonance imaging (MRI). Metabolomics studies body functions through the measurement of metabolites; MRI, is able to provide 3D images of the body. By advancing MRI so that it can detect metabolic biomarkers and by discovering powerful new MRI-visible biomarkers, a non-invasive technology can be developed for dynamically mapping biochemical processes in the whole human body.

Vision: This new non-invasive technology for imaging biochemical processes in the human body will open a new and effective window for understanding human biology, diseases and their treatment.

Breakthroughs: I. Methodology for the discovery of discriminative biomarkers and II. Technological platform for full body biochemical imaging.

Novelty: Enabling a paradigm shift from morphologic imaging to biochemical understanding.

Foundational: Establishing the basis for a new research area, the study of human biochemistry using non-invasive biochemical imaging.

High-risk: i) The exact mechanisms of diseases are largely unknown and ii) Measuring specific metabolites is challenging.

Interdisciplinary: Bringing together physicists, biologists, chemists and clinicians.

The NICI project will develop a new methodology for the in vitro discovery of discriminant biomarkers using co-cultured 3D organoids as models for human organs. In addition, the project will develop a measurement platform, integrated with 7T MRI scanners and associated data acquisition approaches to adapt these MRI scanners into 3D biochemical imaging systems. NICI will validate the dynamic 3D chemical imaging approach and its predictive and prognostic value by researching a stratification strategy for patients with liver metastasis of gastrointestinal cancer. (This is one out of many possible applications.)

Call for proposal

H2020-FETOPEN-2016-2017

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Sub call

H2020-FETOPEN-1-2016-2017

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Net EU contribution
€ 558 431,25
Address
Heidelberglaan 100
3584 CX Utrecht
Netherlands

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (13)

NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Norway
Net EU contribution
€ 100 177,50
Address
Hogskoleringen 1
7491 Trondheim

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Region
Norge Trøndelag Trøndelag
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Net EU contribution
€ 392 995,00
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
Net EU contribution
€ 336 093,75
Address
Meibergdreef 15
1105AZ Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
IMAGO 7 FONDAZIONE DI RICERCA ONLUS
Italy
Net EU contribution
€ 379 687,50
Address
Viale Del Tirreno 331
56128 Calambrone Pisa

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Region
Centro (IT) Toscana Pisa
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITA DI PISA
Italy
Net EU contribution
€ 178 656,25
Address
Lungarno Pacinotti 43/44
56126 Pisa

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Region
Centro (IT) Toscana Pisa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
MR COILS BV

Participation ended

Netherlands
Net EU contribution
€ 160 713,75
Address
Shimminck 18
5301 KR Zaltbommel

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Oost-Nederland Gelderland Zuidwest-Gelderland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
GENERAL ELECTRIC DEUTSCHLAND HOLDING GMBH

Participation ended

Germany
Net EU contribution
€ 0,00
Address
Bleichstrasse 64-66
60313 Frankfurt Am Main

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Region
Darmstadt Frankfurt am Main, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
PHILIPS MEDICAL SYSTEMS NEDERLAND BV
Netherlands
Net EU contribution
€ 47 202,50
Address
Veenpluis 6
5684 PC Best

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Region
Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
SIEMENS HEALTHCARE LIMITED
United Kingdom
Net EU contribution
€ 0,00
Address
Faraday House Sir William Siemens Square
GU16 8QD Camberley

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Region
South East (England) Surrey, East and West Sussex West Surrey
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
AR BENELUX B.V.
Netherlands
Net EU contribution
€ 21 000,00
Address
Frankrijklaan 7
2391 PX Hazerswounde Dorp

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Region
West-Nederland Zuid-Holland Oost-Zuid-Holland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

BARTHEL HF-TECHNIK GMBH
Germany
Net EU contribution
€ 162 500,00
Address
Walkmuehlenstrasse 16
52074 Aachen

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Region
Nordrhein-Westfalen Köln Städteregion Aachen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
TESLA DYNAMIC COILS BV
Netherlands
Net EU contribution
€ 761 352,50
Address
Schimminck 12
5301KR Zaltbommel

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Oost-Nederland Gelderland Zuidwest-Gelderland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
GE HEALTHCARE GMBH - GEHC
Germany
Net EU contribution
€ 48 163,75
Address
Beethovenstrasse 239
42655 Solingen

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Region
Nordrhein-Westfalen Düsseldorf Solingen, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00