Objective
The NICI project’s ambition is to lay the foundations of a new area of research: the study of human biology using non-invasive chemistry imaging. For this, NICI aims to unite two areas of research: metabolomics and magnetic resonance imaging (MRI). Metabolomics studies body functions through the measurement of metabolites; MRI, is able to provide 3D images of the body. By advancing MRI so that it can detect metabolic biomarkers and by discovering powerful new MRI-visible biomarkers, a non-invasive technology can be developed for dynamically mapping biochemical processes in the whole human body.
Vision: This new non-invasive technology for imaging biochemical processes in the human body will open a new and effective window for understanding human biology, diseases and their treatment.
Breakthroughs: I. Methodology for the discovery of discriminative biomarkers and II. Technological platform for full body biochemical imaging.
Novelty: Enabling a paradigm shift from morphologic imaging to biochemical understanding.
Foundational: Establishing the basis for a new research area, the study of human biochemistry using non-invasive biochemical imaging.
High-risk: i) The exact mechanisms of diseases are largely unknown and ii) Measuring specific metabolites is challenging.
Interdisciplinary: Bringing together physicists, biologists, chemists and clinicians.
The NICI project will develop a new methodology for the in vitro discovery of discriminant biomarkers using co-cultured 3D organoids as models for human organs. In addition, the project will develop a measurement platform, integrated with 7T MRI scanners and associated data acquisition approaches to adapt these MRI scanners into 3D biochemical imaging systems. NICI will validate the dynamic 3D chemical imaging approach and its predictive and prognostic value by researching a stratification strategy for patients with liver metastasis of gastrointestinal cancer. (This is one out of many possible applications.)
Fields of science
- medical and health sciencesclinical medicineinternal medicine
- medical and health sciencesclinical medicineoncology
- medical and health sciencesclinical medicinepaediatrics
- medical and health sciencesclinical medicineorthopaedics
- engineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
3584 CX Utrecht
Netherlands
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Participants (13)
7491 Trondheim
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CB2 1TN Cambridge
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1105AZ Amsterdam
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56128 Calambrone Pisa
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
56126 Pisa
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Participation ended
5301 KR Zaltbommel
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Participation ended
60313 Frankfurt Am Main
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5684 PC Best
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GU16 8QD Camberley
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2391 PX Hazerswounde Dorp
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
52074 Aachen
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5301KR Zaltbommel
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
42655 Solingen
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