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Non-Invasive Chemistry Imaging in the whole human body

Objective

The NICI project’s ambition is to lay the foundations of a new area of research: the study of human biology using non-invasive chemistry imaging. For this, NICI aims to unite two areas of research: metabolomics and magnetic resonance imaging (MRI). Metabolomics studies body functions through the measurement of metabolites; MRI, is able to provide 3D images of the body. By advancing MRI so that it can detect metabolic biomarkers and by discovering powerful new MRI-visible biomarkers, a non-invasive technology can be developed for dynamically mapping biochemical processes in the whole human body.

Vision: This new non-invasive technology for imaging biochemical processes in the human body will open a new and effective window for understanding human biology, diseases and their treatment.

Breakthroughs: I. Methodology for the discovery of discriminative biomarkers and II. Technological platform for full body biochemical imaging.

Novelty: Enabling a paradigm shift from morphologic imaging to biochemical understanding.

Foundational: Establishing the basis for a new research area, the study of human biochemistry using non-invasive biochemical imaging.

High-risk: i) The exact mechanisms of diseases are largely unknown and ii) Measuring specific metabolites is challenging.

Interdisciplinary: Bringing together physicists, biologists, chemists and clinicians.

The NICI project will develop a new methodology for the in vitro discovery of discriminant biomarkers using co-cultured 3D organoids as models for human organs. In addition, the project will develop a measurement platform, integrated with 7T MRI scanners and associated data acquisition approaches to adapt these MRI scanners into 3D biochemical imaging systems. NICI will validate the dynamic 3D chemical imaging approach and its predictive and prognostic value by researching a stratification strategy for patients with liver metastasis of gastrointestinal cancer. (This is one out of many possible applications.)

Field of science

  • /medical and health sciences/clinical medicine/radiology/medical imaging/magnetic resonance imaging
  • /natural sciences/biological sciences/biochemistry
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

H2020-FETOPEN-1-2016-2017
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Address
Heidelberglaan 100
3584 CX Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 558 431,25

Participants (8)

NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Norway
EU contribution
€ 100 177,50
Address
Hogskoleringen 1
7491 Trondheim
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 610 307,50
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 598 593,75
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
IMAGO 7 FONDAZIONE DI RICERCA ONLUS
Italy
EU contribution
€ 608 343,75
Address
Viale Del Tirreno 331
56128 Calambrone Pisa
Activity type
Research Organisations
MR COILS BV

Participation ended

Netherlands
EU contribution
€ 497 066,25
Address
Shimminck 18
5301 KR Zaltbommel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GENERAL ELECTRIC DEUTSCHLAND HOLDING GMBH

Participation ended

Germany
EU contribution
€ 59 328,75
Address
Bleichstrasse 64-66
60313 Frankfurt Am Main
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PHILIPS MEDICAL SYSTEMS NEDERLAND BV
Netherlands
EU contribution
€ 58 370
Address
Veenpluis 6
5684 PC Best
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SIEMENS HEALTHCARE LIMITED
United Kingdom
EU contribution
€ 56 355
Address
Faraday House Sir William Siemens Square
GU16 8QD Camberley
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)