
Novel precision technological platforms to promote non-invasive early diagnosis, eradication and prevention of cancer relapse: proof of concept in the bladder carcinoma.
Objective
EDIT approach exploits the structural and mechanical properties of the bladder extracellular matrix (ECM) as a unique biomarker of the early onset/progression/relapse of carcinoma, through engineered novel gold nanorods (GNRs) used as intravesical photoacoustic antennas targeted at the ECM, generating an ad hoc visualization platform. GNRs will be further utilized as heat-releasing effectors at nanoscale for targeted cancer photo-thermal therapy. EDIT is designed to detect pre-neoplastic area and eradication of local areas at few cells resolution with high sensitivity and specificity.
We bring together a multi and transdisciplinary consortium capable to develop non-invasive and non-ionizing novel technology and preclinical validation for early prognosis of BCa and therapeutic nanomedicine against bladder Cis. Outcomes of EDIT will revolutionize the management of BCa with the introduction of sensing and effector nanotechnologies combined with non-invasive organ imaging with high resolution/definition by 3D ultrasound and photoacoustic imaging.
Structural and mechanical modification of the ECM is a common denominator for invasive breast, colorectal, prostate and bladder cancers. EDIT platforms will also pave the ways for the earlier management of other bladder-related pathologies and solid tumors.
Programme(s)
Funding Scheme
RIA - Research and Innovation action






Coordinator
OSPEDALE SAN RAFFAELE SRL
Address
Via Olgettina 60
20132 Milano
Italy
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU Contribution
€ 1 146 963,75
Participants (8)
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UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU Contribution
€ 480 125
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU Contribution
€ 374 350
FUJIFILM SONOSITE BV
Netherlands
EU Contribution
€ 681 625
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU Contribution
€ 350 225
LIME TECHNOLOGY IKE
Greece
EU Contribution
€ 298 570
ASCEND TECHNOLOGIES LIMITED
United Kingdom
EU Contribution
€ 400 500
OSM-DAN LTD
Israel
EU Contribution
€ 216 363,75
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU Contribution
€ 368 437,50
Project information
EDIT
Grant agreement ID: 801126
Status
Ongoing project
-
Start date
1 October 2018
-
End date
30 September 2022
Funded under:
H2020-EU.1.2.1.
-
Overall budget:
€ 4 317 160
-
EU contribution
€ 4 317 160
Project information
EDIT
Grant agreement ID: 801126
Status
Ongoing project
-
Start date
1 October 2018
-
End date
30 September 2022
Funded under:
H2020-EU.1.2.1.
-
Overall budget:
€ 4 317 160
-
EU contribution
€ 4 317 160
Deliverables
Deliverables not available
Publications
Project information
EDIT
Grant agreement ID: 801126
Status
Ongoing project
-
Start date
1 October 2018
-
End date
30 September 2022
Funded under:
H2020-EU.1.2.1.
-
Overall budget:
€ 4 317 160
-
EU contribution
€ 4 317 160
Project information
EDIT
Grant agreement ID: 801126
Status
Ongoing project
-
Start date
1 October 2018
-
End date
30 September 2022
Funded under:
H2020-EU.1.2.1.
-
Overall budget:
€ 4 317 160
-
EU contribution
€ 4 317 160