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Novel precision technological platforms to promote non-invasive early diagnosis, eradication and prevention of cancer relapse: proof of concept in the bladder carcinoma.

Objective

Unmet clinical needs in the management of bladder cancer (BCa) are the prevention of tumor onset, relapse and progression, and therapy of the aggressive carcinoma in situ (Cis), requiring weekly treatments and endless follow-up, with a consequent poor quality of life and the highest cost per patient among all cancers. Therefore, public health programs crave for early BCa detection protocols, to improve performance in the management of this devastating disease. Here we propose an advanced transformative technology termed EDIT combining a novel high-resolution ultrasound elastography and photoacoustic imaging on the bladder instilled with targeted plasmonic gold sensors.
EDIT approach exploits the structural and mechanical properties of the bladder extracellular matrix (ECM) as a unique biomarker of the early onset/progression/relapse of carcinoma, through engineered novel gold nanorods (GNRs) used as intravesical photoacoustic antennas targeted at the ECM, generating an ad hoc visualization platform. GNRs will be further utilized as heat-releasing effectors at nanoscale for targeted cancer photo-thermal therapy. EDIT is designed to detect pre-neoplastic area and eradication of local areas at few cells resolution with high sensitivity and specificity.
We bring together a multi and transdisciplinary consortium capable to develop non-invasive and non-ionizing novel technology and preclinical validation for early prognosis of BCa and therapeutic nanomedicine against bladder Cis. Outcomes of EDIT will revolutionize the management of BCa with the introduction of sensing and effector nanotechnologies combined with non-invasive organ imaging with high resolution/definition by 3D ultrasound and photoacoustic imaging.
Structural and mechanical modification of the ECM is a common denominator for invasive breast, colorectal, prostate and bladder cancers. EDIT platforms will also pave the ways for the earlier management of other bladder-related pathologies and solid tumors.

Call for proposal

H2020-FETOPEN-1-2016-2017
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Coordinator

OSPEDALE SAN RAFFAELE SRL
Address
Via Olgettina 60
20132 Milano
Italy
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 1 146 963,75

Participants (8)

UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 480 125
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 374 350
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
FUJIFILM SONOSITE BV
Netherlands
EU contribution
€ 681 625
Address
Joop Geesinkweg 140
1114 AB Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 350 225
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
LIME TECHNOLOGY IKE
Greece
EU contribution
€ 298 570
Address
Parodos Archiepiskopou Makariou 0
452 21 Ioannina
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASCEND TECHNOLOGIES LIMITED
United Kingdom
EU contribution
€ 400 500
Address
2 Venture Road, Southampton Science Park
SO16 7NP Southampton
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
OSM-DAN LTD
Israel
EU contribution
€ 216 363,75
Address
19 Pro Neeman Yuval St
7608665 Rehovot
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 368 437,50
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations