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Nanoparticles-based 2D thermal bioimaging technologies

Objective

Temperature measurements are crucial in countless technological developments, accounting for 80% of the sensor market throughout the world. The pitfalls of temperature readouts at the biomedical battleground are mostly represented by the currently achievable spatial resolution. To address key issues, such as intracellular temperature fluctuations and in vivo thermal transients, a technique able to go clearly below 1 μm is highly and urgently needed, as the traditional contact-based sensors and near infrared thermometers are not suitable for measurements at that tight spatial range. To overcome these limitations requires a non-contact thermometry approach granted with sub-micrometer resolution, also providing real-time high relative thermal sensitivity values.

The goal of NanoTBTech is to develop a 2-D thermal bioimaging technology featuring sub-microscale resolution, based on nanothermometers and heater-thermometer nanostructures. We will design, synthetize, and bio-functionalize nontoxic luminescent nanostructures, operating essentially beyond 1000 nm, for in vivo nanothermometry and nanoheating. Furthermore, to monitor the temperature-dependent nanostructures’ luminescence we will develop a novel imaging system. The effective delivery of that major advance in 2-D thermal bioimaging will be implemented through two impactful biomedical showcases: highly spatially-modulated intracellular magnetic/optical hyperthermia and in vivo detection and tracking of cancer.

In the long-term, we foresee our technology having a broad impact on non-invasive clinical imaging and theranostics. For instance, the accurate measurement of temperature gradients´ sources will be an invaluable tool for real-time control of thermal therapies, thus making them harmless for the patient. Multiple conceptual breakthroughs can be further envisaged from the proposed 2D-thermal imaging system, credibly spreading its impact towards non-biomedical technological areas.

Call for proposal

H2020-FETOPEN-2016-2017

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Sub call

H2020-FETOPEN-1-2016-2017

Coordinator

UNIVERSIDADE DE AVEIRO
Net EU contribution
€ 508 060,00
Address
Campus Universitário De Santiago
3810-193 Aveiro
Portugal

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Region
Continente Centro (PT) Região de Aveiro
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (10)

FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO RAMON Y CAJAL
Spain
Net EU contribution
€ 312 750,00
Address
Ctra Colmenar Vlejo Km 9.100
28034 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Other
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSIDAD AUTONOMA DE MADRID
Spain
Net EU contribution
€ 137 500,00
Address
Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 462 025,00
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

SORBONNE UNIVERSITE
France
Net EU contribution
€ 5 000,00
Address
21 Rue De L'ecole De Medecine
75006 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Net EU contribution
€ 354 432,50
Address
Calle Serrano 117
28006 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Non-EU contribution
€ 0,00
INSTITUT ZA NUKLEARNE NAUKE VINCA INSTITUT OD NACIONALNOG ZNACAJA ZA REPUBLIKU SRBIJU, UNIVERZITET U BEGRADU
Serbia
Net EU contribution
€ 258 750,00
Address
Mihajla Petrovica Alasa 12
11307 Vinca Beograd

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Region
Србија - север Београдски регион Београдска област
Activity type
Other
Non-EU contribution
€ 0,00
INSTYTUT NISKICH TEMPERATUR I BADAN STRUKTURALNYCH IM. WLODZIMIERZA TRZEBIATOWSKIEGO POLSKIEJ AKADEMII NAUK
Poland
Net EU contribution
€ 277 375,00
Non-EU contribution
€ 0,00
UNIVERSITEIT UTRECHT
Netherlands
Net EU contribution
€ 234 375,00
Address
Heidelberglaan 8
3584 CS Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
NANOIMMUNOTECH SL
Spain
Net EU contribution
€ 205 477,50
Address
Edificio Citexvi C Fonte Das Abelle Sn Campus Universitario De Vigo
36310 Vigo Pontevedra

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Galicia Pontevedra
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
BIOSPACE LAB
France
Net EU contribution
€ 243 737,50
Address
11 Rue De Chenival
95690 Nesles-la-vallee

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Val-d’Oise
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00