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Nanoparticles-based 2D thermal bioimaging technologies

Project information

Grant agreement ID: 801305

Status

Ongoing project

  • Start date

    1 September 2018

  • End date

    31 August 2021

Funded under:

H2020-EU.1.2.1.

  • Overall budget:

    € 2 999 482,50

  • EU contribution

    € 2 999 482,50

Coordinated by:

UNIVERSIDADE DE AVEIRO

Portugal

Objective

Temperature measurements are crucial in countless technological developments, accounting for 80% of the sensor market throughout the world. The pitfalls of temperature readouts at the biomedical battleground are mostly represented by the currently achievable spatial resolution. To address key issues, such as intracellular temperature fluctuations and in vivo thermal transients, a technique able to go clearly below 1 μm is highly and urgently needed, as the traditional contact-based sensors and near infrared thermometers are not suitable for measurements at that tight spatial range. To overcome these limitations requires a non-contact thermometry approach granted with sub-micrometer resolution, also providing real-time high relative thermal sensitivity values.

The goal of NanoTBTech is to develop a 2-D thermal bioimaging technology featuring sub-microscale resolution, based on nanothermometers and heater-thermometer nanostructures. We will design, synthetize, and bio-functionalize nontoxic luminescent nanostructures, operating essentially beyond 1000 nm, for in vivo nanothermometry and nanoheating. Furthermore, to monitor the temperature-dependent nanostructures’ luminescence we will develop a novel imaging system. The effective delivery of that major advance in 2-D thermal bioimaging will be implemented through two impactful biomedical showcases: highly spatially-modulated intracellular magnetic/optical hyperthermia and in vivo detection and tracking of cancer.

In the long-term, we foresee our technology having a broad impact on non-invasive clinical imaging and theranostics. For instance, the accurate measurement of temperature gradients´ sources will be an invaluable tool for real-time control of thermal therapies, thus making them harmless for the patient. Multiple conceptual breakthroughs can be further envisaged from the proposed 2D-thermal imaging system, credibly spreading its impact towards non-biomedical technological areas.

Coordinator

UNIVERSIDADE DE AVEIRO

Address

Campus UniversitÁRio De Santiago
3810-193 Aveiro

Portugal

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 508 060

Participants (8)

FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO RAMON Y CAJAL

Spain

EU Contribution

€ 450 250

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 467 025

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 354 432,50

INSTITUT ZA NUKLEARNE NAUKE VINCA

Serbia

EU Contribution

€ 258 750

INSTYTUT NISKICH TEMPERATUR I BADAN STRUKTURALNYCH IM. WLODZIMIERZA TRZEBIATOWSKIEGO POLSKIEJ AKADEMII NAUK

Poland

EU Contribution

€ 277 375

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 234 375

NANOIMMUNOTECH SL

Spain

EU Contribution

€ 205 477,50

BIOSPACE LAB

France

EU Contribution

€ 243 737,50

Project information

Grant agreement ID: 801305

Status

Ongoing project

  • Start date

    1 September 2018

  • End date

    31 August 2021

Funded under:

H2020-EU.1.2.1.

  • Overall budget:

    € 2 999 482,50

  • EU contribution

    € 2 999 482,50

Coordinated by:

UNIVERSIDADE DE AVEIRO

Portugal