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Extracellular vesicles from a natural source for tailor-made nanomaterials

Objective

Extracellular vesicles (EVs) are cell-derived, membranous particles that mediate intercellular communication by transferring biomolecules such as proteins and RNAs. The discovery of EVs as natural biocarriers and inter-species communication means has raised great interest in the drug delivery field. EVs intrinsically possess many attributes of a drug delivery vehicle, since these particles i) are well tolerated in the body, ii) have long circulating half-life, iii) are internalised by recipient cells and iv) are able of crossing the blood brain barrier. Native and drug-loaded mammalian cell-derived EVs have recently been developed and are contributing to the expanding research field known as “cell-free therapy”. Despite these promising progresses, translational applications are currently hampered by the lack of suitable processes for the isolation, characterisation and functionalisation of EVs. The aim of Ves4US is to develop a radically new platform for the efficient production and functionalisation of EVs, which will enable for their exploitation as tailor-made products in the fields of nanomedicine, cosmetics and nutraceutics. A core aspect of the project is to focus vesicles from an identified natural source, which could constitute a more economically viable and sustainable source of EVs. This will allow the development of natural nanocarriers with unprecedented abilities for drug delivery in specific tissues such as brain, lung, skin, dendritic or tumor cells. Ves4US is endorsed by prominent industrial stakeholders with strong interests in market-oriented innovation.
The actively emerging field of EV-based research and industrial/clinical translation will significantly profit from the proposed VES4US innovation of focusing on natural nanovesicles; the new knowledge created will influence the biomedical landscape of the future both within and outside the European Union.
The actively emerging field of EV-based research and industrial/clinical translation will significantly profit from the proposed VES4US innovation of focusing on natural source derived nanovesicles; the new knowledge created will influence the biomedical landscape of the future both within and outside the European Union.

Call for proposal

H2020-FETOPEN-1-2016-2017
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Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Address
Piazzale Aldo Moro 7
00185 Roma
Italy
Activity type
Research Organisations
EU contribution
€ 1 181 412,50

Participants (5)

INSTITUTE OF TECHNOLOGY SLIGO - ITS
Ireland
EU contribution
€ 560 187,50
Address
Ballinode - Ash Lane
F56 Sligo
Activity type
Higher or Secondary Education Establishments
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 499 998,75
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
UNIVERZA V LJUBLJANI
Slovenia
EU contribution
€ 193 750
Address
Kongresni Trg 12
1000 Ljubljana
Activity type
Higher or Secondary Education Establishments
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 303 455
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations
ZABALA INNOVATION CONSULTING, S.A.
Spain
EU contribution
€ 207 500
Address
Paseo Santxiki 3 Bis
31192 Mutilva Alta Navarra
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)