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Early Detection of cancer onset based on sensing field cancerization at the organ level

Objective

Cancer is a major cause of death worldwide. Gastrointestinal (GI) tract tumors are among the most common and deadliest
ones. Despite progress in imaging and treatment, the social impact of these diseases is enormous. All parties in the health
sector agree that prevention and/or early diagnosis is the most effective means to deal with cancer. Currently, cancer is
identified most often when symptomatic or large enough to be visualized in body scans or when histological alterations are
already present. What is lacking is an imaging method that could detect tissue changes that facilitate or predict tumor
development at an early stage. These alterations, collectively referred to as “field cancerization” is an exciting field of study
in cancer biology with profound ramifications in clinical practice. Molecular mechanisms underlying field cancerization are
being studied and the advances in molecular biology facilitate these studies. Never in the past however, have these changes
been sensed/measured by an imaging modality at the organ level. We thus propose the development of a multimodal
microscopy platform that will allow sensing of Raman and scattering properties at the organ level, in order to identify
molecular and structural fingerprints of early stage disease in the GI tract. Successful implementation will allow the
development of an endoscope especially designed for this purpose that will be used to detect early stage cancer in humans.

Call for proposal

H2020-FETOPEN-1-2016-2017
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Address
Soranou Efesiou 4
115 27 Athina
Greece
Activity type
Research Organisations
EU contribution
€ 541 812,50

Participants (6)

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 697 876,25
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
UNIVERSIDAD CARLOS III DE MADRID
Spain
EU contribution
€ 362 187,50
Address
Calle Madrid 126
28903 Getafe (Madrid)
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 438 781,25
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
RAYFOS LTD
United Kingdom
EU contribution
€ 231 918,75
Address
Winton House Winton Square
RG21 8EN Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MARIOS LYMARAKIS KAI SIA EE
Greece
EU contribution
€ 134 625
Address
Ethnikis Antistaseos 132
15344 Gerakas Attiki
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
RIVERD INTERNATIONAL BV
Netherlands
EU contribution
€ 558 125
Address
Marconistraat 16
3029 AK Rotterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)