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The Extracellular Vesicle Foundry

The Extracellular Vesicle Foundry

Objective

Extracellular vesicles (EVs) are natural cell-derived nanoparticles containing bioactive proteins and RNAs, which are newly recognized as the universal agents of intercellular and inter-organismal communication, in both normal and pathological processes.
EVs are reshaping our perspective on life sciences, environment and public health. They are under intensive investigation as early disease multi-biomarkers, while EV-based personalized therapeutic agents and vaccines have produced enticing results in early-phase clinical trials. However, EV exploitation is not supported by current manufacturing methods, which are inadequate in terms of purity and reproducibility or yield, time and cost.
evFOUNDRY targets a breakthrough technology able to streamline production of therapeutic EVs from sustainable sources, drawing the baseline for future EV bioprocessing, which is necessary for effective EV medical translation (large clinical trials and regulatory initiatives) and provides access to new EV applications (nanotechnology, nutraceuticals, cosmeceuticals, veterinary).
To meet the challenge, evFOUNDRY will unravel how EVs and EV fluids interact with surfaces and leverage it to develop the first device for continuous production of high-grade EVs from milk and parasites, which are the most promising scalable sources of EVs with immune modulatory properties.
Major objectives include: (i) to determine the compositional, structural and colloidal properties of EVs that control their interaction with surfaces; (ii) to engineer nanostructured surfaces integrated in microfluidic devices for separation of EV populations that are homogeneous in size and/or membrane properties from bovine milk and Ascaris incubation media; (iii) to design an integrated modular-system for the reproducible separation and analysis of these EVs under continuous flow; (iv) to implement a lab-scale prototype for the continuous production of quality-compliant immune modulatory EVs.
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Coordinator

CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE

Address

Via Della Lastruccia 3
50019 Firenze

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 639 375

Participants (5)

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LUNDS UNIVERSITET

Sweden

EU Contribution

€ 401 065

UNIVERSITY OF SOUTHAMPTON

United Kingdom

EU Contribution

€ 449 976,25

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 417 405

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 400 695

HANSABIOMED LIFE SCIENCES OU

Estonia

EU Contribution

€ 418 000

Project information

Grant agreement ID: 801367

Status

Ongoing project

  • Start date

    1 September 2018

  • End date

    31 August 2021

Funded under:

H2020-EU.1.2.1.

  • Overall budget:

    € 2 726 516,25

  • EU contribution

    € 2 726 516,25

Coordinated by:

CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE

Italy