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A multi-disciplinary international effort to identify clinical, molecular and social factors impacting cutaneous leishmaniasis

Objective

Leishmania causes devastating human diseases – leishmaniases - representing an important public health problem in the Mediterranean basin and declared as emerging diseases in the EU due to climate change and population displacement. The LeiSHield-MATI consortium will for the first time investigate in an integrative fashion the complex parasite-vector-host interplay in cutaneous leishmaniasis affecting Morrocco, Algeria, Tunisia, and Iran (MATI), using field isolates and human clinical samples. The ultimate goal of our project is to identify genetic factors selected during natural infection and to understand how the complex parasite-vector-animal interaction impacts clinical outcome in infected patients. This goal will be achieved through a highly ambitious secondment plan between all partners, and the organization of courses and workshops to train the next generation of scientists generating a long-term impact on the research capacities in endemic areas. Capitalizing on complementary infrastructures of its EU, African and Asian partners and their expertise in molecular parasitology, epidemiology, systems level analyses, bioinformatics, computational biology, immunology, dermatology, field studies, and public health, our project will drive important innovation in clinical research, strengthen capacities in disease endemic regions, inform authorities on control measures, and raise awareness in all partner countries on this emerging EU public health problem. The highly inter-disciplinary and inter-sectorial structure of LeiSHield-MATI, and its powerful integrative and comparative approach is novel in parasitic systems and will drive a unique bio-marker discovery pipeline for the future development of new prognostic and diagnostic tools, as well as novel preventive and therapeutic measures that will ensure long-term collaboration, promote scientific and commercial self-sustainability of its partners, and will have an important impact to improve public health.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /medical and health sciences/health sciences/parasitology
  • /medical and health sciences/basic medicine/immunology
  • /medical and health sciences/clinical medicine/dermatology
  • /medical and health sciences/health sciences/epidemiology

Call for proposal

H2020-MSCA-RISE-2017
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

INSTITUT PASTEUR
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
France
Activity type
Research Organisations
EU contribution
€ 526 500

Participants (5)

PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE
Belgium
EU contribution
€ 211 500
Address
Nationalestraat 155
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
ACOBIOM
France
EU contribution
€ 22 500
Address
1682 Rue De La Valsiere Cap Delta Zac Euromedecine Ii
34790 Grabels
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT PASTEUR DE TUNIS
Tunisia
EU contribution
€ 783 000
Address
Place Pasteur 13
1002 Tunis
Activity type
Research Organisations
UNIVERZITA KARLOVA
Czechia
EU contribution
€ 94 500
Address
Ovocny Trh 560/5
116 36 Praha 1
Activity type
Higher or Secondary Education Establishments
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 112 500
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments

Partners (3)

INSTITUT PASTEUR D'IRAN
Iran
Address
Pasteur Ave 69
1316943551 Tehran
Activity type
Research Organisations
Institut Pasteur Du Maroc
Morocco
Address
Place Louis Pasteur 1
20360 Casablanca
Activity type
Research Organisations
INSTITUT PASTEUR D ALGERIE E.P.I.C.
Algeria
Address
Route Du Petit Staoueli Dely Brahim
16000 Alger
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)