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A multi-disciplinary international effort to identify clinical, molecular and social factors impacting cutaneous leishmaniasis

Objective

Leishmania causes devastating human diseases – leishmaniases - representing an important public health problem in the Mediterranean basin and declared as emerging diseases in the EU due to climate change and population displacement. The LeiSHield-MATI consortium will for the first time investigate in an integrative fashion the complex parasite-vector-host interplay in cutaneous leishmaniasis affecting Morrocco, Algeria, Tunisia, and Iran (MATI), using field isolates and human clinical samples. The ultimate goal of our project is to identify genetic factors selected during natural infection and to understand how the complex parasite-vector-animal interaction impacts clinical outcome in infected patients. This goal will be achieved through a highly ambitious secondment plan between all partners, and the organization of courses and workshops to train the next generation of scientists generating a long-term impact on the research capacities in endemic areas. Capitalizing on complementary infrastructures of its EU, African and Asian partners and their expertise in molecular parasitology, epidemiology, systems level analyses, bioinformatics, computational biology, immunology, dermatology, field studies, and public health, our project will drive important innovation in clinical research, strengthen capacities in disease endemic regions, inform authorities on control measures, and raise awareness in all partner countries on this emerging EU public health problem. The highly inter-disciplinary and inter-sectorial structure of LeiSHield-MATI, and its powerful integrative and comparative approach is novel in parasitic systems and will drive a unique bio-marker discovery pipeline for the future development of new prognostic and diagnostic tools, as well as novel preventive and therapeutic measures that will ensure long-term collaboration, promote scientific and commercial self-sustainability of its partners, and will have an important impact to improve public health.

Coordinator

INSTITUT PASTEUR
Net EU contribution
€ 544 500,00
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (7)

PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE
Belgium
Net EU contribution
€ 63 000,00
Address
Nationalestraat 155
2000 Antwerpen

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Region
Vlaams Gewest Prov. Antwerpen Arr. Antwerpen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ACOBIOM
France
Net EU contribution
€ 13 500,00
Address
1682 Rue De La Valsiere Cap Delta Zac Euromedecine Ii
34790 Grabels

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Occitanie Languedoc-Roussillon Hérault
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
INSTITUT PASTEUR DE TUNIS
Tunisia
Net EU contribution
€ 756 000,00
Non-EU contribution
€ 0,00
UNIVERZITA KARLOVA
Czechia
Net EU contribution
€ 94 500,00
Address
Ovocny Trh 560/5
116 36 Praha 1

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Region
Praha Hlavní město Praha
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
GOETEBORGS UNIVERSITET
Sweden
Net EU contribution
€ 148 500,00
Address
Vasaparken
405 30 Goeteborg

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Region
Södra Sverige Västsverige Västra Götalands län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT
France
Net EU contribution
€ 121 500,00
Address
Boulevard De Dunkerque 44 Cs 90009
13572 Marseille

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Region
Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône
Activity type
Research Organisations
Non-EU contribution
€ 0,00
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
Net EU contribution
€ 9 000,00
Address
Rue Leblanc 25
75015 Paris 15

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Partners (3)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

INSTITUT PASTEUR D'IRAN
Iran
Net EU contribution
€ 0,00
Address
Pasteur Ave 69
1316943551 Tehran

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Research Organisations
Non-EU contribution
€ 504 000,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Institut Pasteur Du Maroc
Morocco
Net EU contribution
€ 0,00
Non-EU contribution
€ 288 000,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

INSTITUT PASTEUR D ALGERIE E.P.I.C.
Algeria
Net EU contribution
€ 0,00
Address
Route Du Petit Staoueli Dely Brahim
16000 Alger

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 436 500,00